Global field synchronization of 40 Hz auditory steady-state response: Does it change with attentional demands?

Abstract

Auditory steady-state responses (ASSRs) are increasingly used in research of neuropsychiatric disorders and for brain-computer interface applications. However, results on attentional modulation of ASSRs are inconclusive. The evaluation of large-scale effects of task-related modulation on ASSRs might give better estimation of the induced changes. The aim of the study was to test global field synchronization - a reference-independent evaluation of the amount of phase-locking among all active regions at a given frequency - during tasks differing in attentional demands to 40 Hz auditory stimulation. Twenty seven healthy young males participated in the EEG study with concurrent 40 Hz binaural click stimulation and three experimental tasks: 1) to count presented stimuli (focused attention); 2) to silently read a text (distraction); 3) to stay awake with closed eyes (resting). We showed that during auditory 40 Hz stimulation, the global field synchronization of the EEG increased as compared to the silent baseline period and the largest increase was observed when subjects counted stimuli or rested with closed eyes. Our results provide insights that depending on the method of assessment, the 40 Hz ASSR might be an indicator of both local and complex synchronization processes that are affected by the state (task performed or psychopathology) of the participants.