Global Cerebral Blood Flow in Relation to Cognitive Performance and Reserve in Subjects with Mild Memory Deficits

Ponto, Laura L. Boles; Magnotta, Vincent A.; Moser, David J.; Duff, Kevin; Schultz, Susan K.

doi:10.1007/s11307-006-0066-z

Cited by 20 publications

(23 citation statements)

References 35 publications

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“…Additionally, gCBF was measured a third time as participants completed the counting task following the administration of the carbonic anhydrase inhibitor acetazolamide (ACZ), in order to assess cerebrovascular reserve, the ability of the brain to increase blood flow when induced to do so. Technical methodology was implemented as previously described for work at this institution (Boles Ponto, Schultz, Watkins, & Hichwa, 2004; Hichwa, Ponto, & Watkins, 1995; Hurtig et al, 1994; Ponto, Magnotta, Moser, Duff, & Schultz, 2006). Imaging was performed on a Siemens ECAT EXACT HR+ scanner.…”

Section: Methodsmentioning

confidence: 99%

Cerebral blood flow and neuropsychological functioning in elderly vascular disease patients

Moser

Ponto

Miller

et al. 2012

Journal of Clinical and Experimental Neuropsychology

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This study was designed to determine the relationships between PET-based quantitative measures of cerebral blood flow and cerebrovascular reserve and neuropsychological functioning in elderly individuals with atherosclerotic vascular disease. It was hypothesized that cerebrovascular function would be significantly associated with neuropsychological functioning. Results showed that both baseline global cerebral blood flow and cerebrovascular reserve were significantly associated with global neuropsychological functioning, when controlling for age and sex. Cerebrovascular reserve was additionally associated with performance on measures of memory and attention. Additional research is needed to determine whether measures of cerebral blood flow can be used to predict cognitive decline.

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Section: Methodsmentioning

confidence: 99%

Cerebral blood flow and neuropsychological functioning in elderly vascular disease patients

Moser

Ponto

Miller

et al. 2012

Journal of Clinical and Experimental Neuropsychology

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“…As pointed out earlier, vasoreactivity, or cerebrovascular reserve [15], is the capacity of brain vasculature to enhance flow above basal levels in response to a challenge. Thus, it is possible that CVR CO2 measurement could reveal dysfunction earlier than CBF in still relatively healthy tissue and could serve as a sort of “stress test” for brain circulation.…”

Section: Cvrco2 or Cbf Impairment: Which Comes Earlier?mentioning

confidence: 99%

“…Vasoreactivity is also referred to as cerebrovascular reserve [15], emphasizing the capability of the vascular system to increase its performance above resting blood flow in response to a challenge. Thus CVR CO2 can be considered a measure of vascular health.…”

mentioning

confidence: 99%

Cerebrovascular Reactivity to Carbon Dioxide in Alzheimer's Disease

Glodzik

Randall

Rusinek

et al. 2013

JAD

115

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There is growing evidence that cerebrovascular reactivity to carbon dioxide (CVRCO2) is impaired in Alzheimer’s disease (AD). Preclinical and animal studies suggest chronic hypercontractility in brain vessels in AD. We review (a) preclinical studies of mechanisms for impaired CVRCO2 in AD; (b) clinical studies of cerebrovascular function in subjects with AD dementia, mild cognitive impairment (MCI), and normal cognition. Although results of clinical studies are inconclusive, an increasing number of reports reveal an impairment of vascular reactivity to carbon dioxide in subjects with AD, and possibly also in MCI. Thus, CVRCO2 may be an attractive means to detect an early vascular dysfunction in subjects at risk.

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“…Physical exercise increases cerebral blood volume (Swain et al, 2003;Pereira et al, 2007), cerebral blood flow (Yancey et al, 1993), blood-brainbarrier permeability (Shama et al, 1991), blood vessel perimeter (Van Praag et al, 2005), and angiogenesis (Swain et al, 2003;Van Praag et al, 2005;Ding et al, 2006). These effects of exercise on the cerebrovascular system may in turn improve brain function, as suggested by abundant data showing a positive correlation between cerebral perfusion and cognition (Berman et al, 1988;Boles Ponto et al, 2006;Pereira et al, 2007). An increased cerebral blood flow can promote brain function not only by facilitating transport of nutrients and oxygen but also by increasing transport of neurotrophic factors that support processes of neuronal plasticity and neurogenesis.…”

Section: Introductionmentioning

confidence: 99%

Physical exercise leads to rapid adaptations in hippocampal vasculature: Temporal dynamics and relationship to cell proliferation and neurogenesis

et al. 2009

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Increased levels of angiogenesis and neurogenesis possibly mediate the beneficial effects of physical activity on hippocampal plasticity. This study was designed to investigate the temporal dynamics of exercise-induced changes in hippocampal angiogenesis and cell proliferation. Mice were housed with a running wheel for 1, 3, or 10 days. Analysis of glucose transporter Glut1-positive vessel density showed a significant increase after 3 days of wheel running. Cell proliferation in the dentate gyrus showed a trend towards an increase after 3 days of running and was significantly elevated after 10 days of physical exercise. Ten days of wheel running resulted in a near-significant increase in the number of immature neurons, as determined by a doublecortin (DCX) staining. In the second part of the study, the persistence of the exercise-induced changes in angiogenesis and cell proliferation was determined. The running wheel was removed from the cage after 10 days of physical activity. Glut-1 positive vessel density and hippocampal cell proliferation were determined 1 and 6 days after removal of the wheel. Both parameters had returned to baseline 24 h after cessation of physical activity. The near-significant increase in the number of DCX-positive immature neurons persisted for at least 6 days, indicating that new neurons formed during the period of increased physical activity had survived. Together these experiments show that the hippocampus displays a remarkable angiogenic and neurogenic plasticity and rapidly responds to changes in physical activity.

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Global Cerebral Blood Flow in Relation to Cognitive Performance and Reserve in Subjects with Mild Memory Deficits

Abstract: Cognitive reserve appears analogous to cardiac reserve. The ability to alter gCBF paralleled performance on general cognitive measures, was enhanced in higher levels of cognitive reserve, and was impaired in individuals who no longer appear to benefit from repeated exposure to testing.

Cited by 20 publications

References 35 publications

Cerebral blood flow and neuropsychological functioning in elderly vascular disease patients

Cerebral blood flow and neuropsychological functioning in elderly vascular disease patients

Cerebrovascular Reactivity to Carbon Dioxide in Alzheimer's Disease

Physical exercise leads to rapid adaptations in hippocampal vasculature: Temporal dynamics and relationship to cell proliferation and neurogenesis

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