Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

Lozano, Rafael; Naghavi, Mohsen; Foreman, Kyle J; Lim, Stephen S; Shibuya, Kenji; Aboyans, Victor; Abraham, Jerry; Adair, Tim; Aggarwal, Rakesh; Ahn, Stephanie Y.; AlMazroa, Mohammad A.; Alvarado, Miriam; Anderson, Hugh; Anderson, Laurie; Andrews, Kathryn; Atkinson, Charles; Baddour, Larry M.; Barker‐Collo, Suzanne; Bartels, David; Bell, Michelle L.; Benjamin, Emelia J.; Bennett, Derrick; Bhalla, Kavi; Bikbov, Boris; Abdulhak, Aref Bin; Birbeck, Gretchen L.; Blyth, Fiona; Bolliger, Ian; Boufous, Soufiane; Bucello, Chiara; Burch, Michael; Burney, Peter; Carapetis, Jonathan R.; Chen, Honglei; Chou, David; Chugh, Sumeet S.; Coffeng, Luc E.; Colan, Steven D.; Colquhoun, Samantha; Colson, K. Ellicott; Condon, John R.; Connor, Myles; Cooper, Leslie T.; Corriere, Matthew A.; Cortinovis, Monica; Vaccaro, Karen Courville De; Couser, William G.; Cowie, Benjamin C; Criqui, Michael H.; Cross, Marita; Dabhadkar, Kaustubh; Dahodwala, Nabila; Leo, Diego De; Degenhardt, Louisa; Delossantos, Allyne; Denenberg, Julie O.; Jarlais, Don C. Des; Dharmaratne, Samath D; Dorsey, E. Ray; Driscoll, Tim; Duber, Herbert C.; Ebel, Beth E.; Erwin, Patricia J.; Espindola, Patricia; Ezzati, Majid; Feigin, Valery L.; Flaxman, Abraham D.; Forouzanfar, Mohammad H.; Fowkes, F. G. R.; Franklin, Richard C.; Fransen, Marlene; Freeman, Michael K.; Gabriel, Sherine E.; Gakidou, Emmanuela; Gaspari, Flavio; Gillum, Richard F.; González-Medina, Diego; Halasa, Yara A.; Haring, Diana; Harrison, James Edward; Havmoeller, Rasmus; Hay, Roderick J.; Hoën, Bruno; Hotez, Peter J.; Hoy, Damian; Jacobsen, Kathryn H.; James, Spencer L.; Jasrasaria, Rashmi; Jayaraman, Sudha; Johns, Nicole E.; Karthikeyan, Ganesan; Kassebaum, Nicholas J; Keren, Andre; Khoo, Jon Paul; Knowlton, Lisa Marie; Kobusingye, Olive; Koranteng, Adofo; Krishnamurthi, Rita; Lipnick, Michael S; Lipshultz, Steven E.; Ohno, Summer Lockett; Mabweijano, Jacqueline; MacIntyre, Michael F.; Mallinger, Leslie; March, Lyn; Marks, Guy B.; Marks, Robin; Matsumori, Akira; Matzopoulos, Richard; Mayosi, Bongani M.; McAnulty, John H.; McDermott, Mary McGrae; McGrath, John; Memish, Ziad A.; Mensah, George A.; Merriman, Tony R.; Michaud, Catherine; Miller, Matthew; Miller, Ted R.; Mock, Charles; Mocumbi, Ana Olga; Mokdad, Ali H.; Moran, Andrew E.; Mulholland, Kim; Nair, Manisha; Naldi, Luigi; Narayan, K.M. Venkat; Nasseri, Kiumarss; Norman, Paul; O’Donnell, Martin; Omer, Saad B.; Ortblad, Katrina F; Osborne, Richard H.; Ozgediz, Doruk; Pahari, Bishnu; Pandian, Jeyaraj Durai; Rivero, Andrea; Padilla, Rogelio Pérez; Pérez-Ruiz, Fernando; Perico, Norberto; Phillips, David; Pierce, Kelsey; Pope, C. Arden; Porrini, Esteban; Pourmalek, Farshad; Raju, Murugesan; Ranganathan, Dharani; Rehm, Jürgen; Rein, David B.; Remuzzi, Giuseppe; Rivara, Frederick P.; Roberts, Thomas J.; León, Felipe Rodríguez De; Rosenfeld, Lisa C.; Rushton, Lesley; Sacco, Ralph L.; Salomon, Joshua A.; Sampson, Uchechukwu K.A.; Sanman, Ella; Schwebel, David C.; Seguí-Gómez, María; Shepard, Donald S.; Singh, David; Singleton, Jessica; Sliwa, Karen; Smith, Emma; Steer, Andrew C.; Taylor, Jennifer A.; Thomas, Bernadette; Tleyjeh, Imad M.; Towbin, Jeffrey A.; Truelsen, Thomas; Undurraga, Eduardo A.; Venketasubramanian, Narayanaswamy; Vijayakumar, Lakshmi; Vos, Theo; Wagner, Gregory R.; Wang, Mengru; Wang, Wenzhi; Watt, Kerrianne; Weinstock, Martin A.; Weintraub, Robert G.; Wilkinson, James D.; Woolf, Anthony D.; Wulf, Sarah; Yeh, Pon Hsiu; Yip, Paul; Zabetian, Azadeh; Zheng, Zhi; Lopez, Alan D; Murray, Christopher J L

doi:10.1016/s0140-6736(12)61728-0

Cited by 12,132 publications

(8,887 citation statements)

