Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC

Quezada, Claudia; Peigñan, Lilia; Segura, Rodrigo; Riquelme, F.; Melo, Rómulo; Z, David Rojas; Ayach, Freddy; Martin, R. H.; Cárcamo, Juan G.

doi:10.4067/s0034-98872011000400001

Cited by 20 publications

(2 citation statements)

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“…Los antecedentes demográficos y clínicos de nuestra muestra no difirieron de lo publicado en series internacionales y de datos nacionales previamente disponibles 25 . Sin embargo, solo una minoría de los pacientes recibió quimioterapia alquilante, actualmente considerada parte del tratamiento estándar 4,6 .…”

Section: Discussionunclassified

Expresión de O6-metilguanina-ADN-metiltransferasa (MGMT) en pacientes chilenos con glioblastoma multiforme

et al. 2018

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Section: Discussionunclassified

Expresión de O6-metilguanina-ADN-metiltransferasa (MGMT) en pacientes chilenos con glioblastoma multiforme

et al. 2018

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“…Up to now, the mechanism underlying S1P export by GSCs is unknown. It should be noted that different ABCTs, known as transporters of S1P through the cell plasma membrane, and particularly ABCB1, ABCC1, and ABCG2, are highly expressed in GBM cells, and particularly in GSCs [127][128][129]. Their expression is correlated with GBM aggressiveness [130], suggesting their possible involvement in the S1P export from GSCs/GBM cells.…”

Section: S1p Secretion By Gbm Cells and Gscsmentioning

confidence: 99%

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks

Riboni

Hadi

Navone

et al. 2020

Cells

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As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on glioblastoma, representative of a highly aggressive and deleterious neoplasm in humans. First, we highlight recent advances and emerging concepts for how tumor cells and different recruited normal cells contribute to the sphingosine-1-phosphate enrichment in the cancer microenvironment. Then, we describe and discuss how sphingosine-1-phosphate signaling contributes to favor cancer hallmarks including enhancement of proliferation, stemness, invasion, death resistance, angiogenesis, immune evasion and, possibly, aberrant metabolism. We also discuss the potential of how sphingosine-1-phosphate control mechanisms are coordinated across distinct cancer microenvironments. Further progress in understanding the role of S1P signaling in cancer will depend crucially on increasing knowledge of its participation in the tumor microenvironment.

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Emphasizing unique strengths and eliminating redundancy for research in low‐income and middle‐income countries: Lessons from a South American country

Burotto

Prasad

2015

Cancer

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Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC

Abstract: Study of resistance to chemotherapy mediated by abc transporters in biopsies of glioblastoma multiforme (Rev Med Chile 2011; 139: 415-424).

Cited by 20 publications

References 28 publications

Expresión de O6-metilguanina-ADN-metiltransferasa (MGMT) en pacientes chilenos con glioblastoma multiforme

Expresión de O6-metilguanina-ADN-metiltransferasa (MGMT) en pacientes chilenos con glioblastoma multiforme

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks

Emphasizing unique strengths and eliminating redundancy for research in low‐income and middle‐income countries: Lessons from a South American country

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