Gliosarcoma with osteosarcomatous differentiation: review of radiological and pathological features

Alatakis, Steven; Stuckey, Steven; Siu, Kevin; McLean, Catriona

doi:10.1016/j.jocn.2003.08.009

Cited by 30 publications

(33 citation statements)

References 47 publications

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“…Other brain and spinal gliosarcoma cases usually had a medical history of radiation therapy for other cerebellar tumors. Quite a number of gliosarcomas have been reported as secondary tumors after radiation therapy for histologically different primary CNS tumors (5-9). Among several possible mechanisms for gliosarcoma histogenesis, the transformation theory, which states that part of a glial tumor is dedifferentiated to primitive cells and transformed into sarcomatous components, supports the idea that radiation therapy might induce a dedifferentiation of the glial cell to the sarcomatous cells in cases with previous CNS tumors (4, 6, 8, 10, 11).…”

Section: Discussionmentioning

confidence: 99%

Gliosarcoma of the Cerebellar Hemisphere: a Case Report and Review of the Literature

et al. 2010

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Gliosarcoma is a rare central nervous system tumor usually located in the supratentorial area. Here we report a rare case of a gliosarcoma that developed in the cerebellar hemisphere in a 70-year-old woman. Computed tomography (CT) and magnetic resonance imaging (MRI) of the brain revealed an infratentorial mass of which radiological features were similar to those of glioblastoma. The tumor was diagnosed by pathology as a gliosarcoma. Though rare, gliosarcoma should be considered in the differential diagnosis of infratentorial tumors with radiological features of glioblastoma or metastasis in elderly patients.

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Section: Discussionmentioning

confidence: 99%

Gliosarcoma of the Cerebellar Hemisphere: a Case Report and Review of the Literature

et al. 2010

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“…Epithelial differentiation with carcinomatous features can also occur in glial portions [115]. The sarcomatous component of this tumour shows atypical, aggressive features and can differentiate along multiple distinct lineages, such as fibroblastic, osteogenic, chondrogenic, adipogenic, and myogenic types, especially upon exposure to radiation treatment [2,7,8,10,52,89,139]. A similar potential variant termed gliofibroma has also been described consisting of biphasic glial and non-sarcomatous fibroblastic components commonly found in paediatric patients [89].…”

Section: Gliosarcomamentioning

confidence: 99%

Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features

Karsy¹,

Gelbman²,

Shah³

et al. 2012

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A b s t r a c t Since the recent publication of the World Health Organization brain tumour classification guidelines in 2007, a significant expansion in the molecular understanding of glioblastoma multiforme (GBM) and its pathological as well as genomic variants has been evident. The purpose of this review article is to evaluate the histopathological, molecular and clinical features surrounding emerging and currently established GBM variants. The tumours discussed include classic glioblastoma multiforme and its four genomic variants, proneural, neural, mesenchymal, classical, as well as gliosarcoma (GS), and giant cell GBM (gcGBM). Furthermore, the emerging variants include fibrillary/epithelial GBM, small cell astrocytoma (SCA), GBM with oligodendroglial component (GBMO), GBM with primitive neuroectodermal features (GBM-PNET), gemistocytic astrocytoma (GA), granular cell astrocytoma (GCA), and paediatric high-grade glioma (HGG) as well as diffuse intrinsic pontine glioma (DIPG

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“…[1728] The sarcomatous areas commonly resemble fibrosarcoma, but may show a variety of lines of mesenchymal differentiation, such as osteogenic, chondrogenic, adipogenic, smooth, and skeletal muscle. [224] The occurrence of similar genetic alterations in both glial and mesenchymal components supports the concept of a monoclonal origin of the metaplastic mesenchymal differentiation from the astrocytic component. [11122829] However, the molecular mechanisms governing this mesenchymal differentiation are still unclear.…”

Section: Introductionmentioning

confidence: 63%

Analysis of a synchronous gliosarcoma and meningioma with long survival: A case report and review of the literature

Linhares¹,

Martinho²,

Carvalho³

et al. 2013

Surg Neurol Int

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Background:The simultaneous occurrence of multiple intracranial neoplasms has been reported, especially in genetic familial syndromes and after cranial irradiation. In the absence of these etiologic factors, some reports showed simultaneous occurrence of glioblastoma and meningioma but the association between gliosarcoma and meningioma is unknown.Case Description:We report a case of a 51-year-old woman with synchronous gliosarcoma and meningioma in whom extensive immunohistochemical characterization and molecular profile was performed. The gliosarcoma recurred 21 months after the first resection, reaching 3 years of overall survival. A molecular characterization of all three lesions was performed. None of the lesions showed the presence of mutations in TP53 and BRAF genes. MGMT analysis showed the presence of loss of expression associated with promoter hypermethylation in both gliosarcoma lesions. EGFR overexpression and gene amplification was found only in the recurrent gliosarcoma.Conclusion:The immunohistochemistry and molecular data of this unique case, suggest the distinct clonal origin of meningioma and gliosarcoma lesions, and the association of MGMT methylation with the presumable favorable prognosis observed.

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Gliosarcoma with osteosarcomatous differentiation: review of radiological and pathological features

Cited by 30 publications

References 47 publications

Gliosarcoma of the Cerebellar Hemisphere: a Case Report and Review of the Literature

Gliosarcoma of the Cerebellar Hemisphere: a Case Report and Review of the Literature

Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features

Analysis of a synchronous gliosarcoma and meningioma with long survival: A case report and review of the literature

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