Worldwide photovoltaic power generation is affected by deposited dust on photovoltaic (PV) systems, which creates soiling losses. In this work, factors that have a detrimental influence on dust deposition and an impact on PV systems performance were reviewed. The different ways that dust deposition can be a barrier for India’s energy security plan involving PV were also discussed. Different available cleaning techniques were also introduced. The nature, size, and morphology of dust particles vary with geographical location. Any increase of the PV tilt angle, or high wind speed and heavy rain showers reduce dust deposition. Deposited dust reduces the incident transmitted light on the PV, which has an adverse impact on the reduction of short circuit current. However, the open-circuit voltage has a reduced effect due to dust deposition. The enhancement of temperature caused by dust-covered PVs is still a debatable area. A universal cleaning technique is required to eliminate the soiling losses from PV. India has a solar mission to generate 100 GW of PV power by 2022. However, India’s poor air quality can undermine efforts to achieve this target.