2024
DOI: 10.1101/2024.10.17.618960
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Glioblastoma Treatment by Systemic Actinium-225 α-particle Dendrimer-radioconjugates is Improved by Chemotherapy

Rajiv Ranjit Nair,
Aira Sarkar,
Pooja Hariharan
et al.

Abstract: RATIONALE: The poor prognosis of glioblastoma is largely due to drug resistance and tumor location that, together, make it difficult to treat aggressively without affecting the rest of the brain. METHODOLOGY: High-energy, short-range (40-80μm) dendrimer-delivered α-particles could address both challenges, because (1) they cause complex, highly cytotoxic double-strand DNA breaks, and (2) irradiation of the neighboring brain is minimal, since dendrimers selectively delivers them to tumors. Since cancer cells tha… Show more

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