Glioblastoma with primitive neuronal component: An immunohistochemical study and review of literature

Poyuran, Rajalakshmi; Kesavadas, Chandrasekharan; Easwer, H. V.; Narasimhaiah, Deepti

doi:10.1016/j.jocn.2021.09.004

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Histologic variants of glioblastomas include the following: a giant cell subtype characterized by bizarre multinucleated giant cells, a sarcomatous subtype that is termed "gliosarcoma" (Figure 4D), an epithelioid subtype with abundant eosinophilic cytoplasm and distinct cell borders (Figure 4E), a granular cell subtype characterized by a PAS-positive granular cytoplasm, and a small cell type that can resemble a high-grade oligodendroglioma [77][78][79]. Other possible histological features include glioblastomas possessing a primitive neuronal component, epithelial metaplasia, or adipocytic differentiation [80][81][82][83].…”

Section: Histology and Diagnostic Workupmentioning

confidence: 99%

“…Conventional glioblastomas are immunoreactive for GFAP, however, there is an inconsistent staining pattern of GFAP and, sometimes, a complete loss of expression in several of the histological subtypes is observed [79,80,86]. By definition, glioblastomas are IDH-wildtype and H3-wildtype tumours, thus immunoreactivity for IDH1 R132H and H3 p.K28M (K27M) is negative.…”

Section: Histology and Diagnostic Workupmentioning

confidence: 99%

“…IDH-wildtype glioblastomas are grade 4 tumours that are histologically characterized by high-grade features, such as microvascular proliferation and necrosis. A major change in WHO CNS5 is the designation of IDH-wildtype and H3-wildtype astrocytic Conventional glioblastomas are immunoreactive for GFAP, however, there is an inconsistent staining pattern of GFAP and, sometimes, a complete loss of expression in several of the histological subtypes is observed [79,80,86]. By definition, glioblastomas are IDH-wildtype and H3-wildtype tumours, thus immunoreactivity for IDH1 R132H and H3 p.K28M (K27M) is negative.…”

Section: Grading and Molecular Integration For Diagnosis And Prognosismentioning

confidence: 99%

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From Theory to Practice: Implementing the WHO 2021 Classification of Adult Diffuse Gliomas in Neuropathology Diagnosis

Martin

Yip

2023

Brain Sciences

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Diffuse gliomas are the most common type of primary central nervous system (CNS) neoplasm to affect the adult population. The diagnosis of adult diffuse gliomas is dependent upon the integration of morphological features of the tumour with its underlying molecular alterations, and the integrative diagnosis has become of increased importance in the fifth edition of the WHO classification of CNS neoplasms (WHO CNS5). The three major diagnostic entities of adult diffuse gliomas are as follows: (1) astrocytoma, IDH-mutant; (2) oligodendroglioma, IDH-mutant and 1p/19q-codeleted; and (3) glioblastoma, IDH-wildtype. The aim of this review is to summarize the pathophysiology, pathology, molecular characteristics, and major diagnostic updates encountered in WHO CNS5 of adult diffuse gliomas. Finally, the application of implementing the necessary molecular tests for diagnostic workup of these entities in the pathology laboratory setting is discussed.

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Section: Histology and Diagnostic Workupmentioning

confidence: 99%

Section: Histology and Diagnostic Workupmentioning

confidence: 99%

Section: Grading and Molecular Integration For Diagnosis And Prognosismentioning

confidence: 99%

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From Theory to Practice: Implementing the WHO 2021 Classification of Adult Diffuse Gliomas in Neuropathology Diagnosis

Martin

Yip

2023

Brain Sciences

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How is Rosette Formation in Brain Tumours Linked with Cerebrospinal Fluid Spread?

Kumaria,

Ashkan,

Macarthur

2024

Preprint

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Glioblastoma with a primitive neuronal component: A case report

Liu

Sun

et al. 2023

Oncol Lett

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The present study describes a rare case of glioblastoma with a primitive neuronal component (GBM-PNC), and provides an in-depth analysis of the clinical, pathological and differential diagnostic findings. A comprehensive literature review was conducted to enhance the understanding of GBM-PNC, revealing its distinct characteristics and prognostic implications. A 57-year-old woman presented with acute onset headache, nausea and vomiting, leading to the identification of an intracranial mass through magnetic resonance imaging. Surgical resection revealed the coexistence of a glial component and a PNC within the tumor. Immunohistochemical analysis detected the expression of glial fibrillary acidic protein in the glial component and synaptin in the PNC. The pathological diagnosis confirmed the presence of GBM-PNC. Gene detection analysis revealed no mutations in isocitrate dehydrogenase (IDH)1 and IDH2, and neurotrophic tyrosine kinase receptor-1 (NTRK1), NTRK2 and NTRK3 genes. GBM-PNC is characterized by a propensity for recurrence and metastasis, with a low 5-year survival rate. The present case report highlights the importance of accurate diagnosis and comprehensive characterization of GBM-PNC to guide treatment decisions and improve patient outcomes.

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Glioblastoma with primitive neuronal component: An immunohistochemical study and review of literature

Cited by 4 publications

References 32 publications

From Theory to Practice: Implementing the WHO 2021 Classification of Adult Diffuse Gliomas in Neuropathology Diagnosis

From Theory to Practice: Implementing the WHO 2021 Classification of Adult Diffuse Gliomas in Neuropathology Diagnosis

How is Rosette Formation in Brain Tumours Linked with Cerebrospinal Fluid Spread?

Glioblastoma with a primitive neuronal component: A case report

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