Glioblastoma multiforme with oculomotor nerve involvement: case report and literature review

Marchesini, Nicolò; Bernasconi, Riccardo; Ghimenton, Claudio; Pinna, Giampietro

doi:10.1080/02688697.2020.1837732

Cited by 4 publications

(7 citation statements)

References 17 publications

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“…Reported cases of gliomas with direct involvement of a cranial nerve, from the third to the twelfth, were very rare [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] ( Table 1 ); among them the glioblastoma (WHO grade IV) was the most common (11 cases [ 10 , 11 , 14 , [22] , [23] , [24] ]), followed by the low-grade gliomas; no cases of gliosarcoma were described. The anatomical region and the cranial nerves more often affected were the cerebellopontine angle and trigeminal and vestibulocochlear nerves, while the oculomotor nerve was involved only 2 times.…”

Section: Discussionmentioning

confidence: 99%

“…The anatomical region and the cranial nerves more often affected were the cerebellopontine angle and trigeminal and vestibulocochlear nerves, while the oculomotor nerve was involved only 2 times. In most of the cases clinical symptoms related to the cranial nerve directly involved were present; only 5 cases of high-grade temporal glioma associated to isolated third cranial nerve palsy were reported in the literature [ 11 , [25] , [26] , [27] , [28] ]. We first report a case of temporo-mesial gliosarcoma, with exophytic pattern of growth to the ambient and crural cisterns and with sleeve involvement of the ipsilateral third cranial nerve, with encasement of the anterior choroidal, posterior communicant and posterior cerebral arteries, presenting without symptoms of peripheral neuropathy.…”

Section: Discussionmentioning

confidence: 99%

“…2018 [24] 55, m GBM – IV CPA VIII R Y Marchesini et al. 2020 [11] 69, M GBM - IV Frontal/ Temporal III L Y Present case 61, F Gliosarcoma - IV Temporal III R N WHO, World Health Organization; CN, Cranial nerve; F, Female; M, Male; n.a., not available; CPA, Cerebellopontine Angle; TREZ, Trigeminal Root Entry Zone; r, right; l, left; Y, Yes; N, Not. …”

Section: Discussionmentioning

confidence: 99%

“…It more frequently affects the cerebral hemispheres, with a predilection for the temporal lobes [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , followed by the rarer localizations at the posterior cranial fossa and spinal cord. The direct involvement of a cranial nerve by gliomas is very rare [ 10 , 11 ], and no cases of gliosarcoma are described. We first report a case of temporo-mesial gliosarcoma, with extension to the crural and ambient cisterns, with direct involvement of the ipsilateral third cranial nerve and encasement of the anterior choroidal, posterior communicant and posterior cerebral arteries, presenting without symptoms of peripheral neuropathy.…”

Section: Introductionmentioning

confidence: 99%

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Gliosarcoma with direct involvement of the oculomotor nerve: Case report and literature review

Corvino¹,

Peca²,

Corazzelli³

et al. 2022

Radiology Case Reports

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Gliosarcoma is a rare malignant brain tumor, characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation. We first report a case of temporo-mesial gliosarcoma, extended to the crural and ambient cisterns, with direct involvement of the ipsilateral third cranial nerve and encasement of anterior choroidal, posterior communicant and posterior cerebral arteries, presenting without symptoms of peripheral neuropathy. A 61-year-old woman with 1-month history of intense bilateral frontal-temporal headache resistant to pharmacological therapy and paresis of the left lower midface underwent surgical resection, through pterional trans-sylvian approach, of a right temporo-mesial gliosarcoma which directly involved the ipsilateral oculomotor nerve. Reported cases of gliomas with direct involvement of a cranial nerve, from the third to the twelfth, are very rare, whit no cases of gliosarcoma described. Because of its rarity, sometimes this entity is not considered as diagnostic hypothesis and is misdiagnosed, both during preoperative diagnostic evaluation and during the surgery. Gliosarcoma is a strong challenge for neurosurgeons and neurooncologists because of low incidence, poor prognosis and limited reported cases on literature. This case shows unique features for localization, pattern of growth and clinical presentation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gliosarcoma with direct involvement of the oculomotor nerve: Case report and literature review

Corvino¹,

Peca²,

Corazzelli³

et al. 2022

Radiology Case Reports

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“…Reifenberger and more recently Marchesini described GBM arising from oculomotor cranial nerve [7,8].…”

Section: Discussionmentioning

confidence: 99%

Primary Glioblastoma of Trigeminal Root Entry Zone and Internal Auditory Canal: Case Report

Jalil¹,

ThiNgocPhuong²,

Emmanuel³

et al. 2022

Neurosurg Cases Rev

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Background: Glioblastoma developed from cranial nerves are extremely rare. We report the case of a 71-year-old woman with glioblastoma arising from both trigeminal root entry zones and Internal Auditory Canal (IAC) nerves. Observations:The patient presented with facial numbness and paresthesia in both trigeminal sensory territories with initial Magnetic Resonance Imaging (MRI) at 1-month follow up showing contrast enhancement and thickening of both trigeminal nerves root entry zone and moderate thickening of IAC bundle, suggesting inflammatory disease. Cranial nerves deficit and neuroimaging were rapidly evolving within few months, with appearance of multiples necrotic lesions of pons, midbrain and left cerebellar hemisphere.Histopathological examination on cerebellar biopsy revealed glioblastoma. The patient underwent no further treatment and died one week after biopsy. Lessons:To the author's knowledge, this is the first case of primary glioblastoma arising simultaneously from multiple cranial nerves.

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A rare case of atypical intradural extramedullary glioblastoma diagnosed utilizing next-generation sequencing and methylation profiling: illustrative case

Shelton,

Mathews,

Aljiboori

et al. 2024

Journal of Neurosurgery: Case Lessons

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BACKGROUND Primary spinal cord tumors, especially primary spinal cord glioblastoma multiforme (PSC-GBM), are exceptionally rare, accounting for less than 1.5% of all spinal tumors. Their infrequency and aggressive yet atypical presentation make diagnosis challenging. In uncertain cases, a surgical approach for tissue diagnosis is often optimal. OBSERVATIONS A 76-year-old male presented with a rapidly progressing clinical history marked by worsening extremity weakness, urinary retention, and periodic fecal incontinence alongside diffuse changes on neuraxis imaging. The patient, in whom subacute polyneuropathy was initially diagnosed, received multiple rounds of steroids and intravenous immunoglobulin without clinical improvement. Histopathological review of the biopsy tissue yielded an initial diagnosis of spindle cell neoplasm. Next-generation sequencing (NGS) is done routinely on all neuropathology specimens at the authors’ institution, and methylation profiling is pursued in difficult cases. Ultimately, NGS and methylation profiling results were essential to an integrated final diagnosis of GBM. LESSONS PSC-GBM is a rare but highly aggressive occurrence of this tumor. Prolonged back pain, rapid neurological decline, and imaging changes warrant the consideration of lesional biopsy for precise disease characterization. In inconclusive cases, NGS has proved invaluable for clinical clarification and diagnosis, underscoring its importance for integrated diagnoses in guiding appropriate treatment strategies.

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Glioblastoma multiforme with oculomotor nerve involvement: case report and literature review

Cited by 4 publications

References 17 publications

Gliosarcoma with direct involvement of the oculomotor nerve: Case report and literature review

Gliosarcoma with direct involvement of the oculomotor nerve: Case report and literature review

Primary Glioblastoma of Trigeminal Root Entry Zone and Internal Auditory Canal: Case Report

A rare case of atypical intradural extramedullary glioblastoma diagnosed utilizing next-generation sequencing and methylation profiling: illustrative case

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