Global coagulation assays in healthy controls: are there compensatory mechanisms within the coagulation system?

Global coagulation assays in patients with diabetes mellitus

“…Another potential reason for the paradoxically low global coagulation parameters, as we have previously hypothesized, could be a compensatory response of the coagulation system in response to endothelial dysfunction. We have previously described that in the healthy control population that patients with “flattened” thrombin generation curves had poorer lipid profile and were males 18,19 . Of note, the LURIC study has also previously reported that ETP was inversely associated with cardiovascular death and endothelial dysfunction 35 .…”

“…We have previously described that in the healthy control population that patients with "flattened" thrombin generation curves had poorer lipid profile and were males. 18,19 Of note, the LURIC study has also previously reported that ETP was inversely associated with cardiovascular death and endothelial dysfunction. 35 This is consistent with the findings in this study in which ETP is lower in patients with diabetes compared with healthy controls when those with microvascular complications were excluded.…”

“…Written informed consent was obtained from every study participant. The data from the diabetes cohort were compared with healthy controls (n = 153) recruited between August 2013 and August 2019 18,19 . The healthy controls were recruited from staff and family members as well as through poster advertisement in the hospital and word of mouth.…”

“…The data from the diabetes cohort were compared with healthy controls (n = 153) recruited between August 2013 and August 2019. 18,19 The healthy controls were recruited from staff and family members as well as through poster advertisement in the hospital and word of mouth. In addition to these exclusion criteria, the healthy controls were not known to have any modifiable cardiovascular risk factors nor were on any medications that may modify the coagulation parameters such as antiplatelet, oral contraceptive, or hormone replacement therapy.…”

Medical gloves modified by a one-minute spraying process with blood-repellent, antibacterial and wound-healing abilities

“…22,23 As an anticoagulant, SC in MS could combine with calcium ions in the blood to prevent blood from coagulating and sticking to the surface of the gloves. 24,25 Also, previous studies have shown that quaternary ammonium nitrogen has excellent antibacterial properties for Gram-positive bacteria and Gram-negative bacteria, [26][27][28] which indicated that the modification of quaternary ammonium nitrogen on the surface of the medical gloves could effectively improve their antibacterial abilities. As shown in Scheme 1, blood adhesion always appeared on the surface of ordinary gloves when operating.…”