2006
DOI: 10.1093/jn/136.11.2748
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Global DNA and p53 Region-Specific Hypomethylation in Human Colonic Cells Is Induced by Folate Depletion and Reversed by Folate Supplementation

Abstract: There is increasing evidence to suggest that reduced folate status may be a causative factor in carcinogenesis, particularly colorectal carcinogenesis. Folate is essential for the synthesis of S-adenosylmethionine, the methyl donor required for all methylation reactions in the cell, including the methylation of DNA. Global DNA hypomethylation appears to be an early, and consistent, molecular event in carcinogenesis. We have examined the effects of folate depletion on human-derived cultured colon carcinoma cell… Show more

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Cited by 105 publications
(63 citation statements)
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“…Tests for the presence of high-risk HPV (HR-HPV) were carried out by the Department of Microbiology, Tata Memorial Hospital, Mumbai, India, using the Digene Hybrid Capture II Assay (HC-2). Thirteen HR-HPV types (16,18,31,33,35,39,45,51,52,56,58,59, and 68) can be detected, although not distinguished, by this test (30).…”
Section: Methodsmentioning
confidence: 89%
See 1 more Smart Citation
“…Tests for the presence of high-risk HPV (HR-HPV) were carried out by the Department of Microbiology, Tata Memorial Hospital, Mumbai, India, using the Digene Hybrid Capture II Assay (HC-2). Thirteen HR-HPV types (16,18,31,33,35,39,45,51,52,56,58,59, and 68) can be detected, although not distinguished, by this test (30).…”
Section: Methodsmentioning
confidence: 89%
“…There was no simple relationship among folate status, DNA hypomethylation, and tumor suppressor gene hypermethylation. A relationship between lower folate status and global methylation has been described in colon systems, with a high degree of consistency (52). Furthermore, global hypomethylation can be lowered by folic acid supplementation (53), supporting a causal link.…”
Section: Discussionmentioning
confidence: 96%
“…Some reports have already described that a folate supplementation has the capacity to inhibit DNA hypomethylation because folate is the main micronutrients required to maintain an adequate cellular pool of the methyl donor S-adenosylmethionine, which is the universal methyl group donor required for DNA methylation (24). Thus, we decided to investigate the effect of folate supplementation on the DNA methylation status of glioma cells.…”
Section: Resultsmentioning
confidence: 99%
“…There are findings indicating that dietary Se influence epigenetic mechanisms involved in cancer and that nutrient interactions are important in cancer susceptibility (50). Methylation in the promoter region of the tumor suppressor p53 gene is sensitive to both folate (265) and Se (51), and this may be important in the early stages of cancer development. HDAC activity in B cell lymphoma cell lines has…”
Section: Epigenetic Poising In Naive T Helper Cells Does Se Intake Amentioning
confidence: 99%