Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis

Nampoothiri, Sreekala S.; Nogueiras, Rubén; Schwaninger, Markus; Prévot, Vincent

doi:10.1038/s42255-022-00610-z

Cited by 37 publications

(17 citation statements)

References 191 publications

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“…Second, it should be noted that Cre expression in Sim1 -Cre mouse is likely limited to neurons but not glial cells [ 44 , 51 ], while viral-mediated Rgs2 deletion in Rgs2 PVN-KO could have affected glial cells as we used AAV serotype 2 that expresses Cre-GFP under the CMV promoter [ 52 ]. Rgs2 seems to be expressed in glial cells such as astrocytes and microglia [ 53 ], and studies have shown that glial cells are also involved in the regulation of energy balance [ 54 , 55 ]. Thus, it is conceivable that in Rgs2 PVN-KO mice, Rgs2 was deleted not only in neurons but also in glia cells residing in the PVN; however, the impact of Rgs2 deletion in those PVN glia cells on energy balance remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice

Deng¹,

Dickey²,

Saito³

et al. 2022

Molecular Metabolism

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Section: Discussionmentioning

confidence: 99%

Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice

Deng¹,

Dickey²,

Saito³

et al. 2022

Molecular Metabolism

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“…In the context of systemic inflammation, the hypothalamus integrates signals from peripheral systems, translating them into neuroendocrine perturbations, altered neuronal signaling, and global metabolic derangements ( 295 ). Cancer is a homeostatic challenge to the organism ( 296 , 297 ), and, specifically, neural circuitry is disrupted in cancer ( 298 ).…”

Section: Implications For Prevention and Treatmentmentioning

confidence: 99%

The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment

Paul

Nedelcu

2022

Front. Oncol.

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In order to effectively manage and cure cancer we should move beyond the general view of cancer as a random process of genetic alterations leading to uncontrolled cell proliferation or simply a predictable evolutionary process involving selection for traits that increase cell fitness. In our view, cancer is a systemic disease that involves multiple interactions not only among cells within tumors or between tumors and surrounding tissues but also with the entire organism and its internal “milieu”. We define the internal body climate as an emergent property resulting from spatial and temporal interactions among internal components themselves and with the external environment. The body climate itself can either prevent, promote or support cancer initiation and progression (top-down effect; i.e., body climate-induced effects on cancer), as well as be perturbed by cancer (bottom-up effect; i.e., cancer-induced body climate changes) to further favor cancer progression and spread. This positive feedback loop can move the system towards a “cancerized” organism and ultimately results in its demise. In our view, cancer not only affects the entire system; it is a reflection of an imbalance of the entire system. This model provides an integrated framework to study all aspects of cancer as a systemic disease, and also highlights unexplored links that can be altered to both prevent body climate changes that favor cancer initiation, progression and dissemination as well as manipulate or restore the body internal climate to hinder the success of cancer inception, progression and metastasis or improve therapy outcomes. To do so, we need to (i) identify cancer-relevant factors that affect specific climate components, (ii) develop ‘body climate biomarkers’, (iii) define ‘body climate scores’, and (iv) develop strategies to prevent climate changes, stop or slow the changes, or even revert the changes (climate restoration).

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“…Among the CVOs, the median eminence (ME) and the area postrema (AP), located near the third and fourth ventricles, respectively, represent check-points for circulating signals acting on ARC and NTS neurons ( O'Rahilly and Farooqi, 2008a , 2008 b ), two key structures that regulate body weight dynamics. While being characterized by reduced fenestrated capillaries when compared with the ME, the ARC is enriched in tanycytes, a specialized glial cell type ( Garcia-Caceres et al., 2019 ; Nampoothiri et al., 2022 ; Prevot et al., 2018 ). Tanycytes control the fenestration of blood vessels at the ME/ARC junction and facilitate the transport of blood circulating signals onto energy sensing ARC neurons ( Balland et al., 2014 ; Langlet et al., 2013 ; Mullier et al., 2010 ; Rodriguez et al., 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis

Cited by 37 publications

References 191 publications

Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice

Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice

The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment

Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis

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