Global Breast Cancer: The Lessons to Bring Home

Formenti, Silvia C.; Arslan, Alan A.; Love, Susan M.

doi:10.1155/2012/249501

Cited by 24 publications

(21 citation statements)

References 44 publications

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“…This finding must be strongly considered in thinking about any future strategies directed to this disease and the "late" presentation problem in Bangladesh. It certainly reinforces arguments made about the inapplicability of screening strategies from high incidence-high-income countries to countries with low incidence like Bangladesh (Formenti et al, 2012). Finally, our data support the feasibility of using a motivational video and importantly navigation whereby a community health worker accompanies a woman with a suspected serious breast problem, to a specialty health care facility, can get women into care.…”

Section: Discussionsupporting

confidence: 82%

Feasibility Study of Case-Finding for Breast Cancer by Community Health Workers in Rural Bangladesh

Chowdhury¹,

Love²,

Chowdhury³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Mortality from breast cancer is high in low-and middle-income countries, in part because most patients have advanced stage disease when first diagnosed. Case-finding may be one approach to changing this situation. Materials and Methods: We conducted a pilot study to explore the feasibility of population-based case finding for breast cancer by community health workers (CHWs) using different data collection methods and approaches to management of women found to have breast abnormalities. After training 8 CHWs in breast problem recognition, manual paper data collection and operation of a cell-phone software platform for reporting demographic, history and physical finding information, these CHWs visited 3150 women >age 18 and over they could find--from 2356 households in 8 villages in rural Bangladesh. By 4 random assignments of villages, data were collected manually (Group 1), or with the cell-phone program alone (Group 2) or with management algorithms (Groups 3 and 4), and women adjudged to have a serious breast problem were shown a motivational video (Group 3), or navigated/accompanied to a breast problem center for evaluation (Group 4). Results: Only three visited women refused evaluation. The manual data acquisition group (1) had missing data in 80% of cases, and took an average of 5 minutes longer to acquire, versus no missing data in the cell phone-reporting groups (2,3 and 4). One woman was identified with stage III breast cancer, and was appropriately treated. Conclusions: Among very poor rural Bangladeshi women, there was very limited reluctance to undergo breast evaluation. The estimated rarity of clinical breast cancer is supported by these population-based findings. The feasibility and efficient use of mobile technology in this setting is supported. Successor studies may most appropriately be trials focusing on improving the suggested benefits of motivation and navigation, on increasing the numbers of cases found, and on stage of disease at diagnosis as the primary endpoint.

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Section: Discussionsupporting

confidence: 82%

Feasibility Study of Case-Finding for Breast Cancer by Community Health Workers in Rural Bangladesh

Chowdhury¹,

Love²,

Chowdhury³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Breast cancer is a molecularly heterogeneous disease and the most common cancer affecting women all worldwide [29] . A previous study demonstrated that autophagy regulation has different and even opposite effects in breast cancer, indicating the need for a selection strategy when aiming to modulate autophagy in cancer therapy [30] .…”

Section: Discussionmentioning

confidence: 99%

Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer

Wang

et al. 2018

Cell Physiol Biochem

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Background/Aims: An increasing body of evidence shows that long noncoding RNAs (lncRNAs) are involved in many different cancers. In this study, we aimed to investigate the competing endogenous RNA (ceRNA)-dependent mechanism by which the lncRNA GAS5 contributes to the development of breast cancer. Methods: A total of 68 breast cancer patients were enrolled, and breast cancer and adjacent normal tissues were collected. The human breast cancer cell lines MDA-MB-231, MDA-MB-453, BT549, SK-BR-3 and MCF-7 and human breast cell line MCF10A were utilized in this study. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting were performed to detect expression of relative factors. RNA immunoprecipitation (RIP) was used to evaluate the relationship between GAS5 and miR-23a, and a dual luciferase reporter gene assay was employed to assess the relationship between ATG3 and miR-23a. A subcutaneous xenograft nude mouse model was generated to examine the role of GAS5 and its regulatory pathway in autophagy. Results: GAS5 levels were frequently decreased in breast cancer tissues and cell lines, and its relatively low expression was closely related to a larger tumour size, advanced tumour-node-metastasis (TNM) stage and estrogen receptor-negative (ER-) breast cancer tissues. More importantly, we found that GAS5 promoted autophagy, with enhanced autophagosome formation after GAS5 overexpression. GAS5 was found to act as a microRNA sponge in a pathway that included miR-23a and its target gene ATG3. The GAS5-miR-23a-ATG3 axis significantly regulated autophagy in vivo and in vitro. Conclusions: In summary, we report that the GAS5-miR-23a-ATG3 axis can be regarded as a key regulator of autophagy pathways in breast cancer; it may constitute a promising biomarker and therapeutic target in the future.

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“…Over-referral represents the central negative issue with mammographic breast screening putting a high financial pressure on healthcare systems [9,10] as well as has great undue psychological impact on the patients [11,12]. Moreover, there is the adverse effect of misdiagnosis of malignant lesions reported as benign (false negatives) [13].…”

Section: Introductionmentioning

confidence: 99%

High sensitivity non‐invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy

Ghiţă

Matousek

Stone

2017

Journal of Biophotonics

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The aim of this research was to develop a novel approach to probe non-invasively the composition of inorganic chemicals buried deep in large volume biological samples. The method is based on advanced Transmission Raman Spectroscopy (TRS) permitting chemical specific detection within a large sampling volume. The approach could be beneficial to chemical identification of the breast calcifications detected during mammographic X-ray procedures. The chemical composition of a breast calcification reflects the pathology of the surrounding tissue, malignant or benign and potentially the grade of malignancy. However, this information is not available from mammography, leading to excisional biopsy and histopathological assessment for a definitive diagnosis. Here we present, for the first time, a design of a new high performance deep Raman instrument and demonstrate its capability to detect type II calcifications (calcium hydroxyapatite) at clinically relevant concentrations and depths of around 40 mm in phantom tissue. This is around double the penetration depth achieved with our previous instrument design and around two orders of magnitude higher than that possible when using conventional Raman spectroscopy.

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Global Breast Cancer: The Lessons to Bring Home

Cited by 24 publications

References 44 publications

Feasibility Study of Case-Finding for Breast Cancer by Community Health Workers in Rural Bangladesh

Feasibility Study of Case-Finding for Breast Cancer by Community Health Workers in Rural Bangladesh

Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer

High sensitivity non‐invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy

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