Global Disparities in Wilms Tumor

Cunningham, Megan E.; Klug, Theodore; Nuchtern, Jed G.; Chintagumpala, Murali; Venkatramani, Rajkumar; Lubega, Joseph; Naik‐Mathuria, Bindi

doi:10.1016/j.jss.2019.10.044

Cited by 79 publications

(78 citation statements)

References 58 publications

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“…Wilms tumor (WT) is one of the major successes of pediatric oncology with tremendous advances and improvement of outcome over the past 50 years 1,2 . The improved survival has been attributed to early diagnosis; focused research; collaborative efforts among surgeons, pathologists, pediatricians, and radiation oncologists; and better supportive care 1–3 . Despite this great progress, there is evidence that survival in most low‐income countries (LICs) is substantially lower than that in the high‐income countries (HICs) 1,4 .…”

Section: Introductionmentioning

confidence: 99%

“…The improved survival has been attributed to early diagnosis; focused research; collaborative efforts among surgeons, pathologists, pediatricians, and radiation oncologists; and better supportive care 1–3 . Despite this great progress, there is evidence that survival in most low‐income countries (LICs) is substantially lower than that in the high‐income countries (HICs) 1,4 . Recent publications indicate that the overall survival in HICs approximates 90%, while survival in most LICs is less than 50% 1–5 .…”

Section: Introductionmentioning

confidence: 99%

“…Despite this great progress, there is evidence that survival in most low‐income countries (LICs) is substantially lower than that in the high‐income countries (HICs) 1,4 . Recent publications indicate that the overall survival in HICs approximates 90%, while survival in most LICs is less than 50% 1–5 . However, the statistic assumes a frightening dimension when considered against the backdrop of the finding that more than 80% of children with cancer worldwide live in LICs, where the situation is more difficult and the level of care considerably lower than the global benchmark 6 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Wilms tumor in Africa: A systematic review of management challenges and outcome in two decades (2000‐2019)

Ekenze

Okafor

Obasi

et al. 2020

Pediatric Blood & Cancer

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We performed a systematic review to highlight trends in management and outcome of Wilms tumor (WT) in Africa in the past two decades (2000-2019). Twenty-seven studies involving 2250 patients were analyzed. Overall, barring regional variations, 57.7% of the cases presented with advanced disease, 57.3% completed planned treatment, and survival was 56.5%. The publications in the two decades did not show significant differences in proportions of cases with advanced disease, completion of treatment rate, and cases lost to follow up. However, significantly more cases received preoperative chemotherapy, and survival improved in the last decade (2010-2019) compared to the earlier decade (2000-2009). Survival of WT in Africa might have improved in the last decade, but challenges of delayed presentation and abandonment of treatment have persisted. Measures that will encourage early access to expert care as well as improve on treatment compliance may further improve survival of WT in Africa.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Wilms tumor in Africa: A systematic review of management challenges and outcome in two decades (2000‐2019)

Ekenze

Okafor

Obasi

et al. 2020

Pediatric Blood & Cancer

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“…1,2 In Western countries and China, the incidence of Wilms tumor is approximately 8.3 per million and 4.2 per million, respectively. 3,4 More than 80% of the cases are diagnosed before the ages of 5 years and the median age at diagnosis is 3.5 years. 3 The abnormal differentiation and proliferation of pluripotent embryonic renal precursors is considered to give rise to Wilms tumor.…”

Section: Introductionmentioning

confidence: 99%

“…Wilms tumor is the most common malignant renal tumor in children, accounting for 5% of extracranial embryonal tumors 1,2 . In Western countries and China, the incidence of Wilms tumor is approximately 8.3 per million and 4.2 per million, respectively 3,4 . More than 80% of the cases are diagnosed before the ages of 5 years and the median age at diagnosis is 3.5 years 3 .…”

Section: Introductionmentioning

confidence: 99%

METTL3 polymorphisms and Wilms tumor susceptibility in Chinese children: A five‐center case–control study

Zhou

Hua

et al. 2020

The Journal of Gene Medicine

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Background: Wilms tumor is a common pediatric tumor worldwide. Methyltransferase like 3 (METTL3) is a core gene of the N 6-methyladenosine (m 6 A) modification that widely affects the transcription of tumor-related genes in eukaryotes. METTL3 has been extensively investigated in various tumors but not Wilms tumor. Methods: We describe a five-center case-control study with 414 patients and 1199 controls aiming to explore the associations between METTL3 polymorphisms (rs1061026 T>G, rs1061027 C>A, rs1139130 A>G and rs1263801 G>C) and Wilms tumor susceptibility. A TaqMan real-time polymerase chain reaction was performed for genotyping. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported as evaluation indicators to determine any associations. Results: Referring to the preliminary analysis results, protective genotypes were identified as rs1061026 TG/GG, rs1061027 CA/AA, rs1139130 GG and rs1263801 GC/CC. The children with three protective genotypes were less likely to develop Wilms tumor than children without protective genotypes (adjusted OR = 0.68, 95% CI = 0.46-0.999, p = 0.0496). Similarly, stratified analysis of the subgroup aged > 18 months, carrying 3 or 4 protective genotypes, was a protective factor for Wilms tumor compared to carrying 0-2 protective genotypes (adjusted OR = 0.59 95% CI = 0.39-0.91, p = 0.016). However, we did not observe any other significant results. Conclusions: The combined effect of METTL3 polymorphisms reduce Wilms tumor susceptibility in Chinese children. This conclusion requires further verification.

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Trends in childhood cancer incidence in sub‐Saharan Africa: Results from 25 years of cancer registration in Harare (Zimbabwe) and Kyadondo (Uganda)

Stoeter

Seraphin

Chitsike

et al. 2021

Intl Journal of Cancer

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We examined trends in childhood cancer incidence in sub-Saharan Africa using data from two population-based cancer registries in Harare (Zimbabwe) and Kyadondo (Uganda) with cases classified according to the International Classification of Childhood Cancer and explored reasons for observed variations and changes. Over the whole 25-year period studied, there were only small, and nonsignificant overall trends in incidence. Nevertheless, within the period, peaks in incidence occurred from 1996 to 2001 in Harare (Zimbabwe) and from 2003 to 2006 in Kyadondo (Uganda). Kaposi sarcoma and non-Hodgkin lymphoma accounted for the majority of the cases during these periods. These fluctuations in incidence rates in both registries can be linked to similar trends in the prevalence of HIV, and the availability of antiretroviral therapy. In addition, we noted that, in Harare, incidence rates dropped from 2003 to 2004 and 2007 to 2008, correlating with declines in national gross domestic product. The results indicate that the registration of childhood cancer cases in resource-poor settings is linked to the availability of diagnostic services

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Global Disparities in Wilms Tumor

Cited by 79 publications

References 58 publications

Wilms tumor in Africa: A systematic review of management challenges and outcome in two decades (2000‐2019)

Wilms tumor in Africa: A systematic review of management challenges and outcome in two decades (2000‐2019)

METTL3 polymorphisms and Wilms tumor susceptibility in Chinese children: A five‐center case–control study

Trends in childhood cancer incidence in sub‐Saharan Africa: Results from 25 years of cancer registration in Harare (Zimbabwe) and Kyadondo (Uganda)

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