Global and selective detection of organohalogens in environmental samples by comprehensive two-dimensional gas chromatography–tandem mass spectrometry and high-resolution time-of-flight mass spectrometry

Implementation of comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry for the simultaneous determination of halogenated contaminants and polycyclic aromatic hydrocarbons in fish

“…Currently, MS is the dominating detection technique in GC analysis of PAHs providing, thanks to its selectivity, more accurate results compared with GC-FID [11,15]. Simultaneous determination of a wide range of contaminants using 1D-GC-MS is often not possible, since a number of co-elutions and partial co-elutions among analytes and matrix components occur, especially when congeners and/or isomers with similar mass spectra, and thus the same quantification masses (m/z), had to be distinguished [5,[16][17][18][19].…”

“…Since the number of environmental contaminants which undergo the legislative control or are included in the monitoring programs of the European Food Safety Authority [1] and other international bodies (e.g., World Health Organization [2], US Environmental Protection Agency [3], and US Food and Drug Administration [4]) continuously increases, the demand for high-throughput, selective, sensitive, and non-expensive analytical methods is arising as well [5]. In response to the above-mentioned aspects, the European project CONffIDENCE [6] was established to support respective food safety issues through the development and validation of simple, inexpensive, and rapid screening tools, which enable detection of selected food and environmental pollutants.…”

Application of two-dimensional chromatography in the analysis of Chinese herbal medicines

“…To date, 2D chromatographic systems have been used successfully in the analysis of petroleum samples [1], environmental samples [2], food samples [3] and some other complex mixtures encountered in the biotechnology and life sciences. In recent years, with the requirements of completely profiling complex samples and tracking potentially bioactive components in CHMs, many researchers have paid special attention to the analysis of CHMs by combining two effective separation modes, such as 2D-GC, 2D-LC and LC-CEC.…”

Recent Applications of Comprehensive Two-Dimensional Gas Chromatography to Environmental Matrices

“…Halogenated compounds were successfully detected (Hashimoto et al, 2011) from several kinds of environmental samples by using a GC×GC chromatograph coupled with a tandem mass spectrometer (GC×GC-MS/MS). The global and selective detection of halogenated compounds was achieved by neutral loss scans of chlorine, bromine and/or fluorine using an MS/MS which was especially effective for compounds with more than two halogen substituents (Figure 8).…”

“…In the future, the authors expect to achieve the complete global detection of any compound in one measurement of a crude sample simply with a GC×GC-HRTOFMS if it becomes possible to extract the desired information from the GC×GC-HR TOFMS data. (Hashimoto et al, 2011). Copyright (2011, with permission from Elsevier.…”