Glioma Epidemiology in the Central Tunisian Population: 1993-2012

Trabelsi, Saoussen; Brahim, Dorra H’mida-Ben; Ladib, M.; Mama, N.; Harrabi, Imed; Tlili, Kalthoum; Yacoubi, Mohamed Tahar; Krifa, H.; Hmissa, Sihem; Saâd, Ali; Mokni, Moncef

doi:10.7314/apjcp.2014.15.20.8753

Cited by 19 publications

(15 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glioma is the most common malignant tumor of the central nervous system with a high recurrence rate and low survival rate (1,2). Despite the great advances in treatment strategies over the last decades, the prognosis of glioma remains unsatisfactory (3,4). Therefore, a deeper understanding of the molecular mechanisms involved in glioma tumorigenesis is urgently required.…”

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

et al. 2019

Exp Ther Med

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) are hypothesized to regulate numerous biological behaviors in human cancers. The present study aimed to explore the roles of lncRNA bladder cancer associated transcript 1 (BLACAT1) in glioma. The expression of BLACAT1 in glioma tissues and cell lines was determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). CCK-8 assay, colony formation assay, wound healing assay and Transwell invasion assay were used to explore the roles of BLACAT1 in glioma cells. RT-qPCR and western blot analysis were used to determine the BLACAT1 molecular mechanism. The findings demonstrated that lncRNA BLACAT1 was overexpressed in glioma tissues and cell lines. High BLACAT1 expression was correlated with high tumor grade in glioma patients. Functional assays determined that BLACAT1 promoted glioma cell proliferation, migration, invasion and epithelial-mesenchymal transition in vitro. In addition, it was demonstrated that BLACAT1 activated the Wnt/β-catenin signaling pathway. In conclusion, BLACAT1 may serve as an oncogenic lncRNA in glioma progression via activation of the Wnt/β-catenin signaling pathway. Therefore, BLACAT1 may be a novel therapeutic target for glioma treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

et al. 2019

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Concerning age, the Algerian glioma population (mean = 48, median = 49 years) was found younger than the French (median = 58 years) and the American (mean = 51.9), close to the Tunisian (median = 48) and older than the Chinese (median = 41) [11][12][13][14] . Moreover, the decrease of the number of observed cases in the old adult age group is also reported in the Tunisian, and the Asian populations and is in contrast with the Euro-pean, the American and the Canadian findings, where no decrease was observed 4,6,11,[15][16][17] . This difference may be explained by variations in life expectancy at birth between developed and developing countries or by disparity in availability of health care 18 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and survival analyses of 333 adult glioma patients from Eastern Algeria (2008-2016)

Touati¹,

Djekkoun²,

Okki³

et al. 2020

Afr H. Sci.

View full text Add to dashboard Cite

Background: Gliomas are a relatively rare group of tumors with a poor prognosis. We aimed to describe and analyze the clinical characteristics and survival of patients with glioma tumors of Eastern Algeria. Methods: A retrospective study was conducted at the University Hospital of Constantine. Medical records of patients enrolled between January 2008 and October 2016 were consulted. Demographic characteristics, clinical data, treatment strategy and dates of last follow-up or death were collected. Chi-square test was used for checking associations, Kaplan- Meier methodology for estimating the survival, and the cox model for identifying prognosis factors. Results: A total of 333 patients composed our cohort. The mean age was 48.07 years, and men were 1.87 times more frequent than women. High grade tumors were mainly observed among adults and old adults and in supra-tentorial locations. More than half of the patients had a large resection and a curative protocol of oncological treatment (50.7% and 57%, re- spectively). The mean overall survival was 45.4 months, the median was 21.7 months, and survival rates at 1-, 2-, and 5-years were: 62.8%, 48.5% and 32.9% respectively. Age, histology, grade of malignancy and oncological treatment were the major prognosis factors. Conclusion: Our sample was relatively young with a higher survival compared to others. Keywords: Glioma; epidemiology; Algeria.

show abstract

“…Glioma encompasses different histological subtypes with high variability in prognosis and accounts for almost 80 % of primary malignant brain tumors [ 20 ]. At present, the causes for glioma tumorigenesis and aggressiveness remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Insights into the clinical value of cyclin-dependent kinase 5 in glioma: a retrospective study

et al. 2015

View full text Add to dashboard Cite

BackgroundPrevious studies suggested that expression of cyclin-dependent kinase 5 (CDK5) may promote the migration and invasion of human glioma cells. In this study, we aimed to evaluate the clinical value of CDK5 in different grades of glioma in relation to Ki-67 labeling index (LI).MethodsWe firstly assessed by immunohistochemistry the expression of CDK5 in 152 glioma tissues and 16 normal brain tissues and further explored the relationship between CDK5 expression and other clinical features.ResultsThe positive ratio of CDK5 in gliomas (57.2 %) was higher than that in normal brain tissues (12.5 %, P = 0.001). Difference of CDK5 expression among four World Health Organization (WHO) grades was statistically significant (P = 0.001). The significant differences of CDK5 expression were also observed between WHO I glioma (34.8 %) and WHO III glioma (62.5 %), as well as WHO IV glioma (82.8 %; P = 0.026, P < 0.001, respectively). Furthermore, Spearman’s rank correlation confirmed that CDK5 was positively correlated with the pathological grade of glioma (r = 0.831, P < 0.001). The CDK5 expression was also positively correlated with Ki-67 LI (r = 0.347, P < 0.001).ConclusionsThe current result suggests that CDK5 may play an essential role in the tumorigenesis and aggressiveness of gliomas.

show abstract

Glioma Epidemiology in the Central Tunisian Population: 1993-2012

Cited by 19 publications

References 14 publications

Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

Long non‑coding RNA BLACAT1 promotes the proliferation and invasion of glioma cells via Wnt/β‑catenin signaling

Epidemiology and survival analyses of 333 adult glioma patients from Eastern Algeria (2008-2016)

Insights into the clinical value of cyclin-dependent kinase 5 in glioma: a retrospective study

Contact Info

Product

Resources

About