Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly

Danpanichkul, Pojsakorn; Suparan, Kanokphong; Ng, Cheng Han; Dejvajara, Disatorn; Kongarin, Siwanart; Panpradist, Nuttada; Chaiyakunapruk, Nathorn; Muthiah, Mark D.; Chen, Vincent L.; Huang, Daniel Q.; Díaz, Luis Antonio; Noureddin, Mazen; Arab, Juan Pablo; Wijarnpreecha, Karn

doi:10.1016/j.jhepr.2024.101020

Cited by 8 publications

(1 citation statement)

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“…The sequelae of alcohol misuse manifest predominantly as severe liver disease, notably cirrhosis, alcohol-associated hepatitis, and liver cancer. [5][6][7][8] Beyond its impact on the liver, alcohol consumption is also closely linked to various cardiovascular complications and psychiatric conditions such as alcohol-induced cardiomyopathy (ACM) and alcohol use disorder (AUD), respectively. 3,9,10 Considering the significant impact of addiction, cardiovascular, and liver complications resulting from alcohol consumption, this study was conducted to examine the worldwide and regional burdens of AUD, alcohol-associated liver disease (ALD), and cardiovascular issues linked to alcohol use spanning the years 2010-2019.…”

Section: Introductionmentioning

confidence: 99%

Socio‐economic association of alcohol use disorder and cardiovascular and alcohol‐associated liver disease from 2010 to 2019

Danpanichkul,

Chen,

Chaiyakunapruk

et al. 2024

Aliment Pharmacol Ther

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SummaryBackgrounds and AimsAlcohol use leads to disabilities and deaths worldwide. It not only harms the liver but also causes alcohol use disorder (AUD) and heart disease. Additionally, alcohol consumption contributes to health disparities among different socio‐economic groups.MethodsWe estimated global and regional trends in the burden of AUD, liver disease, and cardiovascular disease from alcohol using the methodology of the Global Burden of Disease study.ResultsIn 2019, the highest disability‐adjusted life years rate per 100,000 population was due to AUD (207.31 [95% Uncertainty interval (UI) 163.71–261.66]), followed by alcohol‐associated liver disease (ALD) (133.31 [95% UI 112.68–156.17]). The prevalence rate decreased for AUD (APC [annual percentage change] −0.38%) and alcohol‐induced cardiomyopathy (APC −1.85%) but increased for ALD (APC 0.44%) and liver cancer (APC 0.53%). Although the mortality rate for liver cancer from alcohol increased (APC 0.30%), mortality rates from other diseases decreased. Between 2010 and 2019, the burden of alcohol‐associated complications increased in countries with low and low‐middle sociodemographic index (SDI), contributing more significantly to the global burden.ConclusionThe global burden of AUD, liver, and cardiovascular disease has been high and increasing over the past decade, particularly for liver complications. Lower SDI countries are contributing more to this global burden. There is a pressing need for effective strategies to address this escalating burden.

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