Global DNA methylation and miR-126-3p expression in Mexican women with gestational diabetes mellitus: a pilot study

Lizárraga, Dennise; García-Gasca, Teresa; Lund, Gertrud; Ávalos-Soriano, Anaguiven; García-Gasca, Alejandra

doi:10.1007/s11033-023-09005-z

Cited by 2 publications

(1 citation statement)

References 20 publications

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“… 26 A study conducted in Tehran, Iran, revealed a significant correlation between PM 2.5 exposure in the first trimester and placental methylation, 27 and placental DNA methylation has been shown to be associated with GDM. 28 , 29 In addition, animal studies have shown that exposure to PM 2.5 can exacerbate oxidative stress, insulin resistance, inflammation and obesity. 30 , 31 During the prepregnancy period, women often experience weight gain due to an excessive focus on nutrient intake.…”

Section: Discussionmentioning

confidence: 99%

Effect of fine particulate matter exposure on gestational diabetes mellitus risk: a retrospective cohort study

Wan,

Zhang,

Zhuang

et al. 2024

European Journal of Public Health

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Background The literature on the association between fine particulate matter (PM2.5) exposure and gestational diabetes mellitus (GDM) risk has focused mainly on exposure during the first and second trimesters, and the research results are inconsistent. Therefore, this study aimed to investigate the associations between PM2.5 exposure during preconception, the first trimester and second trimester and GDM risk in pregnant women in Guangzhou. Methods A retrospective cohort study of 26 354 pregnant women was conducted, estimating PM2.5, particulate matter with a diameter >10 µm (PM10), sulphur dioxide (SO2), carbon monoxide (CO) and ozone (O3) exposure during preconception and the first and second trimesters. Analyses were performed using Cox proportional hazards models and nonlinear distributed lag models. Results The study found that exposure to PM2.5 or a combination of two pollutants (PM2.5+PM10, PM2.5+SO2, PM2.5+CO and PM2.5+O3) was found to be significantly associated with GDM risk (P < 0.05). In the second trimester, with significant interactions found for occupation and anaemia between PM2.5 and GDM. When the PM2.5 concentrations were ≥19.56, ≥25.69 and ≥23.87 μg/m3 during preconception and the first and second trimesters, respectively, the hazard ratio for GDM started to increase. The critical window for PM2.5 exposure was identified to be from 9 to 11 weeks before conception. Conclusions Our study results suggest that PM2.5 exposure during preconception and the first and second trimesters increases the risk of GDM, with the preconception period appearing to be the critical window for PM2.5 exposure.

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Section: Discussionmentioning

confidence: 99%

Effect of fine particulate matter exposure on gestational diabetes mellitus risk: a retrospective cohort study

Wan,

Zhang,

Zhuang

et al. 2024

European Journal of Public Health

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Research Progress of Risk Factors Associated with Gestational Diabetes Mellitus

Lin,

He,

2025

EMIDDT

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Gestational Diabetes Mellitus (GDM) is a common endocrine condition associated with adverse pregnancy outcomes. In recent years, a growing number of risk factors associated with gestational diabetes mellitus have been defined. GDM poses a serious threat to maternal health. The etiology is complex and multifactorial and can be divided into inherent and modifiable factors. The inherent factors have been described in other literature, while the modifiable factors are mainly the risk of lifestyle habits. In this study, we performed a narrative review of the progress of risk factors associated with gestational diabetes mellitus.

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Global DNA methylation and miR-126-3p expression in Mexican women with gestational diabetes mellitus: a pilot study

Cited by 2 publications

References 20 publications

Effect of fine particulate matter exposure on gestational diabetes mellitus risk: a retrospective cohort study

Effect of fine particulate matter exposure on gestational diabetes mellitus risk: a retrospective cohort study

Research Progress of Risk Factors Associated with Gestational Diabetes Mellitus

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