Key words Keller-Segel system, global and local existence, blow-up rate, weak L p − L q estimate MSC (2000) 35Q30We shall show an exact time interval for the existence of local strong solutions to the Keller-Segel system with the initial data u0 in L n 2is sufficiently small, then our solution exists globally in time. Our motivation to construct solutions in L n 2 w (R n ) stems from obtaining a self-similar solution which does not belong to any usual L p (R n ). Furthermore, the characterization of local existence of solutions gives us an explicit blow-up rate of u(t) L p (R n ) for n 2 < p ≤ ∞ as t → Tmax, where Tmax denotes the maximal existence time.Let us consider the Keller-Segel system of parabolic-elliptic type in R n for n ≥ 3;where u = u(x, t) and v = v(x, t) denote the unknown density of amoebae and the unknown concentration of the chemo-attractant, respectively, while u 0 = u 0 (x) is the given initial data, and γ is the given nonnegative constant. The purpose of this paper is to show the local and global existence of strong solutions to (KS) with the initial data u 0 in L n 2 w (R n ), where L p w (R n ) denotes the weak L p -space on R n . In the 2-dimensional ball B 2 , Nagai-SenbaYoshida [24] proved that if B2 u 0 (x) dx < 8π, then there exists a global solution {u, v} to (KS). The same result in the 2-dimensional whole plane R 2 had been obtained by . Later on, Nagai [25] showed that if u 0 satisfies R 2 u 0 (x) dx > 8π together with some additional assumption on R 2 |x| 2 u 0 (x) dx, then the solution {u, v} blows up within a finite time. For n ≥ 3, Corrias-Perthame-Zaag [6] constructed a global weak solution of (KS) provided that u 0 L n 2 (R n ) is sufficiently small. More precise investigation on global solutions including asymptotic behaviour as t → ∞ has been obtained by . Similar blow-up results for n ≥ 3 to the 2-dimensional case were also derived from [25], [6] under some hypothesis on R n u 0 (x) dx and R n |x| n u 0 (x) dx. In the case of n = 3, Herrero-Medina-Velázquez [10] constructed a selfsimilar solution blowing up in a finite time with an explicite rate. Recently, Senba [27] treated the Jäger-Luckhaus system in R n for n ≥ 3 and constructed a blow-up solution by means of the backward self-similar solution. More general result on blow-up solutions was given by Sugiyama [31]; there are a sequence u j 0 ∞ j=0 of initial data