Global epidemiology of type 1 diabetes in young adults and adults: a systematic review

Díaz-Valencia, Paula Andrea; Bougnères, Pierre; Valleron, Alain‐Jacques

doi:10.1186/s12889-015-1591-y

Cited by 233 publications

(191 citation statements)

References 83 publications

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“…The diagnosis of T1D was precise and clinically verified, which facilitated the inclusion of patients diagnosed after 30 years of age. Almost 1 in 3 patients in our T1D population was diagnosed after 30 years of age, which is in accordance with the distribution found in other studies 12,52 ; information on this group of patients is particularly scarce in the literature.…”

Section: Discussionsupporting

confidence: 91%

Prediction of First Cardiovascular Disease Event in Type 1 Diabetes Mellitus

et al. 2016

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Background— Patients with type 1 diabetes mellitus are at increased risk of developing cardiovascular disease (CVD), but they are currently undertreated. There are no risk scores used on a regular basis in clinical practice for assessing the risk of CVD in type 1 diabetes mellitus. Methods and Results— From 4306 clinically diagnosed adult patients with type 1 diabetes mellitus, we developed a prediction model for estimating the risk of first fatal or nonfatal CVD event (ischemic heart disease, ischemic stroke, heart failure, and peripheral artery disease). Detailed clinical data including lifestyle factors were linked to event data from validated national registers. The risk prediction model was developed by using a 2-stage approach. First, a nonparametric, data-driven approach was used to identify potentially informative risk factors and interactions (random forest and survival tree analysis). Second, based on results from the first step, Poisson regression analysis was used to derive the final model. The final CVD prediction model was externally validated in a different population of 2119 patients with type 1 diabetes mellitus. During a median follow-up of 6.8 years (interquartile range, 2.9–10.9) a total of 793 (18.4%) patients developed CVD. The final prediction model included age, sex, diabetes duration, systolic blood pressure, low-density lipoprotein cholesterol, hemoglobin A 1c , albuminuria, glomerular filtration rate, smoking, and exercise. Discrimination was excellent for a 5-year CVD event with a C-statistic of 0.826 (95% confidence interval, 0.807–0.845) in the derivation data and a C-statistic of 0.803 (95% confidence interval, 0.767–0.839) in the validation data. The Hosmer-Lemeshow test showed good calibration ( P >0.05) in both cohorts. Conclusions— This high-performing CVD risk model allows for the implementation of decision rules in a clinical setting.

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Section: Discussionsupporting

confidence: 91%

Prediction of First Cardiovascular Disease Event in Type 1 Diabetes Mellitus

et al. 2016

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“…Fifth, we could not differentiate between type 1 and type 2 diabetes. The risk of severe hypoglycaemia and hypoglycaemia-related mortality is different between the two phenotypes and their prevalence varies across countries [47]. While in type 1 diabetes severe hypoglycaemia is more likely to be the underlying cause of death, in type 2 diabetes a higher prevalence of cardiovascular disease could contribute to an increased risk of fatal hypoglycaemia.…”

Section: Discussionmentioning

confidence: 99%

Global burden of hypoglycaemia-related mortality in 109 countries, from 2000 to 2014: an analysis of death certificates

