Glioneuronal tumors of cerebral hemisphere in children: correlation of surgical resection with seizure outcomes and tumor recurrences

Abstract

Lesionectomy alone often provides a high-rate seizure freedom. GGs and DNTs are benign tumor, but recurrences of GGs and DNTs are not uncommon. They may show late recurrences in spite of GTR. These patients need longer follow-up for 10 years. Recurrent seizures are often related to a tumor recurrence.

Epilepsy surgery of “low grade epilepsy associated neuroepithelial tumors”: A retrospective nationwide Italian study

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] For this group of tumors the acronym "LEATs" (longterm epilepsy associated tumors) was proposed by Luyken et al 1 By definition, "long term" means causing drug-resistant seizures for 2 years or more. [1][2][3][4][5][6][7][8][9][10][11][12][13] For this group of tumors the acronym "LEATs" (longterm epilepsy associated tumors) was proposed by Luyken et al 1 By definition, "long term" means causing drug-resistant seizures for 2 years or more.…”

“…18 If uncontrolled, tumor-related epilepsy significantly affects patients' quality of life, causes cognitive deterioration, and may result in significant morbidity. 2,[9][10][11]13,20 Currently, the definition of drugresistance applies to "failure of adequate trials of two tolerated and appropriately chosen and used AED schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom," 21 and it may be difficult to assess this criterion in <2 years. 2,[9][10][11]13,20 Currently, the definition of drugresistance applies to "failure of adequate trials of two tolerated and appropriately chosen and used AED schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom," 21 and it may be difficult to assess this criterion in <2 years.…”

“…On the other hand, assessment of drug responsiveness may necessitate at least 1 year of observation. 6,7,12,[14][15][16][17][18]23 In fact, although LEATs are usually considered to have a benign indolent behavior, several reports have demonstrated that gangliogliomas (GGs) 3,9,13 and some glial tumors, such as pleomorphic xanthoastrocytoma (PXA), 3,24 may exhibit an evolving course or malignant transformation. 22 Furthermore, in the field of LEATs, where a correct histologic and molecular diagnosis is increasingly important, avoiding loss of time is essential, for epileptologic, neuropsychological, and oncologic reasons.…”

“…1,[4][5][6]12,13,16,17,25 LEATs are represented primarily by classic GNTs, that is, GGs and dysembryoplastic neuroepithelial tumors (DNETs), and are most commonly observed in a mesiotemporal location. 1,[4][5][6]12,13,16,17,25 LEATs are represented primarily by classic GNTs, that is, GGs and dysembryoplastic neuroepithelial tumors (DNETs), and are most commonly observed in a mesiotemporal location.…”

“…32 Characterizing molecular signatures could be very helpful, allowing a more precise histologic definition and a better comprehension of both oncologic behavior 3,14,15,18,23,29,30,33 and the epileptologic mechanisms involved. 3,5,6,10,13,16,23,25 However, extremely wide and hardly explicable variable percentages of association of LEATs and FCD, ranging from 0 to 80%, 3,5,6,10,13,16,23,25 have been reported so far. 3,5,6,10,13,16,23,25 However, extremely wide and hardly explicable variable percentages of association of LEATs and FCD, ranging from 0 to 80%, 3,5,6,10,13,16,23,25 have been reported so far.…”