Glioblastoma multiforme of the conus medullaris with holocordal spread

Bonde, Vivek; Balasubramaniam, Srikant; Goel, Atul

doi:10.1016/j.jocn.2006.12.015

Cited by 25 publications

(15 citation statements)

References 8 publications

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“…To the best of our knowledge, only 16 cases of spinal GBM involving the conus medullaris have been previously reported (1,4,13–19,20–24), making this case the first with spinal and intracranial metastasis with hydrocephalus and the third most longest survival (21 months).…”

Section: Discussionmentioning

confidence: 91%

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Primary spinal glioblastoma: A case report and review of the literature

et al. 2012

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Primary spinal glioblastoma (GBM) is a rare disease, with an aggressive course and a poor prognosis. We report a case of a 19-year-old male with a 4-week history of progressive weakness in both lower limbs, which progressed to paraparesis with a left predominance and difficulty in initiating urination over a week. Spine magnetic resonance imaging (MRI) showed an intramedullary expansile mass localised between T6 and T11. We performed a laminotomy and laminoplasty between T6 and T11 and the tumour was partially removed. Histopathological study was compatible with GBM. The patient was administered focal spine radiotherapy with chemotherapy with temozolamide. Serial MRI performed after the initial surgery demonstrated enlargement of the enhancing mass from T3 to T12 and subarachnoid metastatic deposits in C2 and C4, the pituitary stalk, inter-peduncular cistern, left superior cerebellar peduncle and hydrocephalus. We review the literature with regard to the disease and treatment options, and report the unique features of this case. Primary spinal GBM is an extremely rare entity with a poor prognosis and a short survival time. An aggressive management of the different complications as they arise and improvement of current modes of treatment and new treatment options are required to improve survival and ensure better quality of life.

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Section: Discussionmentioning

confidence: 91%

“…MRI is considered the gold standard imaging modality to diagnose intramedullary tumours (13,14), and gadolinium-enhanced MRI of the entire neuroaxis is advocated to rule out metastasis, evaluate treatment efficacy and detect relapse (15). …”

Section: Discussionmentioning

confidence: 99%

Primary spinal glioblastoma: A case report and review of the literature

et al. 2012

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“…4 In this case, cervical MRI showed diffuse swelling of the spinal cord in a T1-weighted image, intramedullary high signal for which the margin was obscure in a T2-weighted image, and heterogeneously nodular and diffuse enhancement at the right side at the levels C1 to 4 with contrast administration. These findings were almost compatible with the literature.…”

Section: Discussionmentioning

confidence: 62%

Cervical Intramedullary Glioblastoma With Intracranial Dissemination: Description of a Rapidly Progressing Case and a Literature Review

Ando

Matsuyama

Sakai

et al. 2010

J. Musculoskelet. Res.

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We present a case of a 65-year-old female with glioblastoma of the spinal cord, which disseminated to an intracranial lesion. Magnetic resonance imaging revealed diffuse swelling at levels C1 to 4, which was pathologically consistent with glioblastoma, and right side pontine parenchyma mass. The patient died after seven weeks of hospitalization. The confirmed diagnosis of glioblastomas was obtained as a result of autopsy. Spinal glioblastomas are rare lesions of the central nervous system with a prognosis as poor as that of their intracranial counterpart. There have been only nine reports in English since 1990, including this case in Japan.

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“…[12,13] The majority of primary spinal GBM lesions appear as infiltrative, expansile masses with high T2 signal, and heterogeneous enhancement on postcontrast T1-weighted sequences. [14–16] However, differentiation of primary spinal GBM from other spinal diseases, such as transverse myelitis or other intramedullary tumors, is difficult, since primary spinal GBM tumors sometimes show ambiguous MRI characteristics.…”

Section: Discussionmentioning

confidence: 99%

Primary spinal glioblastoma multiforme

Shen

Zhao

et al. 2017

Medicine

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Rationale:Primary spinal glioblastoma multiforme (GBM) is a rare clinical entity with an aggressive course and an invariably dismal prognosis. Its clinical characteristics, radiologic and pathologic findings, and treatment protocols have been discussed in a few cases.Patient concerns:A 15-year-old female was admitted to the neurology department with a chief complaint of progressive numbness and weakness in her left upper extremity for 3 months and neck pain for 1 month.Diagnoses:Spinal magnetic resonance imaging showed an intramedullary expansile mass localized between C4 and C7. The diagnosis of GBM was determined on the basis of the histopathological findings after operation.Interventions:Laminotomy and laminoplasty between C4 and C7 were performed, and the tumor was partially resected. The patient was administered focal adjuvant radiotherapy concomitantly with oral chemotherapy following the surgery.Outcomes:With severe neurologic deficits at 13 months after the diagnosis, the patient expired.Lessons:Although therapeutic options have been improving, the prognosis of the primary spinal GBM remains poor. The treatment of primary spinal GBM entered into a central registry and multiple-center cooperation is important in establishing future therapeutic strategies.

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Glioblastoma multiforme of the conus medullaris with holocordal spread

Cited by 25 publications

References 8 publications

Primary spinal glioblastoma: A case report and review of the literature

Primary spinal glioblastoma: A case report and review of the literature

Cervical Intramedullary Glioblastoma With Intracranial Dissemination: Description of a Rapidly Progressing Case and a Literature Review

Primary spinal glioblastoma multiforme

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