Gliomatosis cerebri type II: two case reports

D’Urso, Pietro Ivo; D’Urso, Oscar Fernando; Marsigliante, Santo; Storelli, Carlo; Distante, A.; Sanguedolce, Francesca; Cimmino, Antonietta; Luzi, G.; Gianfreda, Cosimo Damiano; Montinaro, Antonio; Ciappetta, Pasqualino

doi:10.4076/1752-1947-3-7225

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…In a case series, 1 iteration of type II gliomatosis cerebri demonstrated overexpression of vascular endothelial growth factor and vascular cell adhesion molecule I along with a high degree of neoangiogenesis. 66 Along these lines, in a 2009 cohort of gliomatosis cerebri patients, Seiz and colleagues reported 6 patients with histopathological evidence of vascular endothelial growth factor and cyclooxygenase 2 expression. Four of these patients were then treated with an antiangiogenic (celecoxib) in addition to low-dose chemotherapy (temozolomide) following radiation therapy and subsequently demonstrated favorable outcomes.…”

Section: Molecular Profilementioning

confidence: 99%

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Pediatric Gliomatosis Cerebri: A Review of 15 Years

et al. 2015

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Gliomatosis cerebri is a rare glial tumor that carries a poor prognosis. Seen in both adults and children, gliomatosis cerebri appears to differ in these populations as with adult versus pediatric glioblastoma. We present 10 children who either presented to the Weill Cornell Medical College or enrolled in the institution's Gliomatosis Cerebri International Registry alongside a cohort of 89 pediatric patients reported in the literature between 2000 and 2014. Age ranged from 4 months to 21 years, with a male to female ratio of 1.71. Median overall survival for patients in the registry cohort was 17 months (n = 10) and for the historic cohort was 13 months (n = 52). Overall survival was analyzed for the combined cohort and was significantly longer when presenting at age ≥ 10 (20 vs 10 months), for boys (18 vs 11 months), and with low-grade pathology (26.5 vs 12 months) but did not vary significantly by treatment approach.

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Section: Molecular Profilementioning

confidence: 99%

“…As with TP53 and PTEN, aberrant epidermal growth factor receptor has been examined in a small number of studies without significant conclusions. 18,66,71…”

Section: Molecular Profilementioning

confidence: 99%

Pediatric Gliomatosis Cerebri: A Review of 15 Years

et al. 2015

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“…Dear Editor, Glioblastoma cerebri (GB) is aggressive tumor of uncertain origin which infiltrates three or more lobes, spreads on both hemispheres, complicates with brain edema (BE) and hemorrhagia. 1 We report the first case of HD patient with GB.…”

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confidence: 90%

“…Dear Editor, Post-disaster stress negatively affects the control of blood pressure by increasing salt intake. 1,2 Immediately after a major earthquake, the risk of cardiovascular diseases increases. 3 These increases are not observed over subsequent years.…”

Section: Late Increases In Dialysis Initiation After a Massive Disastermentioning

confidence: 99%

Challenge of hemodialysis: A patient with glioblastoma cerebri, cerebral edema, and hemorrhagic stroke

et al. 2020

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Molecular mechanisms underlying gliomas and glioblastoma pathogenesis revealed by bioinformatics analysis of microarray data

Vastrad¹,

Vastrad

Godavarthi³

et al. 2017

Med Oncol

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The aim of this study was to identify key genes associated with gliomas and glioblastoma and to explore the related signaling pathways. Gene expression profiles of three glioma stem cell line samples, three normal astrocyte samples, three astrocyte overexpressing 4 iPSC-inducing and oncogenic factors (myc(T58A), OCT-4, p53DD, and H-Ras(G12V)) samples, three astrocyte overexpressing 7 iPSC-inducing and oncogenic factors (OCT4, H-Ras(G12V), myc(T58A), p53DD, cyclin D1, CDK4(RC24) and hTERT) samples and three glioblastoma cell line samples were downloaded from the ArrayExpress database (accession: E-MTAB-4771). The differentially expressed genes (DEGs) in gliomas and glioblastoma were identified using FDR and t tests, and protein-protein interaction (PPI) networks for these DEGs were constructed using the protein interaction network analysis. The GeneTrail2 1.5 tool was used to identify potentially enriched biological processes among the DEGs using gene ontology (GO) terms and to identify the related pathways using the Kyoto Encyclopedia of Genes and Genomes, Reactome and WikiPathways pathway database. In addition, crucial modules of the constructed PPI networks were identified using the PEWCC1 plug-in, and their topological properties were analyzed using NetworkAnalyzer, both available from Cytoscape. We also constructed microRNA-target gene regulatory network and transcription factor-target gene regulatory network for these DEGs were constructed using the miRNet and binding and expression target analysis. We identified 200 genes that could potentially be involved in the gliomas and glioblastoma. Among them, bioinformatics analysis identified 137 up-regulated and 63 down-regulated DEGs in gliomas and glioblastoma. The significant enriched pathway (PI3K-Akt) for up-regulated genes such as COL4A1, COL4A2, EGFR, FGFR1, LAPR6, MYC, PDGFA, SPP1 were selected as well as significant GO term (ear development) for up-regulated genes such as CELSR1, CHRNA9, DDR1, FGFR1, GLI2, LGR5, SOX2, TSHR were selected, while the significant enriched pathway (amebiasis) for down-regulated gene such as COL3A1, COL5A2, LAMA2 were selected as well as significant GO term (RNA polymerase II core promoter proximal region sequence-specific binding (5) such as MEIS2, MEOX2, NR2E1, PITX2, TFAP2B, ZFPM2 were selected. Importantly, MYC and SOX2 were hub proteins in the up-regulated PPI network, while MET and CDKN2A were hub proteins in the down-regulated PPI network. After network module analysis, MYC, FGFR1 and HOXA10 were selected as the up-regulated coexpressed genes in the gliomas and glioblastoma, while SH3GL3 and SNRPN were selected as the down-regulated coexpressed genes in the gliomas and glioblastoma. MicroRNA hsa-mir-22-3p had a regulatory effect on the most up DEGs, including VSNL1, while hsa-mir-103a-3p had a regulatory effect on the most down DEGs, including DAPK1. Transcription factor EZH2 had a regulatory effect on the both up and down DEGs, including CD9, CHI3L1, MEIS2 and NR2E1. The DEGs, such as MYC, FGFR1, CDKN2A, HOXA10 and MET,...

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Gliomatosis cerebri type II: two case reports

Cited by 3 publications

References 3 publications

Pediatric Gliomatosis Cerebri: A Review of 15 Years

Pediatric Gliomatosis Cerebri: A Review of 15 Years

Challenge of hemodialysis: A patient with glioblastoma cerebri, cerebral edema, and hemorrhagic stroke

Molecular mechanisms underlying gliomas and glioblastoma pathogenesis revealed by bioinformatics analysis of microarray data

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