Glioblastoma with primitive neuronal component: Cytologic findings in intraoperative squash preparations

Borys, Ewa; Prabhu, Vikram C.; Pambuccian, Stefan E.

doi:10.1002/dc.23996

Cited by 6 publications

(8 citation statements)

References 9 publications

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“…On the one hand, they present areas of high-grade glial growth with high expression of gliofibrillar acid protein (GFAP) and, on the other hand, areas of undifferentiated neuroepithelial hypercellularity with low expression of GFAP and neuronal immunophenotype (S-100, synaptophysin, neuronal nuclei, neuron-specific enolase, and neurofilament protein). [2] Regarding imaging, although the MRI findings do not allow a distinction to be made between a "conventional" GB and a GB/PNC; the reduction of the apparent diffusion coefficient and the restriction in diffusion may be more evident probably due to the hypercellularity of the PNC. [1] In our case, it was not possible to determine the existence of a GB/PNC by MRI.…”

Section: Discussionmentioning

confidence: 99%

“…As with "conventional" GBs, they are considered Grade IV tumors according to the classification of CNS tumors of the WHO. [2] GB/PNC has characteristics of both types of tumor. As with "conventional" GBs, GB/PNC shows aggressive behavior with a high risk of local recurrence.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[ 6 ] Histologically, GB/PNC have characteristics of both entities, and some of the genetic alterations present in each type of tumor may coexist in GB/PNC. [ 2 ] The low prevalence of these tumors and few cases published to date make it difficult to understand the pathophysiology of GB/PNC and although there are therapeutic strategies for glioblastomas and tumors with PNC, there is currently no standard treatment regimen for GB/PNC. Most of the times, these tumors are treated with surgery combining radiation therapy and chemotherapy according to specific therapeutic regimes for glioblastomas and tumors with PNC.…”

Section: Introductionmentioning

confidence: 99%

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Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery

Ortega

Aguas-Valiente

Sota-Ochoa

et al. 2020

Surgical Neurology International

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Background: Glioblastoma with primitive neuronal components (GB/PNC) is an extremely rare type of glioblastoma characterized by presenting histological and cytogenetic features of both entities. The mixed nature of these tumors limits the imaging diagnosis and supposes a therapeutic dilemma. Case Description: We present the case of a 77-year-old female with a GB/PNC who is treated with surgery and adjuvant radiochemotherapy according to the STUPP protocol, where an abnormal uptake of 5-aminolevulinic acid (5-ALA) is evident during surgery in probable relation to the mixed nature of GB/PNC. Conclusion: GB/PNC is extremely rare tumors. Given its low prevalence, there are no studies that refer to the macroscopic characteristics of the tumor as well as evidence of the effectiveness of adjuvant treatment. Fluorescence-guided resection with 5-ALA is the surgical treatment of choice in surgery for high-grade gliomas; however, in GB/PNC, it may not be as useful since PNC may have less fluorescent marker uptake and be more dimly visualized when excited by light using the surgical microscope.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery

Ortega

Aguas-Valiente

Sota-Ochoa

et al. 2020

Surgical Neurology International

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“…The gross and histological depiction of glial tumors are often credited to the German pathologist Rudolph Virchow (born on October 13, 1821, and died on September 5, 1902), and while the first true histological description is truly his, gross descriptions can be traced back to the beginning of the 1800s in the English, French, and German scientific literature [1-4].…”

Section: Reviewmentioning

confidence: 99%

Hans Joachim Scherer and His Impact on the Diagnostic, Clinical, and Modern Research Aspects of Glial Tumors

Stoyanov

Petkova

Dzhenkov

2019

Cureus

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The historical descriptions of glial tumors are often poorly understood and interpreted. The gross and histological depictions of glial tumors are often credited to Virchow, and while the first true histological description is truly his, gross descriptions can be traced back to the beginning of the 1800s, with their classification and histogenesis attributed to Percival Bailey and Harvey Cushing. Without any question, the most prominent and under-credited researcher in the field of glioma pathobiology was the German neuropathologist Hans Joachim Scherer. Despite the limited armamentarium available to him, his systematic approach led to conclusions, some of which have now been molecularly explained today while some are still being widely researched. Scherer defined pseudopalisadic necrosis as a pathognomonic feature of glioblastoma multiforme (GBM), as well as secondary features due to tumor growth, known collectively as secondary Scherer figures, for example, neuronal and vascular satellitosis, tract and subpial aggregation. All these features are key points in the modern histological diagnosis of glial tumors. Other contributions by Scherer include the definition of glomeruloid vascular proliferation and his conclusion that they are caused by vascular factors released by the tumor, decades before vascular endothelial growth factor and its receptors were discovered and their role in glioma evolution was established. Furthermore, he concluded that GBMs can arise de novo (primary) or from a preceding lower-grade glioma (secondary). All his contributions find their place in all modern aspects of glioma research, with some giving a simple explanation of the phenomena observed in glial tumors.

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Glioblastoma mimicking metastatic small cell carcinoma: A case report with ultrastructural findings

Maekawa

Tokumitsu

Noguchi

et al. 2021

Diagnostic Cytopathology

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It is often straightforward to distinguish glioblastoma (GBM) from metastatic carcinoma by cytology; however, small cell variants of GBM or GBM with primitive neuronal component (GBMPNC) can mimic metastatic small cell carcinoma (SCC). Herein, we report a case of GBMPNC mimicking metastatic SCC and present cytological and ultrastructural findings. A 65‐year‐old man with memory disturbance was hospitalized. Magnetic resonance imaging revealed the presence of a 6 cm sized tumor in the right anterior temporal lobe. Intraoperative cytology slides indicated that the tumor consisted of small‐sized cells with scant cytoplasm showing high cellularity. The initial intraoperative diagnosis was metastatic SCC; however, any primary visceral tumor was not detected clinically. Immunohistochemical and ultrastructural studies of postoperative histological sections revealed that the lesion was GBMPNC. This case shows that some GBMs may have the potential to closely mimic metastatic SCC, which expands the differential diagnosis and emphasizes the importance of clinical correlation.

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Glioblastoma with primitive neuronal component: Cytologic findings in intraoperative squash preparations

Cited by 6 publications

References 9 publications

Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery

Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery

Hans Joachim Scherer and His Impact on the Diagnostic, Clinical, and Modern Research Aspects of Glial Tumors

Glioblastoma mimicking metastatic small cell carcinoma: A case report with ultrastructural findings

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