Glioblastoma with oligodendroglioma component in a ewe

Pintus, Davide; Marruchella, Giuseppe; Masia, Mariangela; Maestrale, Caterina; Cancedda, Maria Giovanna; Contu, Claudia; Macciocu, Simona; Ligios, Ciriaco

doi:10.1177/1040638716644646

Cited by 3 publications

(3 citation statements)

References 14 publications

(20 reference statements)

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“…The cellular origin of GB is unknown, but some studies suggest that it could be gener-ated from astrocytes, oligodendrocyte progenitor cells, and neural stem cells [2,3]. The limits of the tumor are diffuse everywhere and the name "multiform" refers to the variability of the histological morphology of GB, which has rounded and spindle-shaped cells, small or very large [4]. GB is characterized by a highly variable appearance due to the presence of small areas of necrotizing tissue that are surrounded by cells with poor cellular differentiation and tumor stem cells infiltrated by blood vessels (Fig.…”

Section: Glioblastoma Multiformementioning

confidence: 99%

The Effect of Glioblastoma on Pericytes

Molina

Valdor

2020

Curr. Tissue Microenviron. Rep.

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Purpose of the Review Intratumoral pericytes (PC) do not share the same tumor niche as peritumoral PC. Furthermore, glioblastoma multiforme (GB) cells do not seem to affect them equally. Therefore, for a better understanding of the effects of GB on PC, in this chapter, we will classify them according to whether they are intratumoral or peritumoral PC, focusing mainly on peritumoral effects, which seem to have better future prospects for finding effective therapies in GB cancer. Recent Findings Recently, it has been shown that PC could be the main target of the tumor infiltration front and have a fundamental role in the proliferation, expansion, and survival of the tumor, as well as in the regulation of anti-tumor immune responses. Modulation of the immune function of PC through molecular mechanisms such as chaperone-mediated autophagy (CMA) seems to be essential to prevent an immunosuppressive microenviroment that facilitates tumor growth. Summary GB is the most frequent and aggressive brain tumor. In the last years, PC have been gaining special attention due to their role in GB progression. GB cells infiltrate away from the tumor core more often and faster when they are associated with perivascular cells. However, to find targeted therapies against PC to promote their brain defense function and improve anti-tumor immune responses requires a better understanding of the heterogeneity, markers, and distribution of PC at origin.

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Section: Glioblastoma Multiformementioning

confidence: 99%

The Effect of Glioblastoma on Pericytes

Molina

Valdor

2020

Curr. Tissue Microenviron. Rep.

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“…In domestic animals, meningiomas are divided into subtypes, according to the morphological characteristics of the cells [5]. Initially, WHO classified domestic animal meningiomas into two categories: benign and malignant.…”

Section: Histopathological Classificationmentioning

confidence: 99%

“…The most frequently occurring IPTs in dogs and cats include gliomas, meningiomas, and choroid plexus tumors. The incidence of these tumors appears to be higher in dogs compared to cats: about 14.5 cases per 100,000 dogs and an estimated 3.5 cases per 100,000 cats [4,5]. The incidence is strongly correlated with the age of the animal, with IPTs occurring in middle-aged to older dogs and in older cats.…”

Section: Introductionmentioning

confidence: 97%

Domestic Animal Models of Central Nervous System Tumors: Focus on Meningiomas

Tomanelli,

Florio,

Vargas

et al. 2023

Life

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Intracranial primary tumors (IPTs) are aggressive forms of malignancies that cause high mortality in both humans and domestic animals. Meningiomas are frequent adult IPTs in humans, dogs, and cats, and both benign and malignant forms cause a decrease in life quality and survival. Surgery is the primary therapeutic approach to treat meningiomas, but, in many cases, it is not resolutive. The chemotherapy and targeted therapy used to treat meningiomas also display low efficacy and many side effects. Therefore, it is essential to find novel pharmacological approaches to increase the spectrum of therapeutic options for meningiomas. This review analyzes the similarities between human and domestic animal (dogs and cats) meningiomas by evaluating the molecular and histological characteristics, diagnosis criteria, and treatment options and highlighting possible research areas to identify novel targets and pharmacological approaches, which are useful for the diagnosis and therapy of this neoplasia to be used in human and veterinary medicine.

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ORF virus causes tumor-promoting inflammation in sheep and goats

Pintus,

Cancedda,

Puggioni

et al. 2024

Vet Pathol

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ORF virus (ORFV) causes contagious ecthyma (“ORF”), a disease of sheep and goats characterized by lesions ranging from vesicles and pustules to atypical papilloma-like and angiomatous lesions in the skin and mucosae. The authors investigated the molecular factors leading to the ORF-associated atypical tumor-like changes. Fifteen lambs, 15 kids, and an adult ram clinically affected by natural ORFV infection were enrolled in the study and examined by several methods. ORFV was detected by viral culture or real-time polymerase chain reaction (RT-PCR) in the lesioned tissues and in the blood of the clinically affected sheep and goats. Surprisingly, ORFV was also detected in the blood of healthy goats from an affected herd. Microscopically, they found a pseudo-papillomatous proliferation of the epithelium, while the dermis and lamina propria were expanded by a proliferating neovascular component that highly expressed the viral vascular endothelial growth factor (vVEGF) and its host receptor vascular endothelial growth factor receptor 2 (VEGFR2). Immunohistochemistry, immunofluorescence, and in situ hybridization for mRNA showed that epidermal growth factor receptor (EGFR) was expressed in the fibrovascular component, in the infiltrating CD163+ macrophages, and in the basal stratum of the epidermis. Confocal immunofluorescence microscopy demonstrated that CD163+ macrophages were associated with VEGF and VEGFR2. Finally, they found by quantitative RT-PCR the overexpression of the interleukin-6 and VEGFR2 genes in the lesioned tissues. These findings suggest that ORFV activates an inflammatory reaction characterized by CD163+ macrophages expressing EGFR and VEGFR2, which might play an oncogenic role through synergistic action with vVEGF signaling.

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Glioblastoma with oligodendroglioma component in a ewe

Cited by 3 publications

References 14 publications

The Effect of Glioblastoma on Pericytes

The Effect of Glioblastoma on Pericytes

Domestic Animal Models of Central Nervous System Tumors: Focus on Meningiomas

ORF virus causes tumor-promoting inflammation in sheep and goats

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