Global epidemiology of mental disorder in atrial fibrillation between 1998-2021: A systematic review and meta-analysis

Abstract

BACKGROUND As the burden of mental disorders among patients with atrial fibrillation (AF) increases, researchers are beginning to pay close attention to the risk and prevalence of these comorbidities. Although studies have independently analyzed the risk of comorbidity with depression and anxiety in patients with AF, no study has systematically focused on the global epidemiology of these two mental disorders. AIM To explore the prevalence of depression and anxiety in patients with AF. METHODS Five databases were searched from their date of establishment until January 2023. Observational studies reporting the comorbidity of AF with depression and anxiety, were included in this study. Basic information, such as the first author/ publication year, study year, study type, and prevalence of depression and anxiety, were extracted. STATA SE 15.1 was used to analyze the data. Subgroup, meta-regression, and sensitivity analyses were performed to estimate study heterogeneity. RESULTS After a thorough search, 26 studies were identified and included in this meta-analysis. The prevalence rates of depression and anxiety in adults with AF were 24.3% and 14.5%, respectively. Among adult males with AF, the prevalence was 11.7% and 8.7%, respectively, whereas in females it was 19.8% and 10.1%, respectively. In older adults with AF, the prevalence rates of depression and anxiety were 40.3% and 33.6%, respectively. The highest regional prevalence of depression and anxiety was observed in European (30.2%) and North American (19.8%) patients with AF. CONCLUSION In this study, we found that the prevalence of depression and anxiety among patients with AF varies with sex, region, and evaluation scales, suggesting the need for psychological interventions for patients with AF in clinical practice.

Association between depression and infertility risk among American women aged 18–45 years: the mediating effect of the NHHR

“…Mental disorders have a significant impact on the global burden of disease. According to a report released by the World Health Organization (WHO) in 2019, approximately 970 million people around the world are afflicted by mental disorders, with depression recognized as one of the prevalent manifestations [ 6 ]. Additionally, insights from the 2019 Global Burden of Disease Study highlighted that depression ranks among the foremost causes of disability, affecting around 280 million individuals annually and resulting in disability for more than 47 million individuals [ 7 , 8 ].…”