Glimepiride prevents paraquat‐induced Parkinsonism in mice: involvement of oxidative stress and neuroinflammation

Ishola, Ismail O.; Akataobi, Onyinyechi E.; Alade, Azeez; Adeyemi, Olufunmilayo O.

doi:10.1111/fcp.12434

Cited by 20 publications

(17 citation statements)

References 43 publications

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“…Then, absorbance was read at 750 nm with UV-Vis spectrophotometer (UV-1800; Shimadzu Corporation, Kyoto, Japan). The standard curve was plotted using BSA (0.2-2.4 mg/mL) [31].…”

Section: Estimation Of Total Proteinmentioning

confidence: 99%

Novel potential of metformin on valproic acid‐induced autism spectrum disorder in rats: involvement of antioxidant defence system

Ishola

Balogun

Adeyemi

2020

Fundamemntal Clinical Pharma

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Prenatal exposure to valproic acid (VPA) has been shown to increase the risk of autism in children. This study examined the effect of metformin on VPA‐induced autism spectrum disorders in rats. Pregnant albino rats administered VPA (500 mg/kg, i.p.) or normal saline (10 mL/kg, i.p.; vehicle‐control) on gestational day 12.5. The pups were given metformin (5, 50 or 500 mg/kg, p.o.) or vehicle (10 mL/kg, p.o.) daily from postnatal day (PND) 21–50. Social behaviour, spatial learning/reference memory, repetitive behaviour and anxiety were assessed using the three‐chamber social assay, Morris water maze (MWM), Y maze and elevated plus maze tests (EPM), respectively. On PND 51, the animals were euthanized and brains removed for biochemical assay. In utero VPA exposure caused significant reduction in sociability index, social novelty preference index in three‐chambered apparatus and spatial learning and reference memory deficits in the MWM task as well as increase in repetitive/anxiety‐like behaviour in Y maze and EPM tests, respectively, which were ameliorated by post‐treatment with metformin in a dose‐dependent manner. Moreover, prenatal VPA increased malondialdehyde (MDA) and nitrite levels as well as deficits in antioxidant enzymes activities in the hippocampus and prefrontal cortex (PFC) which were attenuated by metformin administration. Similarly, VPA‐induced increase in acetylcholinesterase activity in the hippocampus and PFC were attenuated by postnatal treatment with metformin. Findings from this study showed that postnatal administration of metformin prevented valproic acid‐induced autistic‐like behaviour. Hence, metformin could be a potential adjunct in the management of autism spectrum disorders.

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“…Then, absorbance was read at 750 nm with UV-Vis spectrophotometer (UV-1800; Shimadzu Corporation, Kyoto, Japan). The standard curve was plotted using BSA (0.2-2.4 mg/mL) [31].…”

Section: Estimation Of Total Proteinmentioning

confidence: 99%

Novel potential of metformin on valproic acid‐induced autism spectrum disorder in rats: involvement of antioxidant defence system

Ishola

Balogun

Adeyemi

2020

Fundamemntal Clinical Pharma

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“…Ishola et al[ 21 ] administered glimepiride on a rodent model of paraquat-induced Parkinsonism with subsequent functional and molecular assessment of the treatment-induced changes. Sulfonylurea treatment attenuated oxidative stress and activation of inflammatory cascades in the neural tissue, while, simultaneously, improving the paraquat-induced memory dysfunction and cognitive performance on the rotarod, open field and Y-maze trials[ 21 ].…”

Section: Antidiabetic Treatment and Neural Functionmentioning

confidence: 99%

Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron

Xourgia

Papazafiropoulou

Μelidonis³

2019

WJD

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The detrimental effects of constant hyperglycemia on neural function have been quantitatively and qualitatively evaluated in the setting of diabetes mellitus. Some of the hallmark features of diabetic encephalopathy (DE) are impaired synaptic adaptation and diminished spatial learning capacity. Chronic and progressive cognitive dysfunction, perpetuated by several positive feedback mechanisms in diabetic subjects, facilitates the development of early-onset dementia and Alzheimer’s disease. Despite the numerous clinical manifestations of DE having been described in detail and their pathophysiological substrate having been elucidated in both type 1 and type 2 diabetes mellitus, an effective therapeutic approach is yet to be proposed. Therefore, the aim of this review is to summarize the growing body of evidence concerning the effect of current antidiabetic treatment options on diabetic and non-DE.

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“…A cutoff time of 5 min was applied. 51 Catalepsy was also measured by using a triple horizontal bars apparatus. It consisted of three metallic bars of diameter 2, 4, and 6 mm, respectively.…”

Section: Methodsmentioning

confidence: 99%

Parkinsonism Attenuation by Antihistamines via Downregulating the Oxidative Stress, Histamine, and Inflammation

et al. 2022

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Parkinson disease (PD) is a neurodegenerative disorder of the motor activity of the brain, regulated by dopaminergic neurons of substantia nigra, resulting in an increased density of histaminergic fibers. This study was aimed to evaluate the effects of H1 antagonist’s ebastine and levocetirizine in PD per se and in combination. Animals were divided into 9 groups ( n = 10). Group 1 received carboxymethyl cellulose CMC (1 mL/kg). Group II was treated with haloperidol (1 mg/kg) (diseased group). Group III was treated with levodopa/carbidopa (levo 20 mg/kg). Groups IV and V were treated with ebastine at dose levels of 2 and 4 mg/kg, respectively. Groups VI and VII were treated with levocetirizine at dose levels of 0.5 and 1 mg/kg, respectively. Group VIII was treated with ebastine (4 mg/kg) + levo (20 mg/kg) in combination. Group IX was treated with levocetirizine (1 mg/kg) + levo (20 mg/kg). PD was induced with haloperidol (1 mg/kg iv, once daily for 23 days) for a duration of 30 min. Behavioral tests like rotarod, block and triple horizontal bars, actophotometer, and open field were performed. Biochemical markers of oxidative stress, i.e., SOD, CAT, GSH, MDA, dopamine, serotonin, and nor-adrenaline and nitrite, were determined. Histamine, mRNA expression of α-synuclein, and TNF-α level in the serum and brain of mice were analyzed. Endogenous biochemical markers were increased except mRNA expression of α-synuclein, which was reduced. In combination therapy with the standard drug, ebastine (4 mg/kg) significantly improved the cataleptic state and dopamine levels, but no significant difference in the renal and liver functioning tests was observed. This study concluded that ebastine (4 mg/kg) might work in the treatment of PD as it improves the cataleptic state in haloperidol-induced catalepsy.

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Glimepiride prevents paraquat‐induced Parkinsonism in mice: involvement of oxidative stress and neuroinflammation

Cited by 20 publications

References 43 publications

Novel potential of metformin on valproic acid‐induced autism spectrum disorder in rats: involvement of antioxidant defence system

Novel potential of metformin on valproic acid‐induced autism spectrum disorder in rats: involvement of antioxidant defence system

Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron

Parkinsonism Attenuation by Antihistamines via Downregulating the Oxidative Stress, Histamine, and Inflammation

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