Gliomatosis cerebri: a consensus summary report from the Second International Gliomatosis cerebri Group Meeting, June 22–23, 2017, Bethesda, USA

Madrid, Andrés Morales La; Ranjan, Surabhi; Warren, Katherine E.

doi:10.1007/s11060-018-2938-x

Cited by 12 publications

(10 citation statements)

References 19 publications

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“…Treatment is challenging due to the extensiveness and irresectability of the lesion. Radiation therapy is especially restricted due to the extensive involvement, which often requires dosage adjusting, decreased length of therapy, and have a high likelihood of causing neurotoxicities [3]. Lower doses of ionizing radiation may also reduce the effectiveness of chemotherapy, as the length of concurrent radiation can be reduced.…”

Section: Discussionmentioning

confidence: 99%

Gliomatosis cerebri

García

Villanó

2019

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 99%

Gliomatosis cerebri

García

Villanó

2019

Journal of Clinical Neuroscience

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“…8 However, we cannot ignore the invasive radiological features of GC, and further study is required to understand this unique tumor. 9 We report a case that clinically and radiologically corresponded to the diagnosis of GC, with minimal or some findings of glial hyperplasia histologically. Immunohistochemical analyses did not show positivity in IDH1R132H or TP53, but molecular analysis showed a point mutation at mtDNA of LHON.…”

mentioning

confidence: 86%

Leber’s hereditary optic neuropathy with diffuse white matter changes mimicking gliomatosis cerebri: illustrative case

Saruta¹,

Shibahara²,

Handa³

et al. 2021

Journal of Neurosurgery: Case Lessons

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BACKGROUIND Leber’s hereditary optic neuropathy (LHON) is a mitochondrial disease characterized by bilateral severe subacute central vision loss and a mutation in the mitochondrial DNA (mtDNA). The findings on cranial magnetic resonance imaging of patients with LHON vary from subtle to multiple white matter changes. However, they rarely present with diffuse infiltrative white matter changes. OBSERVATIONS The authors reported a case with diffuse white matter changes mimicking gliomatosis cerebri (GC). The histological findings included only mild glial hyperplasia without immunohistochemical positivity, supporting the diagnosis of glial tumors. Analysis of mtDNA obtained from the blood and brain tissue revealed mutation of m.11778G>A in the NADH dehydrogenase 4 gene, which confirmed the case as LHON. Immunohistochemistry of the brain tissue revealed 8-hydroxy-2′-deoxyguanosine positivity, suggesting the presence of oxidative stress. LESSONS LHON is extremely difficult to diagnose unless one suspects or knows the disease. The present case brings attention not only to LHON but also to other mtDNA-mutated diseases that need to be considered with diffuse white matter changes or GC.

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“…In the revised WHO Classification of Tumors of the Central Nervous System (2016), GC is no longer defined as a single entity and several new entities including “diffuse midline glioma with H3 K27M‐mutant” have been introduced 1 . The term “GC,” however, is still used to describe its characteristic growth pattern 2‐4 . As previously reported, GC is neither pathologically nor genetically grouped into a single entity, but most cases share molecular abnormalities commonly found in other gliomas including hot spot mutations and methylation signatures.…”

Section: Figurementioning

confidence: 99%