Family farming is a lifestyle and agricultural base that has ensured food for the world’s growing population in addition to the family’s own subsistence. However, the intensification of production processes to primarily generate exportable surpluses is based on the constant input of industrial inputs of low local socioeconomic viability. This study aims to evaluate the sustainability of family farms and their impact on the adoption of homeopathy instead of traditional/conventional intensification techniques. The study was conducted at six family farms located in the Serrana Mesoregion, Santa Catarina, Brazil, and include farms were classified according to the management and representativeness of their agricultural activity, i.e., conventional grains-cattle, milk-grains, grains and diversified, and according to their ecological basis, i.e., agroecological and organic. To discuss the sustainability of the family farms that were evaluated, the of metrics emergy synthesis, ecotoxicity potential and socioeconomic indicators are used. The results indicate that conventional diversified property has the best overall performance with regard to sustainability, including emergy yield ratio (EYR 1.88), emergy investment ratio (EIR 1.13), return on assets (1.22), hourly income of work (36.6 BRL/h) and income sufficiency (3.3). Agroecological and organic properties have better performance in renewability (76% and 75%), environmental load (ELR = 0.32 and 0.34), sustainability (ESI = 4.78 and 3.5) and potential ecotoxicity (1.736 and 1.579 kg 1.4 DCB-eq/ha). The contribution of homeopathy in an alternative scenario results in a 19% reduction in nonrenewable flows in conventional management properties and a decrease of up to 91% in ecotoxicity in grain + cattle properties. Using homeopathy, the return on assets and profit margin can be increased by up to 43% and income per hour of work and income sufficiency can be increased by 20% and 16%, respectively. This study contributes to discussions about the importance of using homeopathic therapies as a viable strategy that can be used in strategic public policy plans to improve the sustainability of family farms.