Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis

Flaxman, Seth; Tahhan, Nina; Bourne, Rupert; Ackland, Peter; Arditi, Aries; Barkana, Yaniv; Bozkurt, Banu; Braithwaite, Tasanee; Bron, Alain M.; Budenz, Donald L.; Cai, Feng; Casson, Robert J.; Chakravarthy, Usha; Choi, Jaewan; Cicinelli, Maria Vittoria; Congdon, Nathan; Dandona, Rakhi; Dandona, Lalit; Das, Aditi; Dekaris, Iva; Monte, Monte A. Del; Deva, Jenny P; Dreer, Laura E.; Ellwein, Leon B.; Frazier, Marcela; Frick, Kevin D.; Friedman, David S.; Furtado, João M.; Gao, Hua; Gazzard, Gus; George, Ronnie; Gichuhi, Stephen; González, Víctor H.; Hammond, Billy R.; Hartnett, M. Elizabeth; He, Minguang; Hejtmancik, J. F.; Hirai, Flávio E.; Huang, John J.; Ingram, April; Javitt, Jonathan C.; Jonas, Jost B.; Joslin, Charlotte E.; Keeffe, Jill; Kempen, John H.; Khairallah, Moncef; Khanna, Rohit C; Kim, Judy; Lambrou, George N.; Lansingh, Van C.; Lanzetta, Paolo; Leasher, Janet; Lim, Jennifer; Limburg, Hans; Mansouri, Kaweh; Mathew, Anu; Morse, Alan R.; Muñoz, Beatriz; Musch, David C.; Naidoo, Kovin; Nangia, Vinay; Palaiou, M.; Parodi, Maurizio Battaglia; Peña, Fernando Yaacov; Pesudovs, Konrad; Pető, Tünde; Quigley, Harry A.; Raju, Murugesan; Ramulu, Pradeep Y.; Rankin, Zane; Resnikoff, Serge; Dana, Reza; Robin, Alan L.; Rossetti, Luca; Saaddine, Jinan B.; Sandar, Mya; Serle, Janet B.; Shen, Tueng T.; Shetty, Rajesh; Sieving, Pamela C.; Silva, Juan Carlos; Silvester, Alex; Sitorus, Rita S; Stambolian, Dwight; Stevens, Gretchen A; Taylor, Hugh R.; Tejedor, Jaime; Tielsch, James M.; Tsilimbaris, Miltiadis K.; Meurs, Jan van; Varma, Rohit; Virgili, Gianni; Wang, Ya Xing; Wang, Ningli; West, Sheila K.; Wiedemann, Peter M.; Wong, Tien Yin; Wormald, Richard; Zheng, Yingfeng

doi:10.1016/s2214-109x(17)30393-5

Cited by 2,502 publications

(1,730 citation statements)

References 14 publications

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“…Corneal scarring is the cause of blindness for millions of individuals, especially in developing countries . The current standard of care is corneal transplantation to replace the scarred corneal tissue.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle-Mediated Delivery of miRNA

Shojaati

Khandaker

Funderburgh

et al. 2019

Stem Cells Translational Medicine

131

114

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Mesenchymal stem cells from corneal stromal stem cells (CSSC) prevent fibrotic scarring and stimulate regeneration of transparent stromal tissue after corneal wounding in mice. These effects rely on the ability of CSSC to block neutrophil infiltration into the damaged cornea. The current study investigated the hypothesis that tissue regeneration by CSSC is mediated by secreted extracellular vesicles (EVs). CSSC produced EVs 130–150 nm in diameter with surface proteins that include CD63, CD81, and CD9. EVs from CSSC reduced visual scarring in murine corneal wounds as effectively as did live cells, but EVs from human embryonic kidney (HEK)293T cells had no regenerative properties. CSSC EV treatment of wounds decreased expression of fibrotic genes Col3a1 and Acta2, blocked neutrophil infiltration, and restored normal tissue morphology. CSSC EVs labeled with carboxyfluorescein succinimidyl ester dye, rapidly fused with corneal epithelial and stromal cells in culture, transferring microRNA (miRNA) to the target cells. Knockdown of mRNA for Alix, a component of the endosomal sorting complex required for transport, using siRNA, resulted in an 85% reduction of miRNA in the secreted EVs. The EVs with reduced miRNA were ineffective at blocking corneal scarring. Furthermore, CSSC with reduced Alix expression also lost their regenerative function, suggesting EVs as an obligate component in the delivery of miRNA. The results of these studies support an essential role for extracellular vesicles in the process by which CSSC cells block scarring and initiate regeneration of transparent corneal tissue after wounding. EVs appear to serve as a delivery vehicle for miRNA, which affects the regenerative action. Stem Cells Translational Medicine 2019;8:1192–1201

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Section: Discussionmentioning

confidence: 99%

Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle-Mediated Delivery of miRNA

Shojaati

Khandaker

Funderburgh

et al. 2019

Stem Cells Translational Medicine

131

114

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“…Diabetic retinopathy (DR) is among the leading global causes of blindness [1]. It is a microangiopathy that affects more than one third of all diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy

Dimitrova¹,

Chihara²

2019

Ophthalmologica

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The aim of this narrative mini review is to analyze optical coherence tomography angiography (OCTA) parameters from reports that involved both superficial and deep vascular layers in patients with diabetes and to assess their relevance for the pathogenesis of diabetic retinopathy (DR). Papers published from January 2015 to August 2018 describing the use of OCTA in diabetes were identified and reviewed through a Medline/PubMed search. OCTA studies suggest that parameters are altered in patients with diabetes in all retinal vascular layers. From all included studies that evaluated both the superficial and the deep vascular layer, a number of studies suggested that the deep vascular layer was affected at an earlier stage of DR. OCTA parameter alterations were more prominent in the deep vascular layer than in the superficial vascular layer in patients with DR, and deep-vascular-layer alterations were most evident in patients with diabetic macular edema. Regarding that retinal venules originate from the deep vascular layer of the retina, alteration of OCTA parameters at the deep vascular layer in diabetic patients may imply a predominant affection of the venous side of the retinal vascular system in the pathogenesis of DR.

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“…Cataract is a leading cause of treatable vision loss in Australia1 and globally 2. Given the considerable burden of cataract and the safety and efficacy of treatment, it is not surprising that cataract surgery is the most commonly performed elective surgical procedure in Australia, with 229 693 operations performed in 2013–2014 3.…”

Section: Introductionmentioning

confidence: 99%

Population-based assessment of visual acuity outcomes following cataract surgery in Australia: the National Eye Health Survey

et al. 2018

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Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis

Abstract: Brien Holden Vision Institute.

Cited by 2,502 publications

References 14 publications

Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle-Mediated Delivery of miRNA

Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle-Mediated Delivery of miRNA

Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy

Population-based assessment of visual acuity outcomes following cataract surgery in Australia: the National Eye Health Survey

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