Glioma and glioblastoma - how much do we (not) know?

Jovčevska, Ivana; Kočevar, Nina; Komel, Radovan

doi:10.3892/mco.2013.172

Cited by 158 publications

(118 citation statements)

References 97 publications

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“…The prognosis of astrocytoma differs according to features such as age, disease stage, and histological type. GBM is the most malignant astrocytoma, with a median overall survival (OS) of approximately 12 months and a 5‐year OS of 4.8%‐5.4%,1, 2, 3 while patients suffering from anaplastic astrocytoma have a median OS of 38 months and a 5‐year OS of 25.9%‐41.1% 1, 4. A deeper understanding of the prognostic factors of GBM may provide new ideas for the prevention and management of this disease.…”

Section: Introductionmentioning

confidence: 99%

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

et al. 2018

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The relationship between marital status and glioblastoma multiforme (GBM) has not been addressed in depth. Here, we aimed to investigate the association between marital status and survival in GBM. We searched the Surveillance, Epidemiology, and End Results (SEER) database and extracted the data of eligible patients diagnosed with GBM after 2004. Marital status was classified as married, divorced/separated, widowed, and single. A Kaplan‐Meier test was conducted to compare the survival curves of different groups. Multivariate Cox regression was performed to evaluate overall survival (OS) and cause‐specific survival (CSS) in different groups. Subgroup analysis was applied according to demographics, typical education and income levels in the locale, and insurance status. A total of 30 767 eligible patients were included. The median OS values were 9, 7, 3, 9 months in married, divorced/separated, widowed, and single patients, respectively. After adjustment for other covariates, married patients had better OS and CSS than other patients had. In addition to marital status, demographic factors, disease progression factors, local educational level, and insurance status were also associated with survival in GBM. Furthermore, subgroup analyses revealed the protective effect of marriage in most of the comparisons. Notably, the protective effect of marriage becomes more and more apparent as time goes on. The advantageous effect of marriage on GBM survival is especially prominent in patients who are male, older than 60 years of age, White, or living in middle‐income counties. In conclusion, marital status is an independent prognostic factor for GBM.

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Section: Introductionmentioning

confidence: 99%

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

et al. 2018

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“…Patients diagnosed with astrocytoma grade III and GBM have a 5-year median survival rate of 26.5% and 4.7%, respectively (Ostrom et al, 2013). The extremely low survival rate of GBM patients is caused by high levels of invasion of tumorogenic cells into the surrounding tissue and high resistance to therapies (Jovčevska et al, 2013). Current median survival rates, when compared with those in 1995-1998, have increased by approximately 4 months (Mazaris et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Analysis of oncogene GLI1 protein expression levels between differing grades of astrocytoma

Gricius¹,

Kazlauskas²

2014

biologija

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Aberrant expression of oncogene GLI1 has been linked to malignancies in many types of tissues including brain, pancreas, skin and breast. It has been found that GLI1 expression is important for tumor progression and has been linked to tumor grade. In this study, GLI1 expression has been analyzed in different malignancy grade astrocytomas.GLI1 protein expression has been evaluated in 87 clinical tumor samples by using Western blot analysis. Associations between GLI1 expression and tumor grade were analyzed by applying Mann-Whitney or Kruskal-Wallis tests. KaplanMeier survival analysis was performed to evaluate the prognosis of patients.Western blot analysis did not show statistically significant correlation between GLI1 protein expression and astrocytoma tumor grade (P = 0.294). Kaplan-Meier survival also did not show correlation between survival rates and GLI1 expression (P = 0.081). Our results show that GLI1 protein expression levels in astrocytomas have higher variability than previously shown.Our results indicate that GLI1 protein expression is not an absolute requirement for the process of gliomagenesis. Yet, a relatively high (52%) occurrence of GLI1 expression in astrocytomas suggests the need for further analysis on the involvement of GLI1-mediated Hedgehog signaling pathway in glioma tumorogenesis.

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“…In the past decade, the median survival of glioma patients has remained stable at 12 months or less (2). Previous studies on glioma mostly have focused on histopathology and molecular biology, and few have aimed at the systematic investigation of the correlation between tumor cell phenotype and the function nature in tumor tissue (3).…”

Section: Introductionmentioning

confidence: 99%

Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression

et al. 2015

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Abstract. Mangiferin, a flavonoid extracted from the leaves of the Anacardiaceae plant, the mango tree, has physiological activity and pharmacological effects in many aspects. The present study aimed to clarify the effect of mangiferin on proliferation and apoptosis of glioma cells and the mechanism of these curative effects of mangiferin. In this experiment, we detected the proliferation using 3-(4,5-dimethylthylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay. Then, cell apoptosis of U87 glioma cells was measured with the Annexin V-FITC/propidium iodide (PI) apoptosis detection kit, DAPI staining assay and the caspase-3 and caspase-9 activity assay kit. Next, quantitative real-time PCR and gelatin zymography were used to analyze the expression of microRNA-15b (miR-15b) and matrix metalloproteinase-9 (MMP-9), respectively. MMP-9 agonist, miR-15b mimics and anti-miR-15b mimics were added to the U87 glioma cells for elucidating the mechanisms involved in the curative effects of mangiferin. In the present study, mangiferin notably restrained the proliferation and increased the apoptosis of the U87 glioma cells. Meanwhile, mangiferin specifically promoted the expression of miR-15b and suppressed the level of MMP-9 in the U87 glioma cells. miR-15b regulated the expression of MMP-9 in the U87 glioma cells. MMP-9 agonist and antimiR-15b reduced the curative effects of mangiferin in the U87 glioma cells. In summary, mangiferin regulates proliferation and apoptosis in glioma cells by induction of miR-15b and inhibition of MMP-9 expression.

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Glioma and glioblastoma - how much do we (not) know?

Cited by 158 publications

References 97 publications

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

Analysis of oncogene GLI1 protein expression levels between differing grades of astrocytoma

Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression

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