et al. 2018

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Aims/hypothesis In the context of increasing prevalence of diabetes in elderly people with multimorbidity, intensive glucose control may increase the risk of severe hypoglycaemia, potentially leading to death. While rising trends of severe hypoglycaemia rates have been reported in some European, North American and Asian countries, the global burden of hypoglycaemia-related mortality is unknown. We aimed to investigate global differences and trends of hypoglycaemia-related mortality. Methods We used the WHO mortality database to extract information on death certificates reporting hypoglycaemia or diabetes as the underlying cause of death, and the United Nations demographic database to obtain data on mid-year population estimates from 2000 to 2014. We calculated crude and age-standardised proportions (defined as number of hypoglycaemia-related deaths divided by total number of deaths from diabetes [i.e. the sum of hypoglycaemia-and diabetes-related deaths]) and rates (hypoglycaemia-related deaths divided by mid-year population) of hypoglycaemia-related mortality and compared estimates across countries and over time.Results Data for proportions were extracted from 109 countries (31 had data from all years analysed [2000][2001][2002][2003][2004][2005][2006][2007][2008][2009][2010][2011][2012][2013][2014] available). Combining all countries, the age-standardised proportion of hypoglycaemia-related deaths was 4.49 (95% CI 4.44, 4.55) per 1000 total diabetes deaths. Compared with the overall mean, most Central American, South American and (mainly) Caribbean countries reported higher proportions (five more age-standardised hypoglycaemia-related deaths per 1000 total diabetes deaths in Chile, six in Uruguay, 11 in Belize and 22 in Aruba), as well as Japan (11 more age-standardised hypoglycaemia-related deaths per 1000 total diabetes deaths). In comparison, lower proportions were noted in most European countries, the USA, Canada, New Zealand and Australia. For countries with data available for all years analysed, trend analysis showed a 60% increase in hypoglycaemia-related deaths until 2010 and stable trends onwards. Rising trends were most evident for Argentina, Brazil, Chile, the USA and Japan. Data for rates were available for 105 countries (30 had data for all years analysed [2000][2001][2002][2003][2004][2005][2006][2007][2008][2009][2010][2011][2012][2013][2014] available). Combining all countries, the age-standardised hypoglycaemia-related death rate was 0.79 (95% CI 0.77, 0.80) per 1 million person-years. Most Central American, South American and Caribbean countries similarly reported higher rates of hypoglycaemia-related death, whilst virtually all European countries, the USA, Canada, Japan, New Zealand and Australia reported lower rates compared with the overall mean. Age-standardised rates were very low for most countries (lower than five per 1 million person-years in 89.5% of countries), resulting in small absolute differences among countries. As noted with the proportions analysis, trend analysis sho...

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“…Incidence of type 1 diabetes increases continuously worldwide [1][2][3] of progression to end-stage renal disease (ESRD) and one of the major predictors of premature death [4,5] the association between rapid GFR decline and renal hyperfiltration is not well described in Type 1 diabetes. We hypothesized that renal hyperfiltration (estimated glomerular filtration rate, eGFR \u2265 120 mL/min/1.73 m(2).…”

Section: Introductionmentioning

confidence: 99%

Związek polimorfizmu rs 3807337 genu CALD1 z nefropatią cukrzycową w przebiegu cukrzycy typu 1 — wstępne wyniki badania rodzin

Śnit

Nabrdalik

Długaszek

et al. 2017

Endokrynologia Polska

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Introduction: The worldwide growing burden of diabetes and end-stage renal disease due to diabetic nephropathy has become the reason for research looking for a single marker of chronic kidney disease development and progression that can be found in the early stages of the disease, when preventive action delaying the destructive process could be performed. The aim of the study was to investigate the influence of rs3807337 polymorphism of the caldesmon 1 (CALD1) gene located on the long arm of chromosome 7 encoding for protein that is connected with physiological kidney function on development of diabetic nephropathy. Material and methods: There was an association study of rs3807337 polymorphism of the CALD1 gene in parent-offspring trios by PCR-RFLP method. Ninety-nine subjects: 33 patients with diabetic nephropathy due to type 1 diabetes and 66 of their biological parents, were examined. The mode of alleles transmission from heterozygous parents to affected offspring was determined using the transmission disequilibrium test. Results: The allele G of rs3807337 polymorphism of the CALD1 gene was transmitted to affected offspring significantly more often than expected for no association. Conclusions:The obtained results suggest that the genetic variability of the CALD1 gene may influence the development of diabetic nephropathy in type 1 diabetes, but further studies involving larger studied groups of patients are needed. (Endokrynol Pol 2017; 68 (1): 13-17)

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Global epidemiology of type 1 diabetes in young adults and adults: a systematic review

Cited by 233 publications

References 83 publications

Prediction of First Cardiovascular Disease Event in Type 1 Diabetes Mellitus

Prediction of First Cardiovascular Disease Event in Type 1 Diabetes Mellitus

Global burden of hypoglycaemia-related mortality in 109 countries, from 2000 to 2014: an analysis of death certificates

Związek polimorfizmu rs 3807337 genu CALD1 z nefropatią cukrzycową w przebiegu cukrzycy typu 1 — wstępne wyniki badania rodzin

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