References 79 publications

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“…Influenza is among the leading causes of hospitalizations and deaths 2. Our results suggest that, each year, a substantial number of persons in Central America are hospitalized and died as a result of influenza.…”

Section: Resultsmentioning

confidence: 63%

Estimating the burden of influenza‐associated hospitalizations and deaths in Central America

Descalzo

Clara²,

Guzman

et al. 2016

Influenza Resp Viruses

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ObjectivesOur objective was to estimate the incidence of influenza‐associated hospitalizations and in‐hospital deaths in Central American Region.Design and settingWe used hospital discharge records, influenza surveillance virology data, and population projections collected from Costa Rica, El Salvador, Guatemala, Honduras, and Nicaragua to estimate influenza‐associated hospitalizations and in‐hospital deaths. We performed a meta‐analysis of influenza‐associated hospitalizations and in‐hospital deaths.Main outcome measuresThe highest annual incidence was observed among children aged <5 years (136 influenza‐associated hospitalizations per 100 000 persons).ResultsAnnually, 7 625–11 289 influenza‐associated hospitalizations and 352–594 deaths occurred in the subregion.ConclusionsOur results suggest that a substantive number of persons are annually hospitalized because of influenza. Health officials should estimate how many illnesses could be averted through increased influenza vaccination.

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Section: Resultsmentioning

confidence: 63%

Estimating the burden of influenza‐associated hospitalizations and deaths in Central America

Descalzo

Clara²,

Guzman

et al. 2016

Influenza Resp Viruses

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show abstract

“…The adjustment of data during the estimation process, which involves a multi-step process by which data quality is ‘assessed and enhanced’, is difficult to replicate even by other skilled and well-resourced technicians, making it hard to understand how the adjustments have affected the initial data inputs [37]. It is the extent of adjustment of the country data inputs that is most often a source of concern among users, particularly those at country level who are faced with the challenge of explaining the different figures to policy makers.…”

Section: The Supply Side: a Booming Businessmentioning

confidence: 99%

Global estimates of country health indicators: useful, unnecessary, inevitable?

AbouZahr¹,

Boerma

Hogan

2017

Global Health Action

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Background: The MDG era relied on global health estimates to fill data gaps and ensure temporal and cross-country comparability in reporting progress. Monitoring the Sustainable Development Goals will present new challenges, requiring enhanced capacities to generate, analyse, interpret and use country produced data. Objective: To summarize the development of global health estimates and discuss their utility and limitations from global and country perspectives. Design: Descriptive paper based on findings of intercountry workshops, reviews of literatureon and synthesis of experiences. Results: Producers of global health estimates focus on the technical soundness of estimation methods and comparability of the results across countries and over time. By contrast, country users are more concerned about the extent of their involvement in the estimation process and hesitate to buy into estimates derived using methods their technical staff cannot explain and that differ from national data sources. Quantitative summaries of uncertainty may be of limited practical use in policy discussions where decisions need to be made about what to do next. Conclusions: Greater transparency and involvement of country partners in the development of global estimates will help improve ownership, strengthen country capacities for data production and use, and reduce reliance on externally produced estimates.

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“…However, infectious diseases still caused approximately 20% of deaths in 2010 (Lozano et al , 2012) and remain as a medical challenge to physicians and health organizations. The emergence and re‐emergence of infections caused by HIV, Ebola virus and Zika virus has put great pressure on the development of vaccines and new specific therapeutics.…”

Section: Introductionmentioning

confidence: 99%

Drug repurposing screens and synergistic drug‐combinations for infectious diseases

Zheng

Sun

Simeonov

2017

British J Pharmacology

221

200

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Infectious diseases account for nearly one fifth of the worldwide death toll every year. The continuous increase of drug‐resistant pathogens is a big challenge for treatment of infectious diseases. In addition, outbreaks of infections and new pathogens are potential threats to public health. Lack of effective treatments for drug‐resistant bacteria and recent outbreaks of Ebola and Zika viral infections have become a global public health concern. The number of newly approved antibiotics has decreased significantly in the last two decades compared with previous decades. In parallel with this, is an increase in the number of drug‐resistant bacteria. For these threats and challenges to be countered, new strategies and technology platforms are critically needed. Drug repurposing has emerged as an alternative approach for rapid identification of effective therapeutics to treat the infectious diseases. For treatment of severe infections, synergistic drug combinations using approved drugs identified from drug repurposing screens is a useful option which may overcome the problem of weak activity of individual drugs. Collaborative efforts including government, academic researchers and private drug industry can facilitate the translational research to produce more effective new therapeutic agents such as narrow spectrum antibiotics against drug‐resistant bacteria for these global challenges.Linked ArticlesThis article is part of a themed section on Inventing New Therapies Without Reinventing the Wheel: The Power of Drug Repurposing. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.2/issuetoc

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Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

Abstract: Bill & Melinda Gates Foundation.

Cited by 12,132 publications

References 79 publications

Estimating the burden of influenza‐associated hospitalizations and deaths in Central America

Estimating the burden of influenza‐associated hospitalizations and deaths in Central America

Global estimates of country health indicators: useful, unnecessary, inevitable?

Drug repurposing screens and synergistic drug‐combinations for infectious diseases

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