Global epidemiology and holistic prevention of pancreatitis

Petrov, Maxim S.; Yadav, Dhiraj

doi:10.1038/s41575-018-0087-5

Cited by 589 publications

(500 citation statements)

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“…Recent consensus guidelines indicate that the correct categorization of patients based on etiology is important, as the incidence of pancreatic cancer varies between different etiologies . Data on the incidence and prevalence of chronic pancreatitis are hampered by diagnostic difficulties, but current estimates suggest that a yearly incidence of 10 cases per 100,000 population, with the age‐adjusted and sex‐adjusted prevalence in the United States of 42 cases per 100,000 population …”

Section: Introductionmentioning

confidence: 99%

Chronic Pancreatitis and Nutrition Therapy

O’Brien

Omer

2019

Nut in Clin Prac

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Chronic pancreatitis is a complex and irreversible disease of the pancreas and is associated with significant morbidity and mortality. Nutrition deficiencies in chronic pancreatitis are common and can be atypical in nature. As such, the management of these deficiencies can be individualized for patients. The aim of this review is to discuss the components of nutrition deficiencies in chronic pancreatitis, their management, and the current areas of research that are being explored. The clinical guidelines of major national and international societies were analyzed for recommendations on the nutrition management of chronic pancreatitis. The etiology of nutrition deficiencies in chronic pancreatitis is multifactorial and includes aspects of exocrine and/or endocrine dysfunction, significant abdominal pain, often persistent alcohol consumption, and increased metabolic activity. A large number of patients with nutrition deficiencies are underrecognized and undertreated. Although the majority of these patients can be managed by oral and pancreatic enzyme supplementation, some patients may require enteral tube feeding and, in rare cases, parenteral feeding. Current areas of research include the accurate identification of patients at risk for nutrition deficiencies, optimization of feeding regimens, and research into islet cell autotransplantation. (Nutr Clin Pract. 2019;34(suppl 1):S13-S26)

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Section: Introductionmentioning

confidence: 99%

Chronic Pancreatitis and Nutrition Therapy

O’Brien

Omer

2019

Nut in Clin Prac

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“…Acute pancreatitis (AP) is an in ammatory disease of the pancreas that causes considerable morbidity and mortality [1]. The global incidence of AP is approximately 30 cases per 100,000 persons, and has been increasing universally [2]. In addition, about 20% of AP cases evolve into severe acute pancreatitis (SAP), with a mortality rate of 15% [3].…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA H19 regulates the therapeutic efficacy of mesenchymal stem cells in rats with severe acute pancreatitis by sponging miR-138-5p and miR-141-3p

Song

Zhou

Song

et al. 2020

Preprint

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Background: Patients with severe acute pancreatitis (SAP), which is characterized by high morbidity and mortality, account for an increasing medical burden worldwide. We previously found that mesenchymal stem cells (MSCs) could attenuate SAP and that expression of long noncoding RNA H19 (LncRNA H19) was upregulated in rats receiving MSCs. In the present study, we investigated the mechanisms of LncRNA H19 regulating the therapeutic efficacy of MSCs in the alleviation of SAP.Methods: MSCs transfected with LncRNA H19 overexpression and knock down plasmids were intravenously injected into rats 12 h after sodium taurocholate (NaT) administration to induce SAP.Results: Overexpressing LncRNA H19 in MSCs significantly enhanced the anti-inflammatory capacity of the MSCs, inhibited autophagy via promotion of focal adhesion kinase (FAK)-associated pathways, and facilitated cell proliferation by increasing the level of β-catenin in rats with SAP. LncRNA H19 functioned as a competing endogenous RNA by sponging miR-138-5p and miR-141-3p. Knocking down miR-138-5p in MSCs increased the expression of protein tyrosine kinase 2 (PTK2, encoding FAK) to suppress autophagy, while downregulating miR-141-3p enhanced the level of β-catenin to promote cell proliferation.Conclusions: In conclusion, LncRNA H19 effectively increased the therapeutic efficacy of MSCs in rats with SAP via the miR-138-5p/PTK2/FAK and miR-141-3p/β-catenin pathways.

