Glial-Derived Neurotrophic Factor Modulates Enteric Neuronal Survival and Proliferation Through Neuropeptide Y

Anitha, Mallappa; Chandrasekharan, Bindu; Salgado, Joana; Grouzmann, Eric; Mwangi, Simon M.; Sitaraman, Shanthi V.; Srinivasan, Shanthi

doi:10.1053/j.gastro.2006.07.019

Cited by 50 publications

(57 citation statements)

References 56 publications

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“…Moreover, NPY also stimulates the proliferation of neuronal progenitor cells (BrdU + /nestin + cells), which means that NPY promotes the proliferation of committed neural immature cells. Other studies also showed that NPY promotes proliferation of neuroblasts of olfactory epithelium, hippocampal precursor cells and rat enteric neurons (Hansel et al 2001;Howell et al 2003Howell et al , 2005Howell et al , 2007Anitha et al 2006). Using pharmacological tools, we also demonstrate that NPY increases cell proliferation through the activation of NPY Y 1 , Y 2 and Y 5 receptors.…”

Section: Discussionsupporting

confidence: 76%

“…The NPY receptor subtypes involved in the proliferative effect induced by NPY in other cell types is a matter of controversy. Most studies suggest that the NPY Y 1 receptor is mainly involved (Hansel et al 2001;Howell et al 2003Howell et al , 2005Howell et al , 2007Cho and Kim 2004;Milenkovic et al 2004;Anitha et al 2006). However, in vascular smooth muscle cells and endothelial cells some reports demonstrate that the mitogenic effect of NPY is mediated by Y 1 , Y 2 and Y 5 receptors (Zukowska-Grojec et al 1998;Lee et al 2003;Kitlinska et al 2005;Movafagh et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…These results suggest that the proproliferative effect of NPY on rat retinal cells is mediated through ERK 1/2 activation. This mechanism was shown to mediate the proliferative effect of NPY in rat hippocampal precursor cells, guinea pig Müller cells and rat enteric neurons (Milenkovic et al 2004;Howell et al 2005;Anitha et al 2006), as well as in chicken retinal progenitor cells and retinal pigmented epithelium cells (Cobb 1999;Hashimoto et al 2006;Spence et al 2007).…”

Section: Discussionmentioning

confidence: 99%

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Neuropeptide Y stimulates retinal neural cell proliferation – involvement of nitric oxide

Álvaro

Martins

Araújo

et al. 2008

Journal of Neurochemistry

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Neuropeptide Y (NPY) is a 36 amino acid peptide widely present in the CNS, including the retina. Previous studies have demonstrated that NPY promotes cell proliferation of rat post‐natal hippocampal and olfactory epithelium precursor cells. The aim of this work was to investigate the role of NPY on cell proliferation of rat retinal neural cells. For this purpose, primary retinal cell cultures expressing NPY, and NPY Y1, Y2, Y4 and Y5 receptors [Álvaro et al., (2007) Neurochem. Int., 50, 757] were used. NPY (10–1000 nM) stimulated cell proliferation through the activation of NPY Y1, Y2 and Y5 receptors. NPY also increased the number of proliferating neuronal progenitor cells (BrdU+/nestin+ cells). The intracellular mechanisms coupled to NPY receptors activation that mediate the increase in cell proliferation were also investigated. The stimulatory effect of NPY on cell proliferation was reduced by l‐nitroarginine‐methyl‐esther (l‐NAME; 500 μM), a nitric oxide synthase inhibitor, 1H‐[1,2,4]oxadiazolo‐[4, 3‐a]quinoxalin‐1‐one (ODQ; 20 μM), a soluble guanylyl cyclase inhibitor or U0126 (1 μM), an inhibitor of the extracellular signal‐regulated kinase 1/2 (ERK 1/2). In conclusion, NPY stimulates retinal neural cell proliferation, and this effect is mediated through nitric oxide–cyclic GMP and ERK 1/2 pathways.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neuropeptide Y stimulates retinal neural cell proliferation – involvement of nitric oxide

Álvaro

Martins

Araújo

et al. 2008

Journal of Neurochemistry

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“…GDNF has been shown to increase NPY expressing neurons. One of the possible mechanisms GDNF could influence β-cell mass could be through NPY 13 . Future studies will examine this possibility.…”

Section: Discussionmentioning

confidence: 99%

“…Apoptosis was assessed either by Western blotting for cleaved caspase-3 or cleaved caspase-3 with immunofluorescence microscopy 12,13 .…”

Section: Apoptosismentioning

confidence: 99%

Glial Cell Line-Derived Neurotrophic Factor Increases β-Cell Mass and Improves Glucose Tolerance

et al. 2008

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New anatomical profile of the nasal musculature: Dilator naris vestibularis, dilator naris anterior, and alar part of the nasalis

Youn

Song

et al. 2011

Clinical Anatomy

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The aim of this study was to clarify the morphology and topography of the dilator naris vestibularis, dilator naris anterior, and alar part of the nasalis. Anatomical variations in the topographic relationships are also described to provide critical data for understanding nasal muscular functions. Anatomical and histological examinations were performed on 40 specimens of embalmed Korean adult cadavers. The dilator naris vestibularis muscle (named by the present authors) was located between the external and vestibular skin of the alar lobule. The muscle fibers radiated along the dome-shaped nasal vestibule. The dilator naris anterior muscle originated from the frontal surfaces of the lateral half of the lateral crus and the accessory alar cartilage adjacent to the lateral crus. The extent of the lower insertion of the dilator naris anterior muscle was at the alar groove. The alar part of the nasalis originated with the transverse part of nasalis from the maxilla. It ascended to attach to the alar crease and the adjacent deep surface of external skin of the alar lobule. These findings may provide anatomical knowledge required to understand the structure and function of these nasal muscles such as during rhinoplasty or other surgery of the face.

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Glial-Derived Neurotrophic Factor Modulates Enteric Neuronal Survival and Proliferation Through Neuropeptide Y

Cited by 50 publications

References 56 publications

Neuropeptide Y stimulates retinal neural cell proliferation – involvement of nitric oxide

Neuropeptide Y stimulates retinal neural cell proliferation – involvement of nitric oxide

Glial Cell Line-Derived Neurotrophic Factor Increases β-Cell Mass and Improves Glucose Tolerance

New anatomical profile of the nasal musculature: Dilator naris vestibularis, dilator naris anterior, and alar part of the nasalis

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