Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans

Lancaster, Samuel M.; Lee‐McMullen, Brittany; Abbott, Charles W.; Quijada, Jeniffer; Hornburg, Daniel; Park, Heyjun; Perelman, Dalia; Peterson, Dylan; Tang, Mingshu; Robinson, Aaron; Ahadi, Sara; Contrepois, Kévin; Hung, Chia-Jui; Ashland, Melanie; McLaughlin, Tracey; Boonyanit, Anna; Horning, Aaron M.; Sonnenburg, Justin L.; Snyder, M

doi:10.1016/j.chom.2022.03.036

Cited by 68 publications

(47 citation statements)

References 90 publications

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“…In contrast, a recent meta‐analysis confirmed that consumption of high fiber foods such as nuts significantly increased levels of important microbial taxa including Clostridium , Dialister , Lachnospira, and Roseburia 23 . Specific fibers may induce distinct responses, as was recently shown for arabinoxylan that reduces LDL levels, while in the same study long‐chain inulin increased Bifidobacterium levels 24 . In addition, overall dietary patterns might be more important than individual types of fiber in supporting specific taxa as suggested by studies linking Faecalibacterium prausnitzii and Roseburia abundances with increased adherence to a Mediterranean diet (containing high levels of fiber) 25–27 …”

Section: Fiber Effects On the Microbiomementioning

confidence: 86%

“…23 Specific fibers may induce distinct responses, as was recently shown for arabinoxylan that reduces LDL levels, while in the same study long-chain inulin increased Bifidobacterium levels. 24 In addition, overall dietary patterns might be more important than individual types of fiber in supporting specific taxa as suggested by studies linking Faecalibacterium prausnitzii and Roseburia abundances with increased adherence to a Mediterranean diet (containing high levels of fiber). [25][26][27] The degradation of dietary fibers requires specific CAZymes (carbohydrate-active enzymes), which are encoded in the genomes of specific bacterial strains.…”

Section: Ta B L E 2 Evolution Of the Definition Of Prebioticsmentioning

confidence: 99%

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Role of dietary fiber in promoting immune health—An EAACI position paper

Venter

Meyer

Greenhawt

et al. 2022

Allergy

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Recent decades have seen a rapid increase in chronic inflammatory disorders due to inappropriate or misdirected immune responses accompanied by insufficient development of immune regulatory networks. It is generally accepted that changes in environment, lifestyle, and dietary factors may play a role in the miseducation or deficient training of the immune system. 1-3 A shift away from traditional diets rich in plant-based foods to highly processed foods is thought to be particularly important for negatively affecting microbiome diversity and composition, species-specific characteristics, microbial metabolism, and immunological tolerance. 4,5 While we acknowledge that a range of nutritional factors may play a role in influencing immune function and immune regulation, in this review we will focus specifically on one dietary component-fiber.Dietary fiber is a complex dietary component, including carbohydrate polymers and oligomers, which makes up the non-digestible components of food. 6,7 All dietary fibers resist digestion in the small bowel and pass into the large bowel intact but differ in their physiochemical characteristics (e.g., solubility, viscosity, and fermentability), which determine their functionality in the gut and to what degree they are accessible by microbes. Most soluble fibers can be fermented by the gut microbiota, partially or completely, dependent on their chemical structure. Dietary fibers can be defined on the basis of their chemical compounds, on the basis of their functional compounds, or both. Slight differences in definitions of dietary fibers exist due to the wide range of non-digestible fibers that occur in nature. The European Food Safety Authority (EFSA) defines dietary fiber as "non-digestible carbohydrates plus lignin." 8 These include non-starch polysaccharides (NSP) cellulose, hemicelluloses, pectins, hydrocolloids (i.e., gums, mucilages, and β-glucans), resistant oligosaccharides, resistant starch (consisting of physically enclosed starch, some types of raw starch granules, retrograded amylose, chemically and/or physically modified starches), and lignin associated with the dietary fiber polysaccharides (Table 1).Prebiotics are often equated with dietary fibers, but only a subset of dietary fibers qualifies as prebiotics. Not all fibers are equally fermentable by the gut microbiota (Table 1), with considerable inter-individual variation in the potential in vivo fermentability of dietary fiber. [9][10][11] The term "prebiotic" was first defined by Gibson and Roberfroid over 25 years ago as "a non-digestible food ingredient that beneficially affects the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon, and thus improving host health." 12 This definition has evolved to a more simplified version-"a substrate that is selectively utilized by host microorganisms conferring a health benefit." 13 The most common prebiotic fermentable fibers that have been studied for immune health benefits to date include inulin, fructo-oligosacc...

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Section: Fiber Effects On the Microbiomementioning

confidence: 86%

Section: Ta B L E 2 Evolution Of the Definition Of Prebioticsmentioning

confidence: 99%

Role of dietary fiber in promoting immune health—An EAACI position paper

Venter

Meyer

Greenhawt

et al. 2022

Allergy

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“…By contrast, long-chain inulin results in liver inflammation and upregulation of alanine aminotransferase. 203 One of potential mechanisms is that the different structures of dietary fibres contribute to the variants of gut microbiome and their metabolic functionality. 204 However, dietary fibre deficiency has been found to expedite the utilization of glycoproteins by mucus-eroding microbiota, such as Citrobacter rodentium , eventually leading to intestinal barrier dysfunction and lethal colitis.…”

Section: Nutrient-associated Molecular Mechanismsmentioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

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Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan and delaying ageing in various species such as yeast, drosophila, rodent, primate and human. It emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse diseases. However, the nutritive advantages frequently diversify among individuals as well as organs and tissues, which brings challenges in this field. In this review, we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or clinical. We discuss the nutrient-mediated mechanisms including metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks. Comparably, we describe diet-responsive effectors by which dietary interventions influence the endocrinic, immunological, microbial and neural states responsible for improving health and preventing multiple diseases in humans. Furthermore, we expatiate diverse patterns of dietotheroapies, including different fasting, calorie-restricted diet, ketogenic diet, high-fibre diet, plants-based diet, protein restriction diet or diet with specific reduction in amino acids or microelements, potentially affecting the health and morbid states. Altogether, we emphasize the profound nutritional therapy, and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.

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“…Lancaster and colleagues found a similar result in a small crossover experiment with 18 participants using different fiber compositions. The researchers discovered that responses to different fiber types were not consistent across the participants, inferring that each person’s microbiome may influence their responses [ 100 ].…”

Section: Mechanism Of Dietary Fiber Action: How Does Dietary Fiber In...mentioning

confidence: 99%

Health Benefits of Dietary Fiber for the Management of Inflammatory Bowel Disease

2022

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Crohn’s disease (CD) and ulcerative colitis (UC), two components of inflammatory bowel disease (IBD), are painful conditions that affect children and adults. Despite substantial research, there is no permanent cure for IBD, and patients face an increased risk of colon cancer. Dietary fiber’s health advantages have been thoroughly investigated, and it is recommended for its enormous health benefits. This review article discusses the importance of appropriate fiber intake in managing IBD, emphasizing how optimal fiber consumption can significantly help IBD patients.

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Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans

Cited by 68 publications

References 90 publications

Role of dietary fiber in promoting immune health—An EAACI position paper

Role of dietary fiber in promoting immune health—An EAACI position paper

Dietary regulation in health and disease

Health Benefits of Dietary Fiber for the Management of Inflammatory Bowel Disease

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