Global Burden of Stroke

Katan, Mira; Luft, Andreas R.

doi:10.1055/s-0038-1649503

Cited by 1,623 publications

(1,124 citation statements)

References 45 publications

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“…Stroke, also named as brain attack, is a complex neurological disease and the second most common cause of death in the world (Katan & Luft, 2018;Naghavi et al, 2017). With the characteristics of high incidence rate, high disability rate, high death rate, high recurrence rate and more complications, it gives to a serious hazard to human health and safety (Gorelick, 2019).…”

Section: Introductionmentioning

confidence: 99%

The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population

Yang

Wang

et al. 2019

Brain and Behavior

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Aims:Stroke is a complicated neurological disease and the second leading cause of death in the world. We aimed to investigate the association between CYP24A1 genetic polymorphisms and ischemic stroke risk. Methods:In this case-control study, four single-nucleotide polymorphisms of CYP24A1 were selected and genotyped by MassARRAY platform in Chinese Han population. Odds ratios and 95% confidence intervals were calculated via logistic regression analysis with adjustment in genetic models. Results:Our results indicated that CYP24A1 variant (rs1570669) was associated with the decreased risk of ischemic stroke (OR = 0.60, p < .001). Stratification analysis showed that the rs6068816 could enhance the ischemic stroke risk by 1.64 times (OR = 1.64, p = .028), while rs1570669 played protective role (OR = 0.63, p = .044) in age >64 years. The rs2762934 had an increased ischemic stroke susceptibility (OR = 1.62, p = .033); however, rs1570669 might reduce stroke risk (OR = 0.61, p = .015) in age ≤64 years. The rs1570669 depressed ischemic stroke susceptibility both in female and male patients (OR = 0.46, p = .002; OR = 0.69, p = .033, respectively), and rs2296241 would weaken the risk in male (OR = 0.63, p = .012). The rs1570669 was associated with decreased risk of ischemic stroke with hypertension (OR = 0.56, p = .042). Conclusion:Our study gave the evidences that CYP24A1 genetic polymorphisms were significantly associated with ischemic stroke patients, which would provide useful information of assessment or possible diagnostic markers for ischemic stroke. K E Y W O R D SCYP24A1, genetic polymorphisms, ischemic stroke

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Section: Introductionmentioning

confidence: 99%

The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population

Yang

Wang

et al. 2019

Brain and Behavior

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“…We used the following values to calculate the sample size in our study: α = 0.05, β = 0.20, p1 = 78% (the proportion of vitamin D deficiency in SVD), p0 = 60% (the proportion of vitamin D deficiency in controls), q0 = 1-p0 = 40%, q1 = 1-p1 = 22%, 1:1 design, two sides, the sample size N was about 100. The following formulae were used, N = 2(Z α/2 + Z β ) 2…”

Section: Subjectsmentioning

confidence: 99%

“…Stroke is now recognized to be the second leading cause of death worldwide [1,2] and the first one in China [3]. Small vessel disease (SVD) is considered to cause 20 to 25% of strokes.…”

Section: Introductionmentioning

confidence: 99%

The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China

Shan

et al. 2019

BMC Neurol

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Background The exact relationship between 25-hydroxyvitamin D [25(OH) D] levels and small vessel disease (SVD) are not clear in China. The aim of this study was to determine such the association between 25(OH) D and SVD in China. Methods We retrospectively enrolled 106 patients with SVD and 115 controls between Jan 2017 and Dec 2017. All the subjects were categorized into three subgroups according to the level of 25 (OH) D: vitamin D deficiency (< 12 ng/ml), insufficiency (12–20 ng/ml) and sufficiency (> 20 ng/ml). Results Among 106 SVD patients, 80 (75.5%) were men and the mean age was 61.6 ± 13.2 years. The deficiency of 25(OH) D was observed in 76 (71.7%) of SVD patients and 47 (40.9%) of controls ( P = 0.001). Compared with controls, patients with SVD were more likely to be male, a stroke history, smokers, with hyperlipidemia, higher systolic and diastolic blood pressure and low-density lipoprotein, and lower of 25(OH)D level ( P < 0.05). Logistic regression analysis revealed the level of 25 (OH) D as an independent predictor of SVD ( OR 0.772, 95% CI 0.691–0.862, P = 0.001). Compared with the sufficient 25 (OH) D group, the ORs of SVD in deficient and insufficient 25(OH)D group were 5.609 (95% CI 2.006–15.683) and 1.077 (95% CI : 0.338–3.428) after adjusting for potential confounders, respectively. In hypertensives with vitamin D deficient and insufficient group compared with sufficient group, the ORs of SVD increased to 9.738 (95% CI 2.398–39.540) and 1.108 (95% CI 0.232–5.280), respectively ( P interaction = 0.001). Conclusion We found significant associations between SVD and 25(OH)D deficiency. The combined presence of hypertension and vitamin D deficiency increased the probability of developing SVD. Our findings will warrant further prospective studies in the future.

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“…Cerebrovascular disease is one of the leading causes of death and disability worldwide, and will continue to represent a challenge to healthcare services in the future …”

Section: Introductionmentioning

confidence: 99%

Carotid Atherosclerosis is Associated with Middle Cerebral Artery Pulsatility Index

Vigen

Ihle‐Hansen

Lyngbakken

et al. 2019

Journal of Neuroimaging

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BACKGROUND AND PURPOSE Pulsatility index (PI) in the middle cerebral artery (MCA) is considered a measure of peripheral vascular resistance. Several established cardiovascular risk factors are common for both MCA PI and carotid atherosclerosis. Accordingly, in the present study we hypothesized an association between ultrasound‐derived indices of carotid atherosclerosis and MCA PI. METHODS All residents in Akershus County, born in 1950, were invited to a cardiovascular examination, The Akershus Cardiac Examination (ACE) 1950 Study (2012‐2015). A thorough ultrasound examination was performed to assess indices of atherosclerosis in the carotid arteries, and PI in the MCAs. In all, 3154 (85.1%) had adequate transcranial and carotid data. Associations between indices of carotid atherosclerosis and MCA PI were assessed by regression analyses adjusted for established cardiovascular risk factors. RESULTS Mean age was 64 (standard deviation [SD]: .6) years, and 1,357 (43%) were women. Mean MCA PI was .97 (SD: .17). Participants in the upper quartile of MCA PI had higher pulse pressure, more frequently hypertension, diabetes mellitus, and a history of coronary artery disease. Both carotid plaque score (B .007 [95% CI: .003‐.010]) and carotid intimamedia thickness (B .173 [95% CI: .120‐.226]) were significantly associated with MCA PI in adjusted analysis. The model R2 was .055. CONCLUSION In a population‐based sample of middle‐aged adults, ultrasound‐derived indices of carotid atherosclerosis were independently associated with MCA PI. However, the overall explained variance of MCA PI was low, suggesting other factors than atherosclerosis and cardiovascular risk factors to play an important role for MCA PI.

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Global Burden of Stroke

Cited by 1,623 publications

References 45 publications

The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population

The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population

The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China

Carotid Atherosclerosis is Associated with Middle Cerebral Artery Pulsatility Index

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