Glioma of the Diencephalon in a Manic Patient

Stern, Karl; Dancey, Travis E.

doi:10.1176/ajp.98.5.716

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Brain Tumors1

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2016

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Cited by 25 publications

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“…Features. We identified 16 case reports on mania in people with brain tumors (48)(49)(50)(51)(52)(53)(54)(55). Multiple tumor types were implicated, roughly paralleling their prevalence in the general population, suggesting that tumor histology does not play a role in mania.…”

Section: Brain Tumorsmentioning

confidence: 99%

Mania secondary to focal brain lesions: implications for understanding the functional neuroanatomy of bipolar disorder

2016

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Secondary mania should be suspected in patients with neurological deficits, histories atypical for classic bipolar disorder, and first manic episodes after the age of 40 years. Treatment with antimanic medications, along with specific treatment for the underlying neurologic condition, is typically required. Typical lesion locations fit with current models of bipolar disorder, which implicate hyperactivity of left-hemisphere reward-processing brain areas and hypoactivity of bilateral prefrontal emotion-modulating regions. Lesion studies complement these models by suggesting that right-hemisphere limbic-brain hypoactivity, or a left/right imbalance, may be relevant to the pathophysiology of mania.

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