Gliomatosis Peritonei and Its Relation to Teratoma: Role of Imaging and Histological Aspects

Patel, Tarang; Meena, Virendrakumar

doi:10.7759/cureus.28849

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…Gliomatosis peritonei (GP), more commonly associated with immature teratomas, are nodules see in the omentum or peritoneum and can be mistaken for carcinomatosis. GP is rarely associated with mature teratomas with case reports noted ( Patel and Meena, 2022 Sep 6 ). Presence of GP may be useful to distinguish immature and mature teratomas.…”

Section: Discussionmentioning

confidence: 99%

Management of ruptured ovarian teratoma mimicking advanced ovarian cancer

Jane Chua,

Barr,

Prints

et al. 2024

Gynecologic Oncology Reports

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Section: Discussionmentioning

confidence: 99%

Management of ruptured ovarian teratoma mimicking advanced ovarian cancer

Jane Chua,

Barr,

Prints

et al. 2024

Gynecologic Oncology Reports

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“…Gliomatosis peritonei (GP) is a rare condition of mature glial tissue within the peritoneum often associated with immature teratomas. Implants of benign glial tissue often involve the peritoneum, omentum, or lymph nodes [ 1 ]. Thus far, approximately 100 cases of GP have been reported [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

A Report of a Rare Case of Rapidly Progressing Immature Teratoma With Associated Splenic Metastasis and Gliomatosis Peritonei

Adkoli,

Smith,

Kennedy

et al. 2024

Cureus

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Gliomatosis peritonei (GP) is a rare condition of mature glial tissue within the peritoneum often associated with immature teratomas. This was a case of rapid progression of immature teratoma with splenic lesions and associated GP. The patient was a 21-year-old female who presented with abdominal pain and CT imaging showing suspected malignant teratoma. The patient underwent exploratory laparotomy with fertility-sparing debulking surgery and was diagnosed with stage IIIC grade 3 immature teratoma. She then received adjuvant chemotherapy with bleomycin, etoposide, and cisplatin. Surveillance imaging demonstrated a non-avid splenic lesion. The tumor markers remained normal. She underwent robotic splenectomy and partial peritonectomy with intra-operative findings revealing numerous peritoneal nodules. Follow-up surveillance imaging showed no further lesions. The final histopathology examination demonstrated mature and mesenchymal neural tissue consistent with residual teratoma and no immature elements. The specimens were largely composed of nodules of mature glial tissue and focal areas of mature neuronal tissue. Immunohistochemistry demonstrated glial fibrillary acidic protein (GFAP) and S100 expression, confirming neural origin tissue. Octamer-binding transcription factor 4 (OCT-4) immunostain was negative which confirmed the absence of immature neural tissue. We report a rare case of rapid progression of immature teratoma with splenic metastasis and peritoneal nodules found ultimately to be mature teratoma and associated GP. Recognition of rapidly growing teratoma with new lesions as potential GP is imperative to prevent misdiagnosis as recurrence or progression of disease. This case was treated with secondary debulking surgery which should be a consideration of management if surgically feasible.

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“…Due to its rarity, MCOT with GP poses a diagnostic challenge as it may easily be mistaken for a malignant ovarian mass such as a germ cell tumour, particularly in the paediatric population [ 6 ]. We report a rare case of a giant mature ovarian teratoma accompanied by GP, massive ascites, pleural effusion, and splenunculus in a 12-year-old female patient.…”

Section: Introductionmentioning

confidence: 99%

Ovarian Teratoma Presenting With Gliomatosis Peritonei and a Melange of Symptoms Mimicking Ovarian Cancer in a Paediatric Patient

Bahall,

De Barry,

Sookdeo

et al. 2023

Cureus

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Gliomatosis peritonei (GP) is a rare condition characterised by mature glial nodules that implant in the peritoneum, lymph nodes, or omentum. GP is typically associated with mature or immature ovarian teratomas and usually affects adolescent females. Although neuroglia may be a standard feature of mature ovarian teratomas, widespread peritoneal glial nodules, ascites, and pleural effusion are rare, particularly in the paediatric population. We report a case of a giant left mature ovarian teratoma associated with GP and omental splenunculus in a 12-year-old female who presented with constipation, an adnexal mass, ascites, pleural effusion, and elevated CA-125 levels. The patient successfully underwent fertility-sparing surgery in the form of a left salpingo-oophorectomy, omentectomy, and resection of peritoneal glial deposits. In light of the current scarcity of data on this clinical entity in the literature, we hope to raise awareness of this rare presentation of mature ovarian teratoma, the challenges associated with preoperative diagnosis, and the impact of fertility-sparing surgery on potential oncological and reproductive outcomes in a paediatric patient.

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Gliomatosis Peritonei and Its Relation to Teratoma: Role of Imaging and Histological Aspects

Cited by 5 publications

References 17 publications

Management of ruptured ovarian teratoma mimicking advanced ovarian cancer

Management of ruptured ovarian teratoma mimicking advanced ovarian cancer

A Report of a Rare Case of Rapidly Progressing Immature Teratoma With Associated Splenic Metastasis and Gliomatosis Peritonei

Ovarian Teratoma Presenting With Gliomatosis Peritonei and a Melange of Symptoms Mimicking Ovarian Cancer in a Paediatric Patient

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