Gliomatosis of the brain and spinal cord masquerading as infective lesions

Meligonis, George; Sur, Monalisa; Ouma, John R.; Grayson, Wayne; Farrell, Victor J.

doi:10.1016/s0090-3019(02)00707-3

Cited by 17 publications

(8 citation statements)

References 10 publications

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“…A point of interest in the present case is the lumbosacral spinal cord lesion and absence of lesions in the cervicothoracic spinal cord on MRimages. To our knowledge, there are only four other cases of GCdemonstrating a spinal cord lesion on MRimages (5, [15][16][17]. These cases showed a high signal intensity area in the spinal cord from cervical to thoracic or lumbar levels on T2-weighted MR images.…”

Section: Discussionmentioning

confidence: 90%

“…Consequently, radiographic images and MRspectroscopy is useful for a possible diagnosis, but brain biopsy is essential for definitive antemortem diagnosis as described previously (3, 4). There are several case reports of GCinvolving the spinal cord (5, [15][16][17][18][19]. In those cases, it was difficult to distinctly separate the symptomsof the brain lesion and those of the spinal cord lesion, but the salient clinical feature caused by the spinal cord lesion seems to be muscle weaknessand GC involving the spinal cord is occasionally misdiagnosed as motor neuron disease (18,19).…”

Section: Discussionmentioning

confidence: 99%

“…These cases showed a high signal intensity area in the spinal cord from cervical to thoracic or lumbar levels on T2-weighted MR images. One case showed leptomeningeal enhancement (5) and another case showed diffuse enhancement of the arachnoid space (17). Postmortem examination was carried out in three cases and widespread infiltration was demonstrated in the spinal cords (5, 16,17).…”

Section: Discussionmentioning

confidence: 99%

“…One case showed leptomeningeal enhancement (5) and another case showed diffuse enhancement of the arachnoid space (17). Postmortem examination was carried out in three cases and widespread infiltration was demonstrated in the spinal cords (5, 16,17). Furthermore, it was reported in one case that the spinal cord lesion was neither due to dissemination via the CSF nor multicentric origin but due to infiltration along the nerve fiber tracts (5).…”

Section: Discussionmentioning

confidence: 99%

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Gliomatosis Cerebri Involving the Lumbosacral Spinal Cord

et al. 2003

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gliomatosis Cerebri Involving the Lumbosacral Spinal Cord

et al. 2003

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“…Weiter erm ö glicht die Spektroskopie eine genauere Abgrenzung von akuten entz ü ndlichen Prozessen und hirneigenen Tumoren, die in der konventionellen Magnetresonanztomographie eine sehr ä hnliche Bildmorphologie aufweisen k ö nnen. Insbesondere diffus infi ltrativ wachsende gliomat ö se zerebrale Tumoren k ö nnen kernspintomographisch cham ä leonartig infekti ö se und autoimmun-entz ü ndliche Zerebralprozesse vort ä uschen [6] . Cholin stellt einen Marker f ü r den Membranphospholipidmetabolismus, Kreatin-/ Kreatinphosphat f ü r den Energiemetabolismus und N-Acetyl-Aspartat (NAA) f ü r die Synthese beziehungsweise f ü r den Abbau von neuronenspezifi schen Aminos ä urederivaten dar.…”

Section: Diskussionunclassified

Differenzialdiagnostische Abgrenzung Enzephalitis versus Gliom mittels Magnetresonanzspektroskopie

Parbel¹,

Vlaho²,

Gebhardt³

et al. 2007

Klin Padiatr

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Gliomatosis cerebri: 20 Years of experience at the Children's Hospital of Philadelphia

Armstrong¹,

Phillips²,

Rorke-Adams³

et al. 2006

Cancer

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BACKGROUND.Gliomatosis cerebri (GC) is a rare and typically fatal glial neoplasm of the central nervous system. In this report, the authors describe the largest cohort of children to date with GC and explore relations between potential prognostic factors, treatment, and survival.METHODS.Imaging, pathologic, and outcome data were reviewed from 13 patients who were diagnosed with GC and were treated at the Children's Hospital of Philadelphia (CHOP) between 1982 and 2005. All patients had GC confirmed by biopsy. Twelve patients received cranial irradiation, and 8 of those patients received adjuvant chemotherapy. A single patient age 1 year received chemotherapy alone. A review of the literature identified 51 pediatric patients with GC.RESULTS.The progression‐free survival rate in this study was 13% (range, 1.5–43 months), and the overall survival (OS) rate was 64% (range, 6.5–67 months) at 2 years. OS was significantly shorter for patients who presented in the first decade of life (P = .04). The time to progression was prolonged significantly for patients who had no evidence of tumor enhancement on imaging studies (P = .03). When survival data from patients reported in the literature were combined with the CHOP cohort, treatment prolonged OS significantly (P = .003).CONCLUSIONS.The outcome of pediatric patients with GC was extremely poor; however, the current results indicated that treatment may prolong OS. Age < 10 years and contrast enhancement on magnetic resonance imaging studies at diagnosis may be risk factors for shorter survival in pediatric patients with GC. Cancer 2006. © 2006 American Cancer Society.

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Gliomatosis of the brain and spinal cord masquerading as infective lesions

Cited by 17 publications

References 10 publications

Gliomatosis Cerebri Involving the Lumbosacral Spinal Cord

Gliomatosis Cerebri Involving the Lumbosacral Spinal Cord

Differenzialdiagnostische Abgrenzung Enzephalitis versus Gliom mittels Magnetresonanzspektroskopie

Gliomatosis cerebri: 20 Years of experience at the Children's Hospital of Philadelphia

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