Glioma Therapy: Combination Glioma Therapy Mediated by a Dual‐Targeted Delivery System Constructed Using OMCN–PEG–Pep22/DOX (Small 42/2018)

Abstract

In article number https://doi.org/10.1002/smll.201801905, Jinlong Shi, Rongqin Huang, Wei Shi, and co‐workers describe a novel drug‐loaded system, OPPD, which uses PEG and OMCN linked to the Pep22 polypeptide targeting the low‐density lipoprotein receptor, that can effectively cross the blood‐brain barrier and target glioma cells, exerting an outstanding therapeutic efficacy via both the near‐infrared photothermal and chemotherapeutic effects of the loaded DOX. The collective findings support the utility of OPPD, a promising drug‐delivery vehicle, for future clinical application in glioma therapy.