Glioblastoma, an opportunity T cell trafficking could bring for the treatment

Karimi‐Shahri, Mehdi; Khorramdel, Malihe; Zarei, Sadegh; Attarian, Fatemeh; Hashemian, Pedram; Javid, Hossein

doi:10.1007/s11033-022-07510-1

Cited by 6 publications

(5 citation statements)

References 98 publications

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“…Furthermore, TSA inhibits breast and prostate cancer growth by arresting the cell cycle and regulating apoptosis‐associated proteins 147,148 . Combination therapy with Herpesvirus and TSA on glioma and colorectal cancer has shown that these two agents have antitumor and antiangiogenesis activities by blocking VEGF and Cyclin D1 degradation 149–152 . Furthermore, this combination therapy for oral squamous cell carcinoma shows anticancer activity through increasing the cytoplasmic NF‐κB activity 149 .…”

Section: Virus In Combination Therapymentioning

confidence: 99%

“… 147 , 148 Combination therapy with Herpesvirus and TSA on glioma and colorectal cancer has shown that these two agents have antitumor and antiangiogenesis activities by blocking VEGF and Cyclin D1 degradation. 149 , 150 , 151 , 152 Furthermore, this combination therapy for oral squamous cell carcinoma shows anticancer activity through increasing the cytoplasmic NF‐κB activity. 149 DNA methyltransferase (DNMTs) gene encodes the enzymes and is important in epigenetic regulation.…”

Section: Virus In Combination Therapymentioning

confidence: 99%

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The role of viruses in cancer development versus cancer therapy: An oncological perspective

et al. 2023

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Despite great medical advances, oncological research is still looking for novel therapeutic approaches due to the limitation of conventional therapeutic agents. Virotherapy is one of these new emerging therapeutic approaches that attract attention with their widespread applications. Virotherapy use lives oncolytic viruses or genetically engineered viruses that selectively infect the tumor cells, replicate, and disrupt the cancerous cells that also induce their anticancer activity by stimulating the host antitumor immune response. Moreover, viruses are widely used as target delivery vectors for specifically delivering different genes, therapeutic agents, and immune‐stimulating agents. In addition to having antitumor activity by themselves in combination with conventional therapeutic agents like immune therapy and chemotherapy, Virotherapy agents also elicit promising outcomes. Therefore, in addition to their promising result in monotherapy use, virotherapy agents can also be used in combination with conventional cancer therapy, epigenetic modulators, and even microRNAs without any cross‐resistance, which allows the patient not to be deprived of her routine medicine. Still, this combination therapy reduces the adverse effect of the conventional therapies. All together suggest that virotherapy agents as novel potential agents in the field of cancer therapy.

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Section: Virus In Combination Therapymentioning

confidence: 99%

Section: Virus In Combination Therapymentioning

confidence: 99%

The role of viruses in cancer development versus cancer therapy: An oncological perspective

et al. 2023

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“…Therefore, a better understanding of PCSK9's role in the cancerous pathways is extremely important ( 7 ). Since this marker has a significant role in different parts of body, it has been used as a pharmacological target in the past few years ( 8 - 10 ).…”

Section: Introductionmentioning

confidence: 99%

Current Understanding of PCSK9 and Its Relevance to Cancer Prognosis and Immune Therapy: A Review

Hassandokht Mashhadi,

Taheri,

Irani

et al. 2024

Iran J Pathol

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“…In the current phase of development for BC, most cancer immunotherapies modulate immune regulation (assuming an endogenous antitumor immune response is present), direct immune responses toward tumor antigens (TAs), or combine these two approaches 10 . Antibodies designed to activate immune cells while suppressing immune cells can modulate pre‐existing cancer immunity 11,12 . In contrast, cancer vaccines target abnormally expressed cancer antigens to induce an immune response.…”

Section: Introductionmentioning

confidence: 99%

“…10 Antibodies designed to activate immune cells while suppressing immune cells can modulate preexisting cancer immunity. 11,12 In contrast, cancer vaccines target abnormally expressed cancer antigens to induce an immune response. There have been promising results with both immune checkpoint antibodies and cancer vaccines in BC research, and registration trials are currently underway.…”

mentioning

confidence: 99%

The therapeutic potential of immunotherapy in the treatment of breast cancer: Rational strategies and recent progress

Javid

Attarian

Saadatmand

et al. 2023

J of Cellular Biochemistry

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The second leading cause of cancer death in women worldwide is breast cancer (BC), and despite significant advances in BC therapies, a significant proportion of patients develop metastasis and disease recurrence. Currently used treatments, like radiotherapy, chemotherapy, and hormone replacement therapy, result in poor responses and high recurrence rates. Alternative therapies are therefore needed for this type of cancer. Cancer patients may benefit from immunotherapy, a novel treatment strategy in cancer treatment. Even though immunotherapy has been successful in many cases, some patients do not respond to the treatment or those who do respond relapse or progress. The purpose of this review is to discuss several different immunotherapy approaches approved for the treatment of BC, as well as different strategies for immunotherapy for the treatment of BC.

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Glioblastoma, an opportunity T cell trafficking could bring for the treatment

Cited by 6 publications

References 98 publications

The role of viruses in cancer development versus cancer therapy: An oncological perspective

The role of viruses in cancer development versus cancer therapy: An oncological perspective

Current Understanding of PCSK9 and Its Relevance to Cancer Prognosis and Immune Therapy: A Review

The therapeutic potential of immunotherapy in the treatment of breast cancer: Rational strategies and recent progress

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