Global estimates of the prevalence of hyperglycaemia in pregnancy

Guariguata, Leonor; Linnenkamp, Ute; Beagley, Jessica; Whiting, David; Cho, N.H.

doi:10.1016/j.diabres.2013.11.003

Cited by 547 publications

(409 citation statements)

References 31 publications

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“…The long term implications of a pregnancy affected by GDM include a substantially increased risk of the mother developing type 2 diabetes post-natally, as well as the offspring having an increased susceptibility to obesity and related metabolic complications in adulthood [1]. Recent reports show that the prevalence of GDM is as high as 23% in some populations [2] and is predicted to rise in parallel to the increasing rates of maternal obesity. To date, early pregnancy screening tools to identify women at-risk of developing either GDM in later pregnancy [3], or Type 2 diabetes post-natally [4] are of limited efficacy.…”

Section: Introductionmentioning

confidence: 99%

Early pregnancy metabolite profiling discovers a potential biomarker for the subsequent development of gestational diabetes mellitus

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Early pregnancy metabolite profiling discovers a potential biomarker for the subsequent development of gestational diabetes mellitus

et al. 2014

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“…Hyperglycemia in pregnancy (HIP) represents an early, potentially sentinel part of the diabetes epidemic, with recent estimates suggesting that 21.4/127.1 million births each year across the world are affected by HIP and that .90% of cases occur in LMICs (43). Several international organizations have recognized the threat that HIP poses to otherwise improving maternal and neonatal outcomes.…”

Section: Actionmentioning

confidence: 99%

Discovery, Knowledge, and Action—Diabetes in Pregnancy Across the Translational Spectrum: The 2016 Norbert Freinkel Award Lecture

McIntyre

2018

Diabetes Care

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The Norbert Freinkel Award is given in memory of Norbert Freinkel, a dedicated and insightful investigator and gifted writer, to honor a researcher who has made outstanding contributions, including scientific publications and presentations, to the understanding and treatment of diabetes in pregnancy. H. David McIntyre, MD, FRACP, Director of Obstetric Medicine at Mater Health Services and Head of the Mater Clinical Unit at The University of Queensland in Brisbane, Australia, received the prestigious award at the American Diabetes Association's 76th Scientific Sessions, 10–14 June 2016, in New Orleans, LA. He presented the Norbert Freinkel Award Lecture, “Discovery, Knowledge, and Action—Diabetes in Pregnancy Across the Translational Spectrum,” on Saturday, 11 June 2016.

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“…Gestational diabetes mellitus (GDM), until recently defined as any degree of hyperglycaemia first detected in pregnancy [1], is a growing public health concern [2]. The prevalence of GDM shows an increasing trend in most racial/ethnic groups and parallels the global epidemic of obesity and type 2 diabetes [3].…”

Section: Gdm Gestational Diabetes Mellitusmentioning

confidence: 99%

Gestational diabetes: what’s up?

Berntorp

2016

Diabetologia

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GDM and maternal obesity are independently associated with adverse pregnancy outcomes, and children born to mothers with GDM and overweight/obesity are more likely to be macrosomic and large for their gestational age [9][10][11]. In addition to short-term complications, they also have an increased risk of long-term complications similar to those in their mothers [12,13]. Studies indicate that offspring exposed to maternal diabetes or GDM in utero are at a higher risk of developing childhood obesity and glucose intolerance in early adulthood than offspring not exposed to maternal diabetes [12,14]. Moreover, if the offspring is female, she is more likely to develop GDM herself and thereby create a vicious circle. Prevention of GDM and fetal over-nutrition in pregnancy could therefore be important strategies to interrupt this trans-generational cycle of obesity and diabetes (Fig. 1).To date, several studies have demonstrated the effectiveness of lifestyle interventions in the prevention of type 2 diabetes [15]. A beneficial effect on the risk of diabetes was also found in the Diabetes Prevention Program in women with a history of GDM, which was sustained during a 10-year follow-up period [16]. Since obesity is one of the most powerful modifiable risk factors for GDM in pregnant women [12,17], many intervention studies have focused on reducing weight or on reducing gestational weight gain in pregnancy, most often by changes in diet and physical activity. The effects of combined diet and exercise interventions during pregnancy were recently reviewed by Cochrane [18]. No clear evidence for the prevention of GDM was found. In contrast, a newly published meta-analysis concluded that moderate exercise programmes initiated early during pregnancy reduce the risk of GDM and excessive gestational weight gain [19]. Ideally, interventions aimed at improving metabolic conditions and placental function in obese women should take place before pregnancy, prior to conception [20]. Interestingly, Zhang et al recently reported that adherence to a healthy lifestyle in the Diabetologia

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Global estimates of the prevalence of hyperglycaemia in pregnancy

Cited by 547 publications

References 31 publications

Early pregnancy metabolite profiling discovers a potential biomarker for the subsequent development of gestational diabetes mellitus

Early pregnancy metabolite profiling discovers a potential biomarker for the subsequent development of gestational diabetes mellitus

Discovery, Knowledge, and Action—Diabetes in Pregnancy Across the Translational Spectrum: The 2016 Norbert Freinkel Award Lecture

Gestational diabetes: what’s up?

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