Gliomatous Transformation and Demyelinating Diseases

Anderson, Milne; Hughes, Brodie; Jefferson, Michael; Smith, William Thomas Lingwood; Waterhouse, J. A. H.

doi:10.1093/brain/103.3.603

Cited by 24 publications

(18 citation statements)

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“…Previous studies have focused on the possible associations between MS and CNS tumours, 16,18 bladder cancers, 16 cancers of the haematopoitic and lymphatic system, 12-14 breast cancers 15,16 and nasopharyngeal cancers. 16 In our study, the observed number of CNS tumours, bladder cancers and haematopoietic-lymphatic malignancies did not exceed the expected.…”

Section: Discussionmentioning

confidence: 99%

“…Ratios of the incidence of breast cancer in women with MS to that in women without MS served as measure of the relative risk (RR). Analyses were carried out using the proc GENMOD procedure in SAS, and adjustment was made for age (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) , . .…”

Section: Registersmentioning

confidence: 99%

“…[12][13][14] Overall, MS patients do not seem to be at an increased risk of developing neither cancer in general, nor Hodgkin lymphoma in particular, [15][16][17] but increased risks of breast cancer, 15,16 cancers of the CNS, 16,18 the urinary tract system 16 and nasopharynx 16 have been suggested. Typically such observations have been based on a small number of cases, rendering the risk estimates statistically imprecise.…”

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confidence: 99%

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Cancer risk among patients with multiple sclerosis: A population‐based register study

Nielsen

Rostgaard

Rasmussen

et al. 2005

Intl Journal of Cancer

124

144

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Cancer occurrence in patients with multiple sclerosis (MS) has been little studied, but associations with brain tumours, breast cancer, Hodgkin lymphoma and nasopharyngeal carcinoma have been suggested. We took advantage of population-based registers of MS and cancer to assess the risk of cancer following diagnosis of MS. Patients registered in the Danish Multiple Sclerosis Register were linked with the Danish Cancer Register to obtain information on cancer occurrence. The ratio of the observed to the number of expected cancers based on population-based incidence rates, i.e., the standardised incidence ratio (SIR), served as measure of the relative cancer risk. A database comprising all Danish women born after April 1, 1935, with information on all live-born children, was used in the analyses of breast cancer to adjust for reproductive factors.

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Section: Discussionmentioning

confidence: 99%

Section: Registersmentioning

confidence: 99%

mentioning

confidence: 99%

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Cancer risk among patients with multiple sclerosis: A population‐based register study

Nielsen

Rostgaard

Rasmussen

et al. 2005

Intl Journal of Cancer

124

144

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“…Opinion is divided about whether the rare concurrence of multiple sclerosis and glioma is explained by cause and effect or coincidence 15,23 . If gliomas in patients with multiple sclerosis are more likely to be multicentric, then the hypothesis of cause and effect could be supported.…”

Section: Discussionmentioning

confidence: 99%

Glioma and multiple sclerosis: case report

Werneck

Scola

Arruda

et al. 2002

Arq. Neuro-Psiquiatr.

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-We report a case of a 44-years-old woman with relapsing-remitting and secondarily progressive form of multiple sclerosis (MS) since aged 24 years, who developed an anaplastic astrocytoma. The neurological manifestations of the tumor were misinterpreted as resulting from MS. Sequential MRI examination and seizures raised the possibility of another nature of her symptoms, besides MS. Her initial good response to high doses corticosteroids led to the initial assumption her symptoms were only exclusively due to the demyelinating process. She underwent craniotomy with radical excision of the lesion. Pathological examination disclosed anaplastic astrocytoma. Other cases of coincidental MS and primary CNS tumors are reviewed, as well as their possible relation.KEY WORDS: multiple sclerosis, anaplastic astrocytoma, cerebral neoplasm.Glioma e esclerose múltipla: relato de caso Glioma e esclerose múltipla: relato de caso Glioma e esclerose múltipla: relato de caso Glioma e esclerose múltipla: relato de caso Glioma e esclerose múltipla: relato de caso RESUMO -Relatamos o caso de uma paciente de 44 anos, portadora de esclerose múltipla forma surtoremissão e progressiva secundária, que na evolução desenvolveu um astrocitoma anaplásico. Os sintomas do tumor se confundiram com os da esclerose múltipla e com a repetição de ressonâncias magnéticas foi possível suspeitar do diagnóstico. Além dos sinais neurológicos, também apresentava crises convulsivas. A melhora com os cursos de pulsoterapia mascaravam os sintomas do tumor. Submetida a craniotomia e retirado tumor com características histológicas e histoquímicas de astrocitoma anaplásico, ao lado de áreas de desmielinização típicas de esclerose múltipla. São discutidos os aspectos radiológicos, incidência e mecanismos da concomitância das duas doenças. PALAVRAS-CHAVE: esclerose múltipla, astrocitoma anaplásico, tumor cerebral.

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“…Several reports on the co-existence of multiple sclero sis and glioma have been published [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21], Usually, the demyelinating disorder has been the presenting illness, and the glioma developed after intervals from 16 months to 28 years. MS has, however, in most cases run a benign course.…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma Associated with Multiple Sclerosis: Coincidence or Induction?

Aarli

Mørk²,

Myrseth³

et al. 1989

Eur Neurol

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A 63-year-old man died of a brain tumor 29 years after onset of multiple sclerosis (MS). The MS diagnosis was based upon clinical evidence of two brain stem lesions, separate in time, retinal periphlebitis, a fluctuating course of the disease, and supported by the observation of definite cognitive impairment at the age of 41 years, and an increased number of lymphocytes in the cerebrospinal fluid which normalized during gradual recovery. The MS diagnosis was confirmed at autopsy, which also revealed a glioblastoma developing adjacent to typical MS plaques.

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Gliomatous Transformation and Demyelinating Diseases

Abstract: The clinical and pathological details are described of three patients with demyelinating diseases associated with a glioma, the effects of which proved fatal. The findings suggest that the tumours developed from neoplastic transformation of glia in areas of established demyelination.

Cited by 24 publications

References 0 publications

Cancer risk among patients with multiple sclerosis: A population‐based register study

Cancer risk among patients with multiple sclerosis: A population‐based register study

Glioma and multiple sclerosis: case report

Glioblastoma Associated with Multiple Sclerosis: Coincidence or Induction?

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