Global burden of preterm birth

Walani, Salimah R.

doi:10.1002/ijgo.13195

Cited by 639 publications

(537 citation statements)

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“…Preterm birth (PTB) is a pregnancy complication that affects about 11% of births worldwide and is associated with increased maternal and neonate morbidity and mortality [ 98 ]. An altered inflammatory status appears to be associated with PTB.…”

Section: Role Of Curcumin In Pregnancymentioning

confidence: 99%

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

et al. 2020

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Curcumin, the main polyphenol contained in turmeric root (Curcuma longa), has played a significant role in medicine for centuries. The growing interest in plant-derived substances has led to increased consumption of them also in pregnancy. The pleiotropic and multi-targeting actions of curcumin have made it very attractive as a health-promoting compound. In spite of the beneficial effects observed in various chronic diseases in humans, limited and fragmentary information is currently available about curcumin’s effects on pregnancy and pregnancy-related complications. It is known that immune-metabolic alterations occurring during pregnancy have consequences on both maternal and fetal tissues, leading to short- and long-term complications. The reported anti-inflammatory, antioxidant, antitoxicant, neuroprotective, immunomodulatory, antiapoptotic, antiangiogenic, anti-hypertensive, and antidiabetic properties of curcumin appear to be encouraging, not only for the management of pregnancy-related disorders, including gestational diabetes mellitus (GDM), preeclampsia (PE), depression, preterm birth, and fetal growth disorders but also to contrast damage induced by natural and chemical toxic agents. The current review summarizes the latest data, mostly obtained from animal models and in vitro studies, on the impact of curcumin on the molecular mechanisms involved in pregnancy pathophysiology, with the aim to shed light on the possible beneficial and/or adverse effects of curcumin on pregnancy outcomes.

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Section: Role Of Curcumin In Pregnancymentioning

confidence: 99%

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

et al. 2020

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“…In this special section of IJGO, Preterm Birth Working Group members discuss selected topics and potential causes of preterm birth that could be addressed in order to reduce the incidence. Walani 6 provides a global perspective on rates, including recent WHO data 7 . Cobo, Kacerovsky, and Jacobsson provide an overview of risk factors, including the microbiome 8 .…”

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confidence: 99%

Preterm birth: A clinical enigma and a worldwide public health concern

Jacobsson

Simpson

2020

Intl J Gynecology & Obste

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Delivery before 37 weeks of gestation is a major worldwide public health concern, occurring in 10% of all births globally. This problem exists both in low-and middle-income countries (LMIC) and in high-income countries. In a 2012 report by WHO, March of Dimes, Save the Children, and The Partnership for Maternal, Newborn and Child Health-'Born Too Soon'-it was stated that in 2010, 15 million babies were born preterm, namely before 37 weeks of gestation. 1 Over 1 million of these preterm babies died. Surviving infants had an increased risk of learning disabilities, as well as visual and auditory problems. The magnitude of the problems is inversely related to gestational age at birth. For example, a linear decline in the need for special education can be shown for births from gestational week 24 to week 41. 2 At the time of the 'Born Too Soon' report, 1 only a few interventions were generally accepted: elimination of early elective deliveries; progesterone or progestational agents if a prior preterm birth had occurred; single embryo transfer in Assisted Reproductive Technologies (ART); cerclage for cervical insufficiency; cessation of smoking. If all of these guidelines were followed, however, the reduction in preterm birth was only a modest 9.6%-9.1%. 3As a result of these realities, the FIGO Working Group on Preterm Birth was initiated in 2014, a collaborative agreement between FIGO and the March of Dimes, both Non-State Actors (NSA) in official relations with WHO. Terms of reference included identification of risk factors, strategies to communicate clinical significance, and preparation of enduring educational material for use by member societies and for presentation at international FIGO meetings and elsewhere. These included FIGO World Congresses in Vancouver in 2015 and in Rio de Janeiro in 2018. Site-specific workshops and presentations were held elsewhere, in particular South America (Costa Rica, Uruguay). The success of these and other ventures have resulted in extension of the activities of Working Group. In 2016 the Working Group completed an exhaustive individual patient data meta-analysis encompassing 4.1 million births in California and four countries (Czech Republic, Sweden, New Zealand, Slovenia). 4 Of preterm birth pregnancies, 2/3 lacked a known biological basis. As result, attention expanded to elucidate the biological basis (etiology) of preterm birth. Enthusiasm for exploring the potential beneficial treatment with vaginal progesterone and 17-alpha OH progesterone caproate continued. Perturbations of the vaginal microbiome as a predisposing factor in preterm birth are perhaps one explanation for the markedly higher risk in African-Americans. Heritable factors have long been known to exist, and in 2017 a genomewide association study of 43 568 women discovered six genes of significance. 5 Work continues in other related fields-regulatory genes, glycobiology, maternal stress, sleep disturbance, and anatomic changes in the cervix and vagina. In this special section of IJGO, Preterm Birth Working Gro...

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“…Although 5% (5) of the study participants experienced preterm birth, two of these had already been warned of the risk of preterm birth by a biomedical test. Considering that the average proportion of women who undergo preterm birth worldwide is 11% [ 74 ], it is unlikely that a causal relationship exists between rTMS and preterm birth. However, further research on this is needed.…”

Section: Discussionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation treatment for peripartum depression: systematic review & meta-analysis

Lee

Kim

Kwon

2021

BMC Pregnancy Childbirth

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Background Peripartum depression is a common disorder with very high potential hazards for both the patients and their babies. The typical treatment options include antidepressants and electroconvulsive therapy. However, these treatments do not ensure the safety of the fetus. Recently, repetitive transcranial magnetic stimulation has emerged as a promising treatment for neuropathies as well as depression. Nevertheless, many studies excluded pregnant women. This systematic review was conducted to confirm whether repetitive transcranial magnetic stimulation was a suitable treatment option for peripartum depression. Methods We performed a systematic review that followed the PRISMA guidelines. We searched for studies in the MEDLINE, PsycINFO, EMBASE, and Cochrane library databases published until the end of September 2020. Eleven studies were selected for the systematic review, and five studies were selected for quantitative synthesis. Data analysis was conducted using Comprehensive Meta-Analysis 3 software. The effect size was analyzed using the standardized mean difference, and the 95% confidence interval (CI) was determined by the generic inverse variance estimation method. Results The therapeutic effect size of repetitive transcranial magnetic stimulation for peripartum depression was 1.394 (95% CI: 0.944–1.843), and the sensitivity analysis effect size was 1.074 (95% CI: 0.689–1.459), indicating a significant effect. The side effect size of repetitive transcranial magnetic stimulation for peripartum depression was 0.346 (95% CI: 0.214–0.506), a meaningful result. There were no severe side effects to the mothers or fetuses. Conclusions From various perspectives, repetitive transcranial magnetic stimulation can be considered an alternative treatment to treat peripartum depression to avoid exposure of fetuses to drugs and the severe side effects of electroconvulsive therapy. Further research is required to increase confidence in the results.

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Global burden of preterm birth

Cited by 639 publications

References 6 publications

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

Preterm birth: A clinical enigma and a worldwide public health concern

Repetitive transcranial magnetic stimulation treatment for peripartum depression: systematic review & meta-analysis

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