Global Burden of Head and Neck Cancer

Rahman, Quazi Billur; Iocca, Oreste; Kufta, Kenneth; Shanti, Rabie M.

doi:10.1016/j.coms.2020.04.002

Cited by 45 publications

(34 citation statements)

References 46 publications

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“…Although it still occurs in populations with the presence of known risk factors such as tobacco and alcohol consumption, this is no longer sufficient to explain its higher prevalence in countries such as India, France or Brazil. 45 The prevalence of tobacco and alcohol use in the world as a whole has decreased, especially in men. 42 44 But not so the prevalence of LOCC accompanied by a decrease in the ages of onset and an increase in the prevalence of oral cancer in the youngest population (<45 years) worldwide, particularly in Western populations.…”

Section: Discussionmentioning

confidence: 99%

Effect of Human Development Index and other socioeconomic factors on mortality-to-incidence ratio of lips and oral cavity cancer in Mexican states: an ecological study

et al. 2021

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ObjectivesTo assess the association between the Human Development Index (HDI) and covariates on the mortality-to-incidence ratio (MIR) of lips and oral cavity cancer (LOCC) in Mexico.DesignEcological study.SettingData from 32 Mexican states for year 2019.ParticipantsData set of male and female populations from Mexico.ExposuresSocioeconomic conditions based on HDI and covariates related to healthcare system capacity (total health spending per capita, school dropout and ratio of medical personnel in direct contact with patients).Primary and secondary outcome measuresMIR of LOCC by state and sex was calculated from the Global Burden of Disease Study website for year 2019. Data for calculating HDI 2019 by state and covariates were obtained from the National Institute of Statistics and Geography. A multiple regression model was constructed to measure the effects of HDI and covariates on LOCC-MIR.ResultsAmong the states with the highest HDI (>0.780), Colima had the highest aged-standardised rates per 100.000 in men for incidence (5.026) and mortality (3.118). The greatest burden of the disease was found on men, with the highest Men:Women MIR in Colima (3.10) and Baja California Sur (2.73). The highest MIR (>0.65) was found among the states with the lowest HDI (Oaxaca and Chiapas). For each unit of increase of the HDI there was a decrease in the LOCC- MIR of −0.778, controlling for the covariates. The most suitable regression model explained the 57% (F (p): 0.000) of the variance.ConclusionsMen were most affected by LOCC in Mexican states. The highest MIRs of LOCC were found in the states with the highest HDI. But a worse prognosis of the disease, expressed as a higher MIR, is expected in contexts with lower HDI in the country, even with lower MIRs.

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Section: Discussionmentioning

confidence: 99%

Effect of Human Development Index and other socioeconomic factors on mortality-to-incidence ratio of lips and oral cavity cancer in Mexican states: an ecological study

et al. 2021

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“…Head and neck squamous cell carcinoma (HNSCC), accounts for approximately 80% of head and neck tumors, is highly aggressive with frequent local recurrences and lymph node metastases [ 1 ]. Oral cavity, oropharynx, larynx are the most common sites of HNSCC [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma

Cai

Tan

Huang

et al. 2021

Pathol. Oncol. Res.

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Tomm34, as a member of the outer mitochondrial membrane proteins, is evenly distributed between the cytoplasm and the outer mitochondrial membrane. It is up-regulated in a variety of tumors and correlates with poor prognosis. This study aimed to investigate expression of Tomm34 and its correlations with clinicopathology in oral squamous cell carcinoma (OSCC). Oncomine database and UALCAN database were utilized to predict the expression and prognosis values of Tomm34 in head and neck squamous cell carcinoma (HNSCC). By immunohistochemistry, a retrospective study was performed to verify the bioinformatics results to evaluate the Tomm34 expression and clinicopathological variables in both HPV-positive OSCC and HPV-negative OSCC. Immunohistochemistry of our cohort revealed that 48 cases fulfilled the Tomm34 high expression judgment criteria, and the overall positive rate was 60% (48/80), and 27 cases fulfilled the p16 expression judgment criteria (33.75%, 27/80). The high expression of Tomm34 was closely related with the TNM classification of OSCC (p < 0.01) and tumor size (p < 0.01) both in HPV-negative OSCC and HPV-positive OSCC, while related with lymph node metastasis (p = 0.001) in HPV-negative OSCC and drinking history (p = 0.044) in HPV-positive OSCC. In addition, the Kaplan-Meier curves indicated that higher level of Tomm34 was correlated with poorer overall survival (OS) and disease-free survival (DFS) in HPV-negative OSCC (OS, p = 0.046; DFS, p = 0.020) but not in HPV-positive OSCC (OS, p = 0.824; DFS, p = 0.782). In conclusion, Tomm34 is highly expressed in OSCC and may be a useful factor to provide prognostic information, especially in HPV-negative OSCC group.

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“…Symptoms of hypopharyngeal cancer usually appear late, compared with other HNCs (Rahman et al, 2020). The patients of hypopharyngeal cancer are always diagnosed at a poorer stage and have a poorer prognosis (Cooper et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Hypopharyngeal cancer has the same etiologic factors with laryngeal cancer. The causes contain alcohol, tobacco, chewing areca nut and others (Rahman et al, 2020). But hypopharyngeal cancer has poorer prognoses because of its initially silent development (Rahman et al, 2020).…”

Global Burden of Head and Neck Cancer

Cited by 45 publications

References 46 publications

Effect of Human Development Index and other socioeconomic factors on mortality-to-incidence ratio of lips and oral cavity cancer in Mexican states: an ecological study

Effect of Human Development Index and other socioeconomic factors on mortality-to-incidence ratio of lips and oral cavity cancer in Mexican states: an ecological study

High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma

Figure 4: ceRNA networks centred on miR-197-5p and miR-6808-5p.

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