Glioblastoma Secondary to Meningioma: A Case Report and Literature Review

Sahuc, P.; Joubert, Christophe; Nguyen, Anh-Tuan; Fouet, Bernard; Wybrecht, D.; Faivre, Anthony; Alla, P.; Dagain, Arnaud

doi:10.1016/j.wneu.2016.11.025

Cited by 7 publications

(5 citation statements)

References 26 publications

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“…In several case reports, GBMs have previously been reported to be present along with meningioma, but no reports were found identifying GBM co-existing with a dermoid cyst. In one case report by Sahuc et al, a patient had a meningioma treated with complete resection who suffered two subsequent recurrences, which ultimately were histopathologically confirmed to be GBM [ 9 ]. Suzuki et al reported a similar case of simultaneous formation of GBM with meningioma.…”

Section: Discussionmentioning

confidence: 99%

Long-term Seizure Disorder Caused by a Dermoid Cyst with Catastrophic Developments

Alam

Mugge

Purdy

et al. 2018

Cureus

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Glioblastoma multiforme (GBM) is a World Health Organization (WHO) grade IV primary malignant astrocytoma. Aneurysms are devastating intracranial neurovascular pathologies. Intracranial dermoid cysts are common, benign lesions which can be clinically silent or associated with seizure disorder.We describe physically adjacent diagnoses of dermoid cyst, intracranial aneurysm, and GBM in a single patient. Records were collected and reviewed to compile the final clinical picture.A 72-year-old male with a long history of seizure disorder, presented with new focal, unilateral neurological deficits. Radiographic evaluation including computed tomography (CT) and magnetic resonance imaging (MRI) demonstrated a dermoid cyst with an underlying developing GBM, which also, by happenstance, contained an aneurysm. During open surgical resection, multiple macroscopically distinct tissue types were noted. Histological analysis of tissue from each lesion confirmed the diagnoses including dermoid cyst, GBM, and aneurysm. Pathological analysis revealed the presence of extensive inflammatory cells throughout. Subsequent staining identified CD68 positive cells indicating a probable chronic inflammatory state.Chronic inflammation resulting from the presence of a long term dermoid cyst and ongoing seizures may have led to dystrophic changes in adjacent vasculature and approximating glial tissues, inducing the formation of an aneurysm and a secondary GBM. Therefore, while benign in nature, dermoid cysts can be related to seizure disorder and may cause chronic inflammation in surrounding brain tissue.

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Section: Discussionmentioning

confidence: 99%

Long-term Seizure Disorder Caused by a Dermoid Cyst with Catastrophic Developments

Alam

Mugge

Purdy

et al. 2018

Cureus

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“…Nazarov VV and Sahuc P et al reported 2 cases of patients with GBM in the same anatomical position as the previous meningioma resection. [ 8 , 9 ] In contrast to these patients, in the case we report herein, a new GBM developed in the contralateral cerebral hemisphere 3 years after meningioma resection. A review of the literature reveals that this is the first case of its type to be reported.…”

Section: Introductionmentioning

confidence: 60%

“…In addition, some researchers suggested that the occurrence of 2 tumors at the same time is accidental and that there is no definite correlation between the 2 tumors because they are among the most common tumors in the brain. [12] Moreover, Pauline Sahuc suggested that the occurrence of this condition may be related to the presence of some of the same signaling pathway abnormalities in both gliomas and meningiomas [9,13,14] ; however, the specific molecular mechanisms need to be further studied in these patients. Interestingly, in our case, and in contrast to similar cases previously reported, GBM did not occur in the same location but in the contralateral hemisphere after primary meningioma surgery without any systemic diseases or radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma in the contralateral cerebral hemisphere with previous surgery for meningioma: A case report

