Global distribution and potential risks of artificial sweeteners (ASs) with widespread contaminant in the environment: The latest advancements and future development

Wang, Xinglei; Liang, Xujun; Guo, Xuetao

doi:10.1016/j.trac.2023.116915

Cited by 5 publications

(3 citation statements)

References 83 publications

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“…Also, the migratory capacity is essential for avoiding predation and minimising UV exposure, locating feeding resources and moving away from unfavourable environments. Therefore, considering the key role of cladocerans in aquatic ecosystems and the wide distribution of artificial sweeteners (Wang et al, 2023), severe ecological consequences might occur if the behavioural impairments observed in the acute test are also present in wild populations under chronic exposure.…”

Section: Inhibition Of Swimming and Feedingmentioning

confidence: 99%

“…Artificial non-nutritive sweeteners (AS) are widely used in food and beverages for human consumption, animal feed, and pharmaceutical and personal care products to replace sucrose and decrease caloric uptake (Hough, 1993). ASs can be divided into two categories: the first generation, which mainly includes saccharin, cyclamate, and aspartame; and the second generation, which includes acesulfame, sucralose, neotame and neohesperidin dihydrochalcone (Wang et al, 2023). The survey from Euromonitor International (https://www.euromonitor.com/sugar-and-sweeteners; 2017) showed that aspartame was the most used AS (18.5 thousand metric tons), followed by saccharin (9.7 thousand metric tons), acesulfame (6.8 thousand metric tons), and sucralose (3.3 thousand metric tons).…”

Section: Introductionmentioning

confidence: 99%

“…Due to their relatively high stability and persistence in nature, the release of these compounds in the environment is also increasing. As a result, ASs are now considered emerging contaminants (Praveena et al, 2019;Wang et al, 2023), even though from the human health aspect, ASs have been regarded as safe additives to foodstuff (Kroger et al, 2006) and pharmaceuticals (Haroun and Haider, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Cardiotoxic and neurobehavioral effects of sucralose and acesulfame in Daphnia magna: toward understanding ecological impacts of artificial sweeteners

Wiklund

Guo

Gorokhova

2023

Preprint

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Artificial sweeteners are broadly used as safe food additives and in pharmaceutical formulations. As these compounds are relatively stable and poorly removed by water treatment facilities, their environmental concentrations increase. Therefore, concerns about their potential risks to non-targeted aquatic biota have been raised. Although no lethal effects are usually observed in standard toxicity testing, recent effect studies suggest a possible neurotoxic mode of action.We tested the effects of commonly used sugar substitutes (sucralose and acesulfame, up to 1 mg/L) in a nontarget species Daphnia magna, by assessing biochemical (acetylcholinesterase activity, AChE), physiological (heart rate, HR) and behavioural (time spent on swimming and feeding) endpoints. We found a dose-dependent increase in AChE activity and inhibitory effects on HR and behavioural endpoints, with lower EC 50 values observed for acesulfame than sucralose, although all these values were within the reported AS levels in the wastewater. Moreover, a biphasic response was observed for acesulfame-exposed daphnids, with AChE inhibition at the lower concentrations (< 1 μg/L ) and stimulatory effects at the higher concentrations. Thus, the response propagated across the biological organization levels, with swimming inhibition associated with AChE stimulation. Whereas HR and swimming were positively related across the ASs and all concentrations tested, the relationship between AChE and HR was substance-specific, suggesting possible differences in the mode of action. The observed LOEC values for acesulfame were as low as 0.1 μg/L , these results suggest that artificial sweeteners may exert adverse effects on nontarget biota at environmentally relevant concentrations, which calls for a critical evaluation of current thresholds used in their risk assessment.

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Section: Inhibition Of Swimming and Feedingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%