Global Eradication of Measles: An Epidemiologic and Economic Evaluation

Levin, Ann; Burgess, Colleen; Garrison, Louis P.; Bauch, Chris T.; Babigumira, Joseph B.; Simons, Emily; Dabbagh, Alya

doi:10.1093/infdis/jir096

Cited by 75 publications

(77 citation statements)

References 4 publications

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“…5,12,18 In this study, we found that from 2011-2015 a unit change of doses of measles vaccines administered into the population reduced the risk of measles by 30%. A yearly analysis however indicated excess risk due to vaccine administration usually when only outbreak response were conducted in most part of the year as reflected in the increasing burden of the disease among vaccinated population in 2011, 2013 and 2014.…”

Section: Discussionmentioning

confidence: 58%

“…In recent times, similar factors have accounted for the occurrence of outbreaks in both developing and underdeveloped countries. 10,11,[16][17][18][19] Comparing the risk of measles among vaccinated population over time was limited by possible recall bias since vaccination status of cases was not evidenced by card and detailed history of vaccine handling. Therefore, the extent of variation of trends that could be attributed to vaccine failure may be deficient but possibly cannot be discounted considering the weak health system.…”

Section: Discussionmentioning

confidence: 99%

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Targeted Measles Outbreak Response Vaccination In The Context of Measles Control and Elimination: Experiences From South Sudan

Boateng¹,

Usman²,

Laku³

et al. 2016

Epidemiol Open J

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Introduction: Measles elimination interventions in South Sudan have relied on mass campaigns due to reoccurring humanitarian crisis over decades. This paper examines the effects of targeted measles vaccinations on efforts at eliminating measles in the country. Methods: Time trend and an analytical cross-sectional design were applied on South Sudan Measles case-based surveillance dataset 2011-2015. Logistic regression of IgM positive cases against vaccination status and adjusted for age and unknown vaccination status were used to determine the likelihood of reduced risk of measles at 95% CI. Results: Routine immunization, follow-up and outbreak response coverage for measles vaccination over the period were sub-optimal. Even though the proportion of confirmed measles cases among vaccinated population was irregular ranging 14.2% to 61.9% within the period reviewed, measles vaccination generally reduced the risk of the disease in the population by 30% (odds 0.7, 95% CI 0.4, 1.0) from 2011-2015. A trend analysis showed that the likelihood of reduction of measles burden varied per year, but a higher reduction of risk was observed in 2015 (odds 0.05 (95% CI <0.01, 0.35) preceded by follow-up campaigns. Adjusting for age and unknown vaccination status, there were no statistically significant difference for the trends of odds, however the significant decrease in odds in 2015 (OR 0.01 (95% CI [0.01, 0.35]) R 2 0.45) is due to a unit change in age. Conclusions: Targeted measles outbreak vaccinations generally reduce the burden of measles however the extent of reduction is more reflected in a year following a mass measles campaign as compared to outbreak response vaccination. Thus measles follow-up campaigns are necessary for sustained measles control and elimination.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Targeted Measles Outbreak Response Vaccination In The Context of Measles Control and Elimination: Experiences From South Sudan

Boateng¹,

Usman²,

Laku³

et al. 2016

Epidemiol Open J

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“…Students have measles more often that other groups, which proves the need of their vaccination as a matter of priority. [1,6,12,13] The objective of our research was the assessment of epidemiological situation on measles in one of regions of the Republic of Kazakhstan.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Omarova

2017

AJP

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“…As coverage declines large-scale outbreaks are inevitable. Economic modeling has demonstrated that a coordinated campaign achieving global interruption of measles virus circulation by 2020 would result in a massive return on investment freeing up considerable finances currently required for treating hospitalized cases and responding to outbreaks [24]. However any decrease in the level of investment will rapidly result in a rebound of cases and deaths with a catastrophic loss of recent gains [11].…”

Section: The Duty Of Care and Rule To Rescuementioning

confidence: 99%