et al. 2023

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Rationale: Meningioma and glioblastoma (GBM) are 2 common intracranial tumors with different pathophysiologies and prognoses. It is rare for these 2 kinds of tumors to occur in the same patient. Most of the similar cases reported in the literature have been treated with radiotherapy, while cases without radiotherapy are rare. In particular, GBM in the contralateral cerebral hemisphere after resection of meningioma has not been reported.Patient concerns: We present a case of a 66-years-old man with GBM in the right temporal lobe after previous resection of a benign meningioma of the left frontal lobe without radiotherapy.Diagnoses: The patient was admitted to our hospital for the first time because of right upper limb weakness. Brain magnetic resonance imaging indicated a space-occupying lesion in the left frontal area. Surgical treatment was performed, and postoperative pathology confirmed a meningioma. The patient was readmitted to the hospital 3 years after surgery of the meningioma due to a new lesion of the right temporal lobe and underwent reoperation. The postoperative pathological results showed GBM. Interventions:The patient underwent 2 operations, and the postoperative pathologies were meningioma and GBM. In addition, the patient received concurrent chemoradiotherapy and 2 cycles of temozolomide adjuvant chemotherapy.Outcomes: During the last 4 months of follow-up, the patient was in good condition with no recurrence of the tumor.Lessons: The development of GBM without radiotherapy after meningioma surgery is very rare, especially at different sites, and it is necessary to accumulate relevant cases to reveal the causes of the disease and provide more evidence for the treatment of similar patients in the future.

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“…Nine case reports describing the transformation of meningioma to malignant high-grade glioma GBM were identified [Table 1]. [6,8,11,12,16,18,[21][22][23] In three cases, SRS-GK was used for treatment of meningioma. Age at the time of the initial lesion diagnosis ranged from 47 to 74 years.…”

Section: Resultsmentioning

confidence: 99%

Meningioma transformation to glioblastoma following stereotactic radiosurgery: A case report and review of the literature

Boyke,

Michel,

Garcia

et al. 2023

Surgical Neurology International

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Background: Meningiomas are the most common primary intracranial tumor with increasing incidence. Stereotactic Radiosurgery Gamma Knife (SRS-GK) is a commonly used modality for neoadjuvant and adjuvant treatment of these tumors and is often necessary for long-term disease control, particularly for the World Health Organization grade II/III meningiomas. While there is strong evidence to support the use of SRS-GK for meningioma, there exists a risk of secondary malignancy that is not well understood. We report a case of glioblastoma (GBM) that arose near the bed of a meningioma previously treated with SRS-GK and discuss other cases of GBM that emerged at a site of meningioma reported in the literature. Case Description: A 79-year-old female with a history of a blood-clotting disorder presented to the hospital with sudden facial sensory disturbances. On magnetic resonance imaging (MRI), a homogeneously enhancing lesion was observed in the right temporal lobe, consistent with a meningioma. Following 2 years of surveillance, the patient underwent SRS-GK for enlargement of the lesion. The patient later presented with headache and gait instability 12 years following SRS-GK. MRI revealed a large ring-enhancing lesion with surrounding edema histologically confirmed to be a GBM. At 9 months following initial tumor resection and a combination of radiotherapy and temozolomide, the patient was neurologically intact. Conclusion: There is a very small risk of meningioma to GBM conversion following SRS. Although SRS-GK poses a risk of secondary malignancy, there are some reported cases that underwent malignant transformation without SRS-GK. This suggests that SRS-GK is not the only factor in transformation and is a reasonable therapeutic modality to consider utilizing. Patients and their families should be appropriately counseled on the potential risks of radiation therapy, even for benign lesions like a meningioma.

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Glioblastoma Secondary to Meningioma: A Case Report and Literature Review

Cited by 7 publications

References 26 publications

Long-term Seizure Disorder Caused by a Dermoid Cyst with Catastrophic Developments

Long-term Seizure Disorder Caused by a Dermoid Cyst with Catastrophic Developments

Glioblastoma in the contralateral cerebral hemisphere with previous surgery for meningioma: A case report

Meningioma transformation to glioblastoma following stereotactic radiosurgery: A case report and review of the literature

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