Glioblastoma multiforme (GBM) of the conus medullaris with brain and brain stem metastases

Elsamaloty, Haitham; Zenooz, Navid A.; Mossa‐Basha, Mahmud

doi:10.1016/j.ejrex.2006.02.008

Cited by 9 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When intramedullary low-grade astrocytomas metastasize intracranially, most of them have malignant transformation 6,19) . In most of the cases reported up until now, spinal cord tumors that spread intracranially had previous malignant transformation or were high-grade gliomas 7,21,24,25) , even though in children, some cases without malignant transformation have been reported 1,2,5,9,11,17) . In 1995, Claus et al 6) reported the case of a 43-year-old man with intracranial dissemination of a WHO Grade I pilocytic astrocytoma of the cauda equina.…”

Section: Discussionmentioning

confidence: 99%

“…Spinal cord tumors account for 2-5% of central nervous systems neoplasms in adults 1,7,20) . Intramedullary spinal cord astrocytomas represent only 6-8% of spinal cord tumors 4,15,16) .…”

Section: Discussionmentioning

confidence: 99%

“…Cerebral metastases of a primary spinal astrocytoma have rarely been reported 1,6,13,17,19,22,24,25) . Of the spinal cord gliomas reported to have metastasized to the brain, most were anaplastic astrocytomas or glioblastoma multiforme 7,13,19,20,24,25) . Seeding to cranial sites from intramedullary low-grade astrocytoma has been reported in only a few cases; these have reported intracranial spread of intramedullary pilocytic astrocytoma without malignant transformation in a child 1,17) and with malignant transformation in an adult 6,19,24) .…”

Section: Introductionmentioning

confidence: 99%

“…Spinal cord astrocytomas are uncommon, accounting for less than 1% of all primary neoplasms in the central nervous system 4,7,8,10,20) . Cerebral metastases of a primary spinal astrocytoma have rarely been reported 1,6,13,17,19,22,24,25) .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult

Jang

Kong

Song

et al. 2009

J Korean Neurosurg Soc

View full text Add to dashboard Cite

The first case of intracranial metastases of a cervical intramedullary low-grade astrocytoma without malignant transformation in adult is presented in this report. Seven years ago, a 45 year-old male patient underwent biopsy to confirm pathologic characteristics and received craniocervical radiation and chemotherapy for a grade II astrocytoma in the cervical spinal cord. Two years later, posterior fusion was necessary for progressive kyphosis in the cervical spine. He was well for approximately 7 years after the primary surgery. Two months ago, he presented with partial weakness and incoordination with gait difficulty. MRI Scan demonstrated multiple small lesions in the cerebellar vermis and left hemisphere. After suboccipital craniectomy and posterior cervical exposure, the small masses in the cerebellar vermis and hemispheres were excised to a large extent by guidance of an intraoperative navigation system. The tumor at the cervical and brain lesions was classified as an astrocytoma (WHO grade II). When a patient with low-grade astrocytoma in the spinal cord has new cranial symptoms after surgery, radiaton, and chemotherapy, the possibility of its metastasis should be suspected because it can spread to the intracranial cavity even without malignant transformation as shown in this case.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Spinal cord tumors account for 2-5% of central nervous systems neoplasms in adults 1,7,20) . Intramedullary spinal cord astrocytomas represent only 6-8% of spinal cord tumors 4,15,16) .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult

Jang

Kong

Song

et al. 2009

J Korean Neurosurg Soc

View full text Add to dashboard Cite

show abstract

“…Distant metastasis arising from spinal cord glioblastomas has already been reported [7,[21][22][23][24][25][26][27], with a poor prognosis of around six months [27]. Taking best known practice in cerebral glioblastoma as a guide, the optimum treatment would seem to be complete macroscopic surgical resection followed by a combination of radiotherapy and chemotherapy [28].…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma of the Conus Medullaris Following Treatment of Hodgkin's Lymphoma: History of a Case and Literature Review

Pichon¹,

Champiat²,

Aumont³

et al. 2017

OMICS J Radiol

View full text Add to dashboard Cite

Purpose: Reports of a glioblastoma arising in a previously irradiated field are rare in the literature, even more so in the conus medullaris of the spinal cord. Method:Case report and review of the literature reporting other radiation-induced intra-medullary glioblastomas. Results:We report a case of glioblastoma of the conus, which subsequently metastasized to the brain, arising in a 45 years old man, nine years after treatment for Hodgkin's lymphoma, which had included the administration of 41 Gy to the brain and spinal cord. Conclusion:Despite a well-conducted treatment by several lines of chemotherapy, the pronostic of radiationinduced glioblastoma is poor especially since these patients often cannot benefit from a re-irradiation due to the maximum dose supported by the spinal cord. Implications of cancer survivors:Associations are now established between therapeutic exposures and specific complications but considerable inter-individual variability is observed for a given therapeutic exposure. In this context, identification of genetic susceptibilities for specific treatment-associated late effect is a very promising future approach. Improvement in our knowledge on genetic susceptibilities may help define more personalized primary therapies that weigh treatment efficacy with the risk of late complications.

show abstract

Predictive Factors Determining the Overall Outcome of Primary Spinal Glioblastoma Multiforme: An Integrative Survival Analysis

et al. 2016

View full text Add to dashboard Cite

Glioblastoma multiforme (GBM) of the conus medullaris with brain and brain stem metastases

Cited by 9 publications

References 7 publications

Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult

Intracranial Metastases of Cervical Intramedullary Low-Grade Astrocytoma without Malignant Transformation in Adult

Glioblastoma of the Conus Medullaris Following Treatment of Hodgkin's Lymphoma: History of a Case and Literature Review

Predictive Factors Determining the Overall Outcome of Primary Spinal Glioblastoma Multiforme: An Integrative Survival Analysis

Contact Info

Product

Resources

About