Global disease burden linked to diet high in red meat and colorectal cancer from 1990 to 2019 and its prediction up to 2030

Abstract

BackgroundNumerous studies have already identified an association between excessive consumption of red meat and colorectal cancer (CRC). However, there has been a lack of detailed understanding regarding the disease burden linked to diet high in red meat and CRC.ObjectiveWe aim to offer evidence-based guidance for developing effective strategies that can mitigate the elevated CRC burden in certain countries.MethodsWe used the data from the Global Burden of Disease (GBD) Study 2019 to evaluate global, regional, and national mortality rates and disability-adjusted Life years (DALYs) related to diet high in red meat. We also considered factors such as sex, age, the socio-demographic index (SDI), and evaluated the cross-national inequalities. Furthermore, we utilized DALYs data from 204 countries and regions to measure cross-country inequalities of CRC by calculating the slope index of inequality and concentration index as standard indicators of absolute and relative inequalities.DiscussionThe results show that globally, the age-standardized mortality rate (ASMR) and age-standardized disability adjusted life year rate (ASDR) related to CRC due to diet high in red meat have decreased, with estimated annual percent change (EAPCs) of −0.32% (95% CI −0.37 to −0.28) and-0.18% (95% CI −0.25 to −0.11). Notably, the burden was higher among males and the elderly. The slope index of inequality rose from 22.0 (95% CI 18.1 to 25.9) in 1990 to 32.9 (95% CI 28.3 to 37.5) in 2019 and the concentration index fell from 59.5 (95% CI 46.4 to 72.6) in 1990 to 48.9 (95% CI 34.6 to 63.1) in 2019. Also, according to our projections, global ASDR and ASMR might tend to increase up to 2030.ConclusionASMR and ASDR for CRC associated with high red meat diets declined globally from 1990 to 2019, but the absolute number of cases is still rising, with men and the elderly being more affected. CRC associated with diets high in red meat exhibits significant income inequality, placing a disproportionate burden on wealthier countries. Moreover, according to our projections, ASMR and ASDR are likely to increase globally by 2030. In order to address this intractable disease problem, understanding changes in global and regional epidemiologic trends is critical for policy makers and others.

The global burden, trends, and inequalities of individuals with developmental and intellectual disabilities attributable to iodine deficiency from 1990 to 2019 and its prediction up to 2030

“…The slope index of inequality is determined through regression analysis of the national YLDs ratio across all age groups against a relative positional scale linked to the SDI. It’s defined as the midpoint of the population’s cumulative range ranked according to the SDI ( 33 , 34 ). Heteroscedasticity is addressed using a weighted regression model.…”

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“…The slope index of inequality is determined through regression analysis of the national YLDs ratio across all age groups against a relative positional scale linked to the SDI. It's defined as the midpoint of the population's cumulative range ranked according to the SDI (33,34). Heteroscedasticity is addressed using a weighted regression model.…”

Image_1.JPEG

“…The slope index of inequality is determined through regression analysis of the national YLDs ratio across all age groups against a relative positional scale linked to the SDI. It's defined as the midpoint of the population's cumulative range ranked according to the SDI (33,34). Heteroscedasticity is addressed using a weighted regression model.…”