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“…Sıklıkla karşılaşılan hafif ödematöz formdan ağır nekrotizan forma kadar değişik şiddette seyredebilen klinik bir durumdur (2,3). İnsan vücudunda, lokal, bölgesel ve sistemik yansımalara, komplikasyonlara yol açan, mortalite ve morbidite oranları ciddiye alınması gereken bir hastalıktır (4). Çeşitli yayınlarda akut pankreatit insidansı yılda 1-5/10000 olarak bildirilmekle birlikte, hafif olguların bir kısmının sağlık merkezlerine müracaat etmeden hastalığı geçirdiği göz önüne alınırsa gerçek akut pankreatit sıklığının daha fazla olduğu söylenebilir (4,5).…”

Section: Introductionunclassified

“…İnsan vücudunda, lokal, bölgesel ve sistemik yansımalara, komplikasyonlara yol açan, mortalite ve morbidite oranları ciddiye alınması gereken bir hastalıktır (4). Çeşitli yayınlarda akut pankreatit insidansı yılda 1-5/10000 olarak bildirilmekle birlikte, hafif olguların bir kısmının sağlık merkezlerine müracaat etmeden hastalığı geçirdiği göz önüne alınırsa gerçek akut pankreatit sıklığının daha fazla olduğu söylenebilir (4,5). Kadın ve erkekleri yaklaşık olarak eşit oranda etkileyen bu hastalık; her yaş grubunda ama en sık 30-60 yaş aralığında rastlanmaktadır (5).…”

Section: Introductionunclassified

Evaluation of relationship between mean platelet volume and red cell distribution width levels in cases with acute pancreatitis and its severity

Pençe¹,

Tanoğlu²,

Düzenli³

et al. 2019

Kocaeli Med J

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ÖZ GİRİŞ ve AMAÇ: Akut pankreatit gastrointestinal sistemin önde gelen bir inflamatuar klinik tablosudur. Bu çalışmanın amacı, akut pankreatit ve hastalık şiddeti ile ortalama trombosit hacmi (OTH), eritrosit dağılım genişliği (EDG) ve diğer inflamatuar belirteçler arasındaki ilişkiyi belirlemekti. YÖNTEM ve GEREÇLER: 94 akut pankreatitli hasta (erkek/bayan: 55/39) ve 70 sağlıklı kontrol (erkek/bayan: 42/28) çalışmaya dahil edildi. OTH, EDG ve diğer inflamatuar belirteçler tüm çalışmaya katılanlarda ölçüldü. Akut pankreatitli olgularda hastalık ciddiyetini belirlemek için Ranson skoru kullanıldı.BULGULAR: Akut pankreatitli olgularda, sağlıklı kontrollere gore OTH seviyeleri istatistiki olarak anlamlı düzeyde baskılanmıştı (7,9±1,1 fL ile 8, 4±0,9 fL; p=0,003), EDG seviyeleri ise sağlıklı kontrollere göre anlamlı düzeyde yükselmişti (%12,8±1,5 ile %11,7±0,7; p<0,01). Ranson skoru ≥3 olanlarda, olmayanlara gore OTH hacmi değerleri daha belirgin baskılanmıştı (p<0,001). TARTIŞMA ve SONUÇ:Akut pankreatit ve onun şiddetinin belirlemede tek ve ideal bir metod olmamasına rağmen, OTH hastaneye başvuru esnasında akut pankreatit ve onun ciddiyetinin belirlemede ucuz ve kolay elde edilebilir bir marker olarak kullanılabilir.Anahtar Kelimeler: Akut pankreatit, inflamasyon, ortalama trombosit hacmi, eritrosit dağılım genişliği ABSTRACT INTRODUCTION: Acute pancreatitis is one of the major inflammatory clinical tables among gastrointestinal system diseases. The aim of this study was to determine the relationship between the mean platelet volume (MPV), red cell distribution width (RDW) and other inflammatory markers with acute pancreatitis and its severity. METHODS:A total of 94 acute pancreatitis patients (male/female: 55/39), and 70 healthy subjects (male/female: 42/28) were enrolled in this study. MPV, RDW and other inflammatory parameters were measured for all participants. Ranson Score was used as to predict the disease severity in cases with acute pancreatitis. RESULTS:A statistically significant decrease in MPV levels was observed in acute pancreatitis cases compared with healthy controls (7.9±1.1 fL and 8.4±0.9 fL; p=0.003). RDW levels were significantly increased compared to healthy controls (12.8%±1.5 and 11.7%±0.7; p<0.01). MPV levels were more significantly decreases patients with Ranson score ≥3, compared with Ranson score <3 (p<0.001). DISCUSSION AND CONCLUSION:Although there is no unique, favorable method to assess acute pancreatitis and its severity, MPV level at hospital admission may be used as an easy and cheap marker in earlier prediction of acute pancreatitis and its seriousness.

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Global epidemiology and holistic prevention of pancreatitis

Cited by 589 publications

References 84 publications

Chronic Pancreatitis and Nutrition Therapy

Chronic Pancreatitis and Nutrition Therapy

Long noncoding RNA H19 regulates the therapeutic efficacy of mesenchymal stem cells in rats with severe acute pancreatitis by sponging miR-138-5p and miR-141-3p

Evaluation of relationship between mean platelet volume and red cell distribution width levels in cases with acute pancreatitis and its severity

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