Abstract-Captain Charles Moore introduced the world to the "GreatPacific Garbage Patch" in the mid-1990s, and images of plastic debris in the oceans began to sweep the media. Since then, there has been increasing interest from scientists, the public, and policy makers regarding plastic debris in the environment. Today, there remains no doubt that plastic debris contaminates aquatic (marine and freshwater) habitats and animals globally. The growing scientific evidence demonstrates widespread contamination from plastic debris, and researchers are beginning to understand the sources, fate, and effects of the material. As new scientific understanding breeds new questions, scientists are working to fill data gaps regarding the fate and effects of plastic debris and the mechanisms that drive these processes. In parallel, policy makers are working to mitigate this contamination. The authors focus on what is known about plastic debris that is relevant to policy by reviewing some of the weight of evidence regarding contamination, fate, and effects of the material. Moreover, they highlight some examples of how science has already been used to inform policy change and mitigation and discuss opportunities for future linkages between science and policy to continue the relationship and contribute to effective solutions for plastic debris. Environ Toxicol Chem 2016;35:1617-1626 Captain Charles Moore is credited with discovering an accumulation of plastic debris floating in the middle of the Pacific Ocean in the mid-1990s and introducing this newfound issue to the world as the "North Pacific Garbage Patch" [1]. Since his discovery, Captain Moore's work likely served to intensify existing concern about the issue of plastics contamination and increased interest from the public, the scientific community, and policy makers. Increased public interest is evidenced by the increase in beach cleanups, environmental activist groups, and media attention regarding plastic debris. Increased scientific interest is evidenced by the large increase in scientific literature on the topic since the turn of the century [2,3]. For example, new literature now reports "garbage patches" in every major open ocean [4] and the presence of our plastic waste of all sizes in almost every major nook and cranny of marine and freshwater environments [4][5][6][7][8]. Increased interest from policy makers is evidenced by the formation of focus groups, which have sprung up in many agencies. For example, programs and working groups that focus on plastic debris have been created at the National Oceanic and Atmospheric Administration (NOAA) and the US Environmental Protection Agency (USEPA) in the United States, the Ministry of the Environment in Canada, The European Commission, the Northwest Pacific Action Plan in Asia, the Department of Environmental Affairs in South Africa, and globally at the United Nations Environment Programme (UNEP). Several of these groups aim to bring together the existing information to assemble a formal risk assessment, a common